Selection at Work in Plasmodium Falciparum: Lessons From the Expanded Acyl CoA Synthetase Gene Family and in Vitro Artemisinin Resistance.

Autor: Demas, Allison Ross

Approximately one third of the world’s population is at risk of contracting malaria. The World Health Organization estimates there were over 200 million news cases of malaria in 2015, resulting in nearly 500,000 deaths from this preventable disease

Externí odkaz: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493610

Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility

Autor: Demas, Allison R., Sharma, Aabha I., Wong, Wesley, Early, Angela M., Redmond, Seth, Bopp, Selina, Neafsey, Daniel E., Volkman, Sarah K., Hartl, Daniel L., Wirth, Dyann F.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2018 Dec 01. 115(50), 12799-12804.

Externí odkaz: https://www.jstor.org/stable/26580162

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Lysophosphatidylcholine regulates sexual Stage differentiation in the human malaria parasite Plasmodium falciparum

Autor: Brancucci, Nicolas M.B., Gerdt, Joseph P., Wang, ChengQi, De Niz, Mariana, Philip, Nisha, Adapa, Swamy R., Zhang, Min, Hitz, Eva, Niederwieser, Igor, Boltryk, Sylwia D., Laffitte, Marie-Claude, Clark, Martha A., Grüring, Christof, Ravel, Deepali, Blancke Soares, Alexandra, Demas, Allison, Bopp, Selina, Rubio-Ruiz, Belén, Conejo-Garcia, Ana, Wirth, Dyann F., Gendaszewska-Darmach, Edyta, Duraisingh, Manoj T., Adams, John H., Voss, Till S., Waters, Andrew P., Jiang, Rays H.Y., Clardy, Jon, Marti, Matthias

Publikováno v: Brancucci, N M B, Gerdt, J P, Wang, C, De Niz, M, Philip, N, Adapa, S R, Zhang, M, Hitz, E, Niederwieser, I, Boltryk, S D, Laffitte, M-C, Clark, M A, Grüring, C, Ravel, D, Blancke Soares, A, Demas, A, Bopp, S, Rubio-Ruiz, B, Conejo-Garcia, A, Wirth, D F, Gendaszewska-Darmach, E, Duraisingh, M T, Adams, J H, Voss, T S, Waters, A P, Jiang, R H Y, Clardy, J & Marti, M 2017, ' Lysophosphatidylcholine regulates sexual stage differentiation in the human Malaria Parasite Plasmodium falciparum ', Cell, vol. 171, no. 7, pp. 1532-1544.e15 . https://doi.org/10.1016/j.cell.2017.10.020

Transmission represents a population bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes, ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7cac7f2fa13a36f4b41ffbe609244c3c
https://eprints.gla.ac.uk/149981/1/149981.pdf

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