Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system

Autor: Gemma Llufriu-Dabén, Alex Carrete, Elena Chierto, Jo Mailleux, Emeline Camand, Anne Simon, Tim Vanmierlo, Christiane Rose, Bernadette Allinquant, Jerome J.A. Hendriks, Charbel Massaad, Delphine Meffre, Mehrnaz Jafarian-Tehrani

Publikováno v: Neurobiology of Disease, Vol 109, Iss , Pp 11-24 (2018)

Remyelination is an endogenous regenerative process of myelin repair in the central nervous system (CNS) with limited efficacy in demyelinating disorders. As strategies enhancing endogenous remyelination become a therapeutic challenge, we have focuse

Externí odkaz: https://doaj.org/article/c262bbe9326f41d4820553374b0a7fec

Effect of Etazolate upon Cuprizone-induced Demyelination In Vivo: Behavioral and Myelin Gene Analysis

Autor: Anne Simon, Alex Carrete, Mehrnaz Jafarian-Tehrani, Aïda Padilla-Ferrer, Delphine Meffre

Publikováno v: Neuroscience. 455

Demyelination is a well-known pathological process in CNS disorders such as multiple sclerosis (MS). It provokes progressive axonal degeneration and functional impairments and no efficient therapy is presently available to combat such insults. Recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633508ab2e46af7ac0465d5610e3fdab
https://pubmed.ncbi.nlm.nih.gov/33246058

Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system

Autor: Mehrnaz Jafarian-Tehrani, Anne Simon, Gemma Llufriu-Dabén, Christiane Rose, Jo Mailleux, Delphine Meffre, Emeline Camand, Bernadette Allinquant, Alex Carrete, Elena Chierto, Jerome J. A. Hendriks, Charbel Massaad, Tim Vanmierlo

Publikováno v: Neurobiology of Disease, Vol 109, Iss, Pp 11-24 (2018)

Remyelination is an endogenous regenerative process of myelin repair in the central nervous system (CNS) with limited efficacy in demyelinating disorders. As strategies enhancing endogenous remyelination become a therapeutic challenge, we have focuse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270bd4fc57e885fa338b00cd1522477b
https://doi.org/10.1016/j.nbd.2017.09.008

Mechanical Stretch of High Magnitