Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Delyth Graham"'
Autor:
Sarah McNeilly, Cameron R. Thomson, Laura Gonzalez-Trueba, Yuan Yan Sin, Alessandra Granata, Graham Hamilton, Michelle Lee, Erin Boland, John D. McClure, Cristina Lumbreras-Perales, Alisha Aman, Apoorva A. Kumar, Marco Cantini, Caglar Gök, Delyth Graham, Yasuko Tomono, Christopher D. Anderson, Yinhui Lu, Colin Smith, Hugh S. Markus, Marc Abramowicz, Catheline Vilain, Rustam Al-Shahi Salman, Manuel Salmeron-Sanchez, Atticus H. Hainsworth, William Fuller, Karl E. Kadler, Neil J. Bulleid, Tom Van Agtmael
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105315- (2024)
Summary: Background: Genetic variants in COL4A1 and COL4A2 (encoding collagen IV alpha chain 1/2) occur in genetic and sporadic forms of cerebral small vessel disease (CSVD), a leading cause of stroke, dementia and intracerebral haemorrhage (ICH). Ho
Externí odkaz:
https://doaj.org/article/d38bd2e3219f479e9d1e302cbcbad3f9
Autor:
Leilei Cui, Bin Yang, Shijun Xiao, Jun Gao, Amelie Baud, Delyth Graham, Martin McBride, Anna Dominiczak, Sebastian Schafer, Regina Lopez Aumatell, Carme Mont, Albert Fernandez Teruel, Norbert Hübner, Jonathan Flint, Richard Mott, Lusheng Huang
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-25 (2023)
Abstract Background Dominance and other non-additive genetic effects arise from the interaction between alleles, and historically these phenomena play a major role in quantitative genetics. However, most genome-wide association studies (GWAS) assume
Externí odkaz:
https://doaj.org/article/c9f9298514244d73866514acd153094f
Autor:
Giacomo Rossitto, Sheon Mary, Jun Yu Chen, Philipp Boder, Khai Syuen Chew, Karla B. Neves, Rheure L. Alves, Augusto C. Montezano, Paul Welsh, Mark C. Petrie, Delyth Graham, Rhian M. Touyz, Christian Delles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Na+ has been suggested to accumulate in tissues, particularly skin, in a hypertonic manner and to exert local pathogenic effects. Here, we reappraise this phenomenon which is systemic in nature and reflects isotonic changes in the relative extracellu
Externí odkaz:
https://doaj.org/article/00f4143ef72e4165a258bfd5a79eca0e
Autor:
Augusto C. Montezano, Livia De Lucca Camargo, Patrik Persson, Francisco J. Rios, Adam P. Harvey, Aikaterini Anagnostopoulou, Roberto Palacios, Ana Caroline P. Gandara, Rheure Alves‐Lopes, Karla B. Neves, Maria Dulak‐Lis, Chet E. Holterman, Pedro Lagerblad de Oliveira, Delyth Graham, Christopher Kennedy, Rhian M. Touyz
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 12 (2018)
Background NADPH Oxidase 5 (Nox5) is a calcium‐sensitive superoxide‐generating Nox. It is present in lower forms and higher mammals, but not in rodents. Nox5 is expressed in vascular cells, but the functional significance remains elusive. Given t
Externí odkaz:
https://doaj.org/article/af22b1c36ce14d6cb666416e807846e5
Autor:
Sandosh Padmanabhan, Olle Melander, Toby Johnson, Anna Maria Di Blasio, Wai K Lee, Davide Gentilini, Claire E Hastie, Cristina Menni, Maria Cristina Monti, Christian Delles, Stewart Laing, Barbara Corso, Gerjan Navis, Arjan J Kwakernaak, Pim van der Harst, Murielle Bochud, Marc Maillard, Michel Burnier, Thomas Hedner, Sverre Kjeldsen, Björn Wahlstrand, Marketa Sjögren, Cristiano Fava, Martina Montagnana, Elisa Danese, Ole Torffvit, Bo Hedblad, Harold Snieder, John M C Connell, Morris Brown, Nilesh J Samani, Martin Farrall, Giancarlo Cesana, Giuseppe Mancia, Stefano Signorini, Guido