Zobrazeno 1 - 1
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pro vyhledávání: '"Delphine Rivron"'
Autor:
Anthony Nichols, David Covini, Anna Quattropani, Jean-François Arrighi, Yves Cambet, Maurizio Maio, Thierry Martin, Olivier Schott, Bernard Françon, Laurence Novo-Perez, Don Simpson, Delphine Marin, Delphine Rivron, Cristina Donini, Agnes Bombrun, Pierre-Alain Vitte, Stefano Crosignani, Wolfgang H. B. Sauer, Isabelle Martinou, Dominique Swinnen, Valerie Eligert, Fabienne Burgat-Charvillon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1516-1519
The discovery of a novel series of S1P1 agonists is described. Starting from a micromolar HTS positive, iterative optimization gave rise to several single-digit nanomolar S1P1 agonists. The compounds were able to induce internalization of the S1P1 re