Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells

Autor: Erika Cecon, Atsuro Oishi, Marine Luka, Delphine Ndiaye-Lobry, Arnaud François, Mathias Lescuyer, Fany Panayi, Julie Dam, Patricia Machado, Ralf Jockers

Publikováno v: eLife, Vol 12 (2023)

Aggregates of the tau protein are a well-known hallmark of several neurodegenerative diseases, collectively referred to as tauopathies, including frontal temporal dementia and Alzheimer’s disease (AD). Monitoring the transformation process of tau f

Externí odkaz: https://doaj.org/article/60b46b54a6b242a9afabff8b315dade9

A glycosphingolipid binding domain controls trafficking and activity of the mammalian notch ligand delta-like 1.

Autor: Sara Farrah Heuss, Nadine Tarantino, Jacques Fantini, Delphine Ndiaye-Lobry, Julien Moretti, Alain Israël, Frédérique Logeat

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74392 (2013)

The activity of Notch ligands is tightly regulated by trafficking events occurring both before and after ligand-receptor interaction. In particular endocytosis and recycling have been shown to be required for full signaling activity of the ligands be

Externí odkaz: https://doaj.org/article/a9c4afcbb02545b48b009a47e8d67df4

Author response: Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells

Autor: Erika Cecon, Atsuro Oishi, Marine Luka, Delphine Ndiaye-Lobry, Arnaud François, Mathias Lescuyer, Fany Panayi, Julie Dam, Patricia Machado, Ralf Jockers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c28dd513e62c387bd26cae4032b9823
https://doi.org/10.7554/elife.78360.sa2

Pharmacological evidence for transactivation within melatonin MT 2 and serotonin 5‐HT 2C receptor heteromers in mouse brain

Autor: Delphine Ndiaye-Lobry, Florence Gbahou, Lora K. Heisler, Erika Cecon, Ralf Jockers, Pablo B. Martínez de Morentin, Philippe Delagrange, Romain Gerbier

Publikováno v: The FASEB Journal. 35

Association of G protein-coupled receptors into heterodimeric complexes has been reported for over 50 receptor pairs in vitro but functional in vivo validation remains a challenge. Our recent in vitro studies defined the functional fingerprint of het

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85abc8f9b329e6b4dc9e256e2e055638
https://doi.org/10.1096/fj.202000305r

Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

Autor: Raffaella Di Micco, Giulia Schiroli, Valentina Vavassori, Anastasia Conti, Pietro Genovese, Delphine Ndiaye-Lobry, Patrizia Gasparini, Julie Chaumeil, Chiara Brombin, Lucrezia della Volpe, Ivan Merelli, Aurelien Jacob, Eugenio Montini, Andrea Calabria, Samuele Ferrari, Luigi Naldini, Stefano Beretta, Luisa Albano, Eralda Salataj

Publikováno v: Cell stem cell
(2019). doi:10.1016/j.stem.2019.02.019
info:cnr-pdr/source/autori:Schiroli G, Conti A, Ferrari S, Della Volpe L, Jacob A, Albano L, Beretta S, Calabria A, Vavassori V, Gasparini P, Salataj E, Ndiaye-Lobry D, Brombin C, Chaumeil J, Montini E, Merelli I, Genovese P, Naldini L, Di Micco R./titolo:Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response/doi:10.1016%2Fj.stem.2019.02.019/rivista:Cell stem cell (Print)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume

Precise gene editing in hematopoietic stem and progenitor cells (HSPCs) holds promise for treating genetic diseases. However, responses triggered by programmable nucleases in HSPCs are poorly characterized and may negatively impact HSPC engraftment a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e2c115a7ee7581180ef11317f7beb1
https://doi.org/10.1016/j.stem.2019.02.019