High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis

Autor: Adil Maarouf, Delphine Stephan, Marie-Pierre Ranjeva, Jean-Philippe Ranjeva, Jean Pelletier, Bertrand Audoin, Michel Khrestchatisky, Sophie Desplat-Jégo

Publikováno v: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-10 (2019)

Abstract Background Inflammation and demyelination are the main processes in multiple sclerosis. Nevertheless, to date, blood biomarkers of inflammation are lacking. TWEAK, a transmembrane protein that belongs to the TNF ligand family, has been previ

Externí odkaz: https://doaj.org/article/4697ee5ef7154e44a5da2a69d3fdb36c

Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury.

Autor: Jean-Francois Chabas, Delphine Stephan, Tanguy Marqueste, Stephane Garcia, Marie-Noelle Lavaut, Catherine Nguyen, Regis Legre, Michel Khrestchatisky, Patrick Decherchi, Francois Feron

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e65034 (2013)

Previously, we demonstrated i) that ergocalciferol (vitamin D2) increases axon diameter and potentiates nerve regeneration in a rat model of transected peripheral nerve and ii) that cholecalciferol (vitamin D3) improves breathing and hyper-reflexia i

Externí odkaz: https://doaj.org/article/605f5ed37d01487db45f645aa5ab6522

APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation

Autor: Laurie, Arnaud, Philippe, Benech, Louise, Greetham, Delphine, Stephan, Angélique, Jimenez, Nicolas, Jullien, Laura, García-González, Philipp O, Tsvetkov, François, Devred, Ignacio, Sancho-Martinez, Juan Carlos, Izpisua Belmonte, Kévin, Baranger, Santiago, Rivera, Emmanuel, Nivet

Publikováno v: Cell reports. 40(7)

Apolipoprotein E4 (APOEε4) is the major allelic risk factor for late-onset sporadic Alzheimer's disease (sAD). Inflammation is increasingly considered as critical in sAD initiation and progression. Identifying brain molecular mechanisms that could b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0874beb9daf049ed8771e921d03aaaf5
https://pubmed.ncbi.nlm.nih.gov/35977506

MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer's disease

Autor: Dominika, Pilat, Jean-Michel, Paumier, Laura, García-González, Laurence, Louis, Delphine, Stephan, Christine, Manrique, Michel, Khrestchatisky, Eric, Di Pasquale, Kévin, Baranger, Santiago, Rivera

Publikováno v: Journal of neuroinflammation. 19(1)

Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease (AD) reduces brain neuroinflammation and amyloidosis, and prevents deficits in synaptic activity and cognition in prodromal stages of the di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6f15c2c76f2c85b4ee6236ecb84b905
https://pubmed.ncbi.nlm.nih.gov/35277173

The influence of vitamin D on neurodegeneration and neurological disorders: a rationale for its physio-pathological actions

Autor: Rossella Zenobi, Francois Feron, Pascal Millet, Delphine Stephan, Maria Morello, Massimo Pieri, Alessandra Talamo, Véréna Landel

Publikováno v: Current Pharmaceutical Design
Current Pharmaceutical Design, Bentham Science Publishers, 2020, 26, ⟨10.2174/1381612826666200316145725⟩
Current Pharmaceutical Design, 2020, 26, ⟨10.2174/1381612826666200316145725⟩

Vitamin D is a steroid hormone implicated in the regulation of neuronal integrity and many brain functions. Its influence, as a nutrient and a hormone, on the physiopathology of the most common neurodegenerative diseases is continuously emphasized by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e0164eefdbf9e17eb0be070b3b315f
https://hal.archives-ouvertes.fr/hal-02869329