Peptide vaccination directed against IDO1-expressing immune cells elicits CD8+ and CD4+ T-cell-mediated antitumor immunity and enhanced anti-PD1 responses

Autor: Mads Hald Andersen, Souvik Dey, Erika Sutanto-Ward, Katharina L Kopp, James DuHadaway, Arpita Mondal, Dema Ghaban, Inés Lecoq, Mai-Britt Zocca, Lauren M F Merlo, Laura Mandik-Nayak, Ayako Wakatsuki Pedersen, Alexander J Muller

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which subverts T-cell immunity at multiple levels, is itself subject to inherent T-cell reactivity. This intriguing deviation from central tolerance has been interpre

Externí odkaz: https://doaj.org/article/85b92312e7ef499e81e377e49eedf1d5

Peptide vaccination directed against IDO1-expressing immune cells elicits CD8 + and CD4 + T-cell-mediated antitumor immunity and enhanced anti-PD1 responses

Autor: James B. DuHadaway, Erika Sutanto-Ward, Dema Ghaban, Lauren M.F. Merlo, Arpita Mondal, Mads Hald Andersen, Ayako Wakatsuki Pedersen, Laura Mandik-Nayak, Souvik Dey, Katharina L. Kopp, Inés Lecoq, Alexander J. Muller, Mai-Britt Zocca

Publikováno v: Dey, S, Sutanto-Ward, E, Kopp, K L, Duhadaway, J, Mondal, A, Ghaban, D, Lecoq, I, Zocca, M B, Merlo, L M F, Mandik-Nayak, L, Andersen, M H, Pedersen, A W & Muller, A J 2020, ' Peptide vaccination directed against IDO1-expressing immune cells elicits CD8 + and CD4 + T-cell-mediated antitumor immunity and enhanced anti-PD1 responses ', Journal for ImmunoTherapy of Cancer, vol. 8, no. 2, 2020000605 . https://doi.org/10.1136/jitc-2020-000605
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

BackgroundThe tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which subverts T-cell immunity at multiple levels, is itself subject to inherent T-cell reactivity. This intriguing deviation from central tolerance has been interpret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24213c5586cc584ecdd188e8c7c16e98
https://curis.ku.dk/ws/files/258770834/e000605.full.pdf