Grassi, Susana Eyheramendy, H Erich Wichmann, Maris Laan, David P Strachan, Peter Sever, Denis Colm Shields, Alice Stanton, Peter Vollenweider, Alexander Teumer, Henry Völzke, Rainer Rettig, Christopher Newton-Cheh, Pankaj Arora, Feng Zhang, Nicole Soranzo, Timothy D Spector, Gavin Lucas, Sekar Kathiresan, David S Siscovick, Jian'an Luan, Ruth J F Loos, Nicholas J Wareham, Brenda W Penninx, Ilja M Nolte, Martin McBride, William H Miller, Stuart A Nicklin, Andrew H Baker, Delyth Graham, Robert A McDonald, Jill P Pell, Naveed Sattar, Paul Welsh, Global BPgen Consortium, Patricia Munroe, Mark J Caulfield, Alberto Zanchetti, Anna F Dominiczak
Publikováno v:
PLoS Genetics, Vol 6, Iss 10, p e1001177 (2010)
Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%-2% of the population variation in BP and hypertension. This suggests the existen
Externí odkaz:
https://doaj.org/article/57807fab5b1d4659bc82c7a7a71fbacc
Autor:
Janet Chamberlain, Sheila Francis, Zoe Brookes, Gary Shaw, Delyth Graham, Nicholas J Alp, Steven Dower, David C Crossman
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5073 (2009)
Atherosclerosis is an inflammatory process that develops in individuals with known risk factors that include hypertension and hyperlipidaemia, influenced by diet. However, the interplay between diet, inflammatory mechanisms and vascular risk factors
Externí odkaz:
https://doaj.org/article/1b95793e04be4e09ba8137b926614ab3
Publikováno v:
Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b52725781cd3d2ff73b9ccb1ee33b1d9
https://doi.org/10.1136/heartjnl-scf-2023.3
https://doi.org/10.1136/heartjnl-scf-2023.3
Autor:
Laura Haddow, Augusto C. Montezano, Karla B Neves, Rheure Alves-Lopes, Jennifer Dyet, Hiba Yusuf, Adam Harvey, Ross Hepburn, Delyth Graham, Wendy Beattie, John P. McAbney, Susan Haniford, Katie Y. Harvey, Anastasiya Strembitska
Publikováno v:
Clinical Science. 135:2429-2444
Osteogenic factors, such as osteoprotegerin (OPG), are protective against vascular calcification. However, OPG is also positively associated with cardiovascular damage, particularly in pulmonary hypertension, possibly through processes beyond effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91969c8fddb82fb7cfb8537025de7c5d
https://doi.org/10.1042/cs20210643
https://doi.org/10.1042/cs20210643
Autor:
Sheon Mary, Philipp Boder, Sandosh Padmanabhan, Martin W. McBride, Delyth Graham, Christian Delles, Anna F. Dominiczak
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 79(11)
The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in kidney and cardiovascular research. Genome-wide association studies discovered variants of uromodulin that are associated with chronic kidney diseases and hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85d3b208488c7960dc6e505c6f7053e
https://pubmed.ncbi.nlm.nih.gov/36378920
https://pubmed.ncbi.nlm.nih.gov/36378920
Autor:
Augusto C Montezano, Francisco J Rios, Zachariel Blaikie, Tomador E Saad, Livia Camargo, Wendy Beattie, Frederic Jaisser, Tomasz Guzik, Delyth Graham, Rhian M Touyz
Publikováno v:
Hypertension. 79
Mice expressing human Nox5 (hNox5) in VSMC exhibit cardfiovascular fibrosis, where mechanisms are unknown. We postulated that VSMC-Nox5 promotes fibroblast to myofibroblast differentiation that contributes to fibrosis. Fibroblasts were cultured from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4792be6ac0782406934a9fab4169067b
https://doi.org/10.1161/hyp.79.suppl_1.127
https://doi.org/10.1161/hyp.79.suppl_1.127