Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Delshanee Kotandeniya"'
Publikováno v:
Journal of Chromatography B. 1007:121-126
A liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI+-MS/MS) method for the analysis of the tobacco-specific carcinogens N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and their gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be50040dee6c9dda29c54dd4b0958780
https://doi.org/10.1016/j.jchromb.2015.10.012
https://doi.org/10.1016/j.jchromb.2015.10.012
Autor:
Delshanee Kotandeniya, Yuk Y. Sham, Natalia Y. Tretyakova, Molly P Andersen, Zoe M. Koerperich, Jenna Fernandez, Christopher L. Seiler, Megin E. Nguyen
A precise balance of DNA methylation and demethylation is required for epigenetic control of cell identity, development, and growth. DNA methylation marks are introduced by de novo DNA methyltransferases DNMT3a/b and are maintained throughout cell di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f90f177b12cc01ba000722a84df7f3
https://europepmc.org/articles/PMC6310613/
https://europepmc.org/articles/PMC6310613/
Autor:
Sharon E. Murphy, Elizabeth A. Thompson, Makenzie E. Pillsbury, Benjamin W. S. Ransom, Steven G. Carmella, Delshanee Kotandeniya, Menglan Chen, Rachel Isaksson Vogel, Dorothy K. Hatsukami, Stephen S. Hecht
Publikováno v:
Nicotine & Tobacco Research. 17:704-709
Electronic cigarettes (e-cigarettes) are rapidly increasing in popularity but little information is available on their potential toxic or carcinogenic effects.Twenty-eight e-cigarette smokers who had not smoked tobacco cigarettes for at least 2 month
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b555584ea37eb85e42e68dc0d6561987
https://doi.org/10.1093/ntr/ntu218
https://doi.org/10.1093/ntr/ntu218
Autor:
Allison M. Land, Jason B. Nikas, Duncan E. Donohue, Rebecca M. McDougle, Emily K. Law, Brandon Leonard, Nuri A. Temiz, Anurag Rathore, Natalia Y. Tretyakova, Michael B. Burns, Delshanee Kotandeniya, Michael A. Carpenter, Douglas Yee, Eric W. Refsland, William L. Brown, Reuben S. Harris, Lela Lackey
Publikováno v:
Nature. 494:366-370
Several mutations are required for cancer development, and genome sequencing has revealed that many cancers, including breast cancer, have somatic mutation spectra dominated by C-to-T transitions. Most of these mutations occur at hydrolytically disfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3123c6693e0da60b36f6443a813c9cdd
https://doi.org/10.1038/nature11881
https://doi.org/10.1038/nature11881
Autor:
Natalia Y. Tretyakova, Delshanee Kotandeniya, Uthpala Seneviratne, Daniel P Murphy, Anthony E. Pegg, Rebecca Guza, Sreenivas Kanugula
Publikováno v:
Chemical Research in Toxicology. 24:1966-1975
O(6)-POB-dG (O(6)-[4-oxo-4-(3-pyridyl)but-1-yl]deoxyguanosine) are promutagenic nucleobase adducts that arise from DNA alkylation by metabolically activated tobacco-specific nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a31d6fef79dd6a0a330629f0575eb5
https://doi.org/10.1021/tx2002993
https://doi.org/10.1021/tx2002993
Autor:
Margarita Kessler, Zachary P. Fredin, Matthew S. Platz, Laura Pickard, James S. Poole, Kent S. Gates, Elisa Levya Guerrero, Goutam Chowdhury, Christopher M. Hadad, Delshanee Kotandeniya
Publikováno v:
Photochemistry and Photobiology. 75:339-345
The absorption and fluorescence spectra of 3-aminobenzo-1,2,4-triazine di-N-oxide (tirapazamine) have been recorded and exhibit a dependence on solvent that correlates with the Dimroth ET30 parameter. Time-dependent density functional theory calculat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3895d391b18d356e98ba26e391ff9a8
https://doi.org/10.1562/0031-8655(2002)0750339petrot2.0.co2
https://doi.org/10.1562/0031-8655(2002)0750339petrot2.0.co2
Autor:
Pramod Upadhyaya, Peter W. Villalta, Stephen S. Hecht, Adam T. Zarth, Delshanee Kotandeniya, Irina Stepanov, Bin Ma
Publikováno v:
Chemical Research in Toxicology
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) is a potent lung carcinogen in laboratory animals and is believed to play a key role in the development of lung cancer in smokers. Metabolic activation of NNK le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ea638f41235b551f9f95ffcb1214e9
https://pubmed.ncbi.nlm.nih.gov/26398225
https://pubmed.ncbi.nlm.nih.gov/26398225
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2325-2329
Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tumors. In this work, base excision repair enzymes were used to provide evidence that tirapazamine causes significant amounts of dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bc36eba9992aced6a74a255cd54bd8
https://doi.org/10.1016/s0960-894x(02)00468-7
https://doi.org/10.1016/s0960-894x(02)00468-7
Autor:
George M. Giambaşu, Shana J. Sturla, Thakshila Dissanayake, Roger Jones, Ryszard Jankowiak, Natalia Y. Tretyakova, Rahul R. Lad, Robert H. E. Hudson, Filip Wojciechowski, Chen Lin, Delshanee Kotandeniya, Shantu Amin, Rebecca Guza, Kristopher Murphy, Darrin M. York
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 39 (9)
Nucleic Acids Research, 39 (9)
Endogenous 5-methylcytosine ((Me)C) residues are found at all CG dinucleotides of the p53 tumor suppressor gene, including the mutational 'hotspots' for smoking induced lung cancer. (Me)C enhances the reactivity of its base paired guanine towards car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7e52098dbeb061bc465cf1dd052dc6
Publikováno v:
Chemical research in toxicology. 17(11)
The compound 3-amino-2-quinoxalinecarbonitrile 1,4-dioxide (4) displays potent hypoxia-selective cytotoxicity in cell culture. This compound is structurally similar to the known hypoxia-selective DNA-damaging agent tirapazamine (1, TPZ), but the abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8129e13b01547e4b1ea6a9e55a837d4b
https://pubmed.ncbi.nlm.nih.gov/15540937
https://pubmed.ncbi.nlm.nih.gov/15540937