Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dema Najem"'
Publikováno v:
Neuroscience Bulletin. 32:227-238
Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) toxicity, tau pathology, insulin resistance, neuroinflammation, and dysregulation of cholesterol homeostasis, all of which play roles in neurodegeneration. Insulin has polytrophic effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5c0c56a7eb095faf59ad3cf4160040
https://doi.org/10.1007/s12264-016-0034-9
https://doi.org/10.1007/s12264-016-0034-9
Autor:
Evan Dorey, Dema Najem, Douglas G. Walker, Lih-Fen Lue, Danica Stanimirovic, Yan Li, Debbie Callaghan, Hong Liu, Michelle Bamji-Mirza, Wandong Zhang
Neuroinflammation plays a critical role in neuronal dysfunction and death of Alzheimer's disease (AD). ApoE4 is a major risk factor of AD, while ApoE2 is neuroprotective. Little is known about the roles of ApoE isoforms in the neuroinflammation seen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8d57ef4bd3005d0a1494061c84ac0e
https://nrc-publications.canada.ca/eng/view/object/?id=78f57561-0310-4b77-861f-b9a22981b766
https://nrc-publications.canada.ca/eng/view/object/?id=78f57561-0310-4b77-861f-b9a22981b766
Autor:
Maria Ribecco-Lutkiewicz, Julie Haukenfrers, Kerry Rennie, Munyao Nzau, Qing Liu, Mahmud Bani-Yaghoub, Dema Najem, Dao Ly, Douglas D. Fraser
Publikováno v:
Paediatrics Publications
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. Due to its high incidence rate and often long-term sequelae, TBI contributes significantly to increasing costs of health care expenditures annually. Unfortunately,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e075bb2c01b2951616428c7341aed908
https://pubmed.ncbi.nlm.nih.gov/29370536
https://pubmed.ncbi.nlm.nih.gov/29370536
Autor:
Dema Najem, Debbie Callaghan, Wandong Zhang, Michelle Bamji-Mirza, Mohamed Shaad Hasim, Shanshan Shen, Ze Yang
Publikováno v:
Journal of Alzheimer's Disease. 40:105-122
One of the hallmarks of Alzheimer's disease (AD) is the accumulation and deposition of amyloid-β (Aβ) peptides in the brain and cerebral vasculature. Aβ evokes neuroinflammation and has been implicated in insulin signaling disruption and JNK-AP1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b22da0b1e2437ee7fd4033cc6048cc
https://doi.org/10.3233/jad-131949
https://doi.org/10.3233/jad-131949
Autor:
Jianjun Li, Wandong Zhang, Ekaterina Rogaeva, Ze Yang, Qing Yan Liu, Michelle Bamji-Mirza, Yan Li, Lih-Fen Lue, Mahdi Ghani, Dema Najem, Kenneth Chan, Jacek Stupak, Douglas G. Walker
Publikováno v:
Journal of Alzheimer's disease : JAD. 53(3)
Alzheimer’s disease (AD) is characterized by extracellular deposits of amyloid-β (Aβ) in the brain. ABCA7 is highly expressed in the brain and a susceptibility gene for late-onset AD (LOAD). The minor alleles at two ABCA7 single-nucleotide polymo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2991507799ad659877fd61edfcf1d4b
https://pubmed.ncbi.nlm.nih.gov/27314524
https://pubmed.ncbi.nlm.nih.gov/27314524
Autor:
Felipe Mangoni Moretti, Caroline Sodja, Maria Ribecco-Lutkiewicz, Mahmud Bani-Yaghoub, Dema Najem, Danica Stanimirovic
Publikováno v:
Fetal Stem Cells in Regenerative Medicine ISBN: 9781493934812
In the last decade, amniotic fluid (AF) has gained extensive attention as a source of stem cells with potential applications in pharmaceutical screening, disease modeling and cell-based therapies. In particular, the routine collection of AF through a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d591893007ab00278aedb34e2de02780
https://doi.org/10.1007/978-1-4939-3483-6_10
https://doi.org/10.1007/978-1-4939-3483-6_10
Publikováno v:
Alzheimer's & Dementia. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55803d57f25d45532b7a7e8d88d5d7b8
https://doi.org/10.1016/j.jalz.2014.04.398
https://doi.org/10.1016/j.jalz.2014.04.398
Publikováno v:
Reviews in the neurosciences. 25(4)
Alzheimer's disease (AD) is the most common form of dementia. Pathologically, it is characterized by degeneration of neurons and synapses, the deposition of extracellular plaques consisting of aggregated amyloid-â (Aâ) peptides, and intracellular n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b032418c7524f6ec926ea8ef8dacc7
https://pubmed.ncbi.nlm.nih.gov/24622783
https://pubmed.ncbi.nlm.nih.gov/24622783