Rapamycin-Loaded Lipid Nanocapsules Induce Selective Inhibition of the mTORC1-Signaling Pathway in Glioblastoma Cells

Autor: Delphine Séhédic, Loris Roncali, Amel Djoudi, Nela Buchtova, Sylvie Avril, Michel Chérel, Frank Boury, Franck Lacoeuille, François Hindré, Emmanuel Garcion

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)

Inhibition of the PI3K/Akt/mTOR signaling pathway represents a potential issue for the treatment of cancer, including glioblastoma. As such, rapamycin that inhibits the mechanistic target of rapamycin (mTOR), the downstream effector of this signaling

Externí odkaz: https://doaj.org/article/7c81110c7cf344ad983d8b3c79d577c7

The Melanoma Antigens MELOE-1 and MELOE-2 Are Translated from a Bona Fide Polycistronic mRNA Containing Functional IRES Sequences

Autor: Wolfgang Mikulits, Laetitia Florenceau, Agnès Moreau-Aubry, Nathalie Labarrière, Delphine Carbonnelle, Maud Charpentier, François Lang, Delphine Sehedic, Virginie Vignard

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (9), pp.e75233. ⟨10.1371/journal.pone.0075233⟩
PLoS ONE, Vol 8, Iss 9, p e75233 (2013)
PLoS ONE, 2013, 8 (9), pp.e75233. ⟨10.1371/journal.pone.0075233⟩

International audience; Our previous studies on melanoma antigens identified two new polypeptides, named MELOE-1 and MELOE-2, that are involved in immunosurveillance. Intriguingly, these antigens are coded by distinct open reading frames (ORF) of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0cf9d504021358654030934bd9e6bc
https://www.hal.inserm.fr/inserm-01726993