Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Demarco Steven James"'
Autor:
Ravi S. Keshari, Narcis I. Popescu, Robert Silasi, Hala Chaaban, Demarco Steven James, Cristina Lupu, K. Mark Coggeshall, Maulin M. Patel, Florea Lupu, Tom Eirik Mollnes
Publikováno v:
E6390-E6399
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Source at https://doi.org/10.1073/pnas.1706818114. Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8a81b126207bdeca070e2a316abc84
https://doi.org/10.1073/pnas.1706818114
https://doi.org/10.1073/pnas.1706818114
Autor:
Hala Chaaban, Robert Silasi-Mansat, Mark K. Coggeshall, Florea Lupu, Demarco Steven James, Marybeth Langer, Narcis I. Popescu, Cristina Lupu, Ravi S. Keshari
Publikováno v:
Blood. 126:765-765
Complement is a "dual-edged sword" that is critical for the innate immunity against pathogens, but its uncontrolled activation contributes to disseminated intravascular coagulation (DIC), inflammation, cell death, immune paralysis and cardiac dysfunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7f0f808b0f24db96affdbfc96794720
https://doi.org/10.1182/blood.v126.23.765.765
https://doi.org/10.1182/blood.v126.23.765.765
Autor:
Douglas A. Treco, Dhamnaskar Ketki Ashok, Kathleen Seyb, Demarco Steven James, Vaishnavi Rajagopal, Michelle Denise Arata, Masha Fridkis-Hareli, Guo-Qing Tang, Hammer Robert Paul, Alonso Ricardo, Sylvia Tobe
Publikováno v:
Blood. 126:939-939
Regulation of the terminal phase of the complement component pathway is a clinically validated approach for the therapeutic treatment of complement disorders. Inhibition of complement activation at the C5 level with the monoclonal antibody eculizumab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1a6558f3c22d74c96a694c42bad48f0
https://doi.org/10.1182/blood.v126.23.939.939
https://doi.org/10.1182/blood.v126.23.939.939
Autor:
Demarco Steven James, Cristina Lupu, Robert Silasi-Mansat, Ravi S. Keshari, Hala Chaaban, Florea Lupu, Narcis I. Popescu
Publikováno v:
Blood. 124:112-112
Bacterial sepsis triggers robust early activation of the complement system that leads to the formation of the C5b-9 terminal complex (TCC) and potent proinflammatory anaphylatoxins, C3a and C5a, which significantly contribute to organ failure and dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f168877164826b057bc6ef4ce7989dd
https://doi.org/10.1182/blood.v124.21.112.112
https://doi.org/10.1182/blood.v124.21.112.112
Autor:
Dhamnaskar Ketki Ashok, Hammer Robert Paul, Hong Zheng, Zhaolin Wang, Sylvia Tobe, Kristopher Josephson, Douglas A. Treco, Michelle Denise Arata, Alonso Ricardo, Demarco Steven James, Kathleen Seyb
Publikováno v:
Blood. 124:2936-2936
The involvement of complement in the pathogenesis of serious, life-threatening diseases underscores the importance in developing therapeutics to intervene in this cascade. Specifically, dysregulation of the complement system is central in multiple he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22e4e7c8a403b703d9aeac28dd509e53
https://doi.org/10.1182/blood.v124.21.2936.2936
https://doi.org/10.1182/blood.v124.21.2936.2936