Rational Design of Dual-Domain Binding Inhibitors for N -Acetylgalactosamine Transferase 2 with Improved Selectivity over the T1 and T3 Isoforms.

Autor: Compañón I; Department of Chemistry and Instituto de Investigación en Química de la Universidad de La Rioja, Universidad de La Rioja, Logroño 26006, Spain., Ballard CJ; Department of Biochemistry, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, Ohio 44106, United States., Lira-Navarrete E; Department of Cellular and Molecular Medicine, Faculty of Health Sciences, Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen 2200, Denmark., Santos T; Department of Chemistry and Instituto de Investigación en Química de la Universidad de La Rioja, Universidad de La Rioja, Logroño 26006, Spain., Monaco S; School of Pharmacy, University of East Anglia, Norwich Research Park, NR4 7TJ Norwich, U.K., Muñoz-García JC; School of Pharmacy, University of East Anglia, Norwich Research Park, NR4 7TJ Norwich, U.K.; Instituto de Investigaciones Químicas, Consejo Superior de Investigaciones Científicas and Universidad de Sevilla, Avenida Américo Vespucio, 49, Sevilla 41092, Spain., Delso I; School of Pharmacy, University of East Anglia, Norwich Research Park, NR4 7TJ Norwich, U.K., Angulo J; School of Pharmacy, University of East Anglia, Norwich Research Park, NR4 7TJ Norwich, U.K.; Instituto de Investigaciones Químicas, Consejo Superior de Investigaciones Científicas and Universidad de Sevilla, Avenida Américo Vespucio, 49, Sevilla 41092, Spain., Gerken TA; Department of Biochemistry, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, Ohio 44106, United States.; Departments of Biochemistry and Chemistry, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, Ohio 44106, United States., Schjoldager KT; Department of Cellular and Molecular Medicine, Faculty of Health Sciences, Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen 2200, Denmark., Clausen H; Department of Cellular and Molecular Medicine, Faculty of Health Sciences, Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen 2200, Denmark., Tejero T; Department of Organic Chemistry, Faculty of Sciences, University of Zaragoza, Zaragoza 50009, Spain.; Institute of Chemical Synthesis and Homogeneous Catalysis, University of Zaragoza-CSIC, Zaragoza 50009, Spain., Merino P; Department of Organic Chemistry, Faculty of Sciences, University of Zaragoza, Zaragoza 50009, Spain.; Institute for Biocomputation and Physics of Complex Systems, University of Zaragoza, Zaragoza 50018, Spain., Corzana F; Department of Chemistry and Instituto de Investigación en Química de la Universidad de La Rioja, Universidad de La Rioja, Logroño 26006, Spain., Hurtado-Guerrero R; Department of Cellular and Molecular Medicine, Faculty of Health Sciences, Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen 2200, Denmark.; Institute for Biocomputation and Physics of Complex Systems, University of Zaragoza, Zaragoza 50018, Spain.; Fundación ARAID, Zaragoza 50018, Spain., Ghirardello M; Department of Chemistry and Instituto de Investigación en Química de la Universidad de La Rioja, Universidad de La Rioja, Logroño 26006, Spain.

Publikováno v: JACS Au [JACS Au] 2024 Sep 11; Vol. 4 (9), pp. 3649-3656. Date of Electronic Publication: 2024 Sep 11 (Print Publication: 2024).

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Nitrones and nucleobase-containing spiro-isoxazolidines derived from isatin and indanone: Solvent-free microwave-assisted stereoselective synthesis and theoretical calculations

Autor: Maiuolo, L., Merino, P., Algieri, V., Nardi, M., Di Gioia, M.L., Russo, B., Delso, I., Tallarida, M.A., De Nino, A.

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
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The spiro-oxindoles have found wide application because of their antiviral properties. However, in the literature few examples of synthesis of their precursors, oxindole-nitrones, are reported. In this paper, we initially present a rapid and efficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ba7e259de8b5490ae687e36b76f7e02a
http://zaguan.unizar.es/record/69752

FUT8-Directed Core Fucosylation of N-glycans Is Regulated by the Glycan Structure and Protein Environment.

Autor: García-García A; Institute of Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza 50018, Spain., Serna S; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, Donostia San Sebastián 20014, Spain., Yang Z; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen DK-2200, Denmark., Delso I; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., Taleb V; Institute of Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza 50018, Spain., Hicks T; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., Artschwager R; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, Donostia San Sebastián 20014, Spain., Vakhrushev SY; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen DK-2200, Denmark., Clausen H; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen DK-2200, Denmark., Angulo J; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.; Departamento de Química Orgánica, Universidad de Sevilla, Sevilla 41012, Spain.; Instituto de Investigaciones Químicas (CSIC-US), Avda. Américo Vespucio, 49, Seville 41092, Spain., Corzana F; Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, Logroño E-26006, Spain., Reichardt NC; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, Donostia San Sebastián 20014, Spain.; CIBER-BBN, Paseo Miramón 182, San Sebastian 20014, Spain., Hurtado-Guerrero R; Institute of Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza 50018, Spain.; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen DK-2200, Denmark.; Fundación ARAID, Zaragoza 50018, Spain.

Publikováno v: ACS catalysis [ACS Catal] 2021 Aug 06; Vol. 11 (15), pp. 9052-9065. Date of Electronic Publication: 2021 Jul 08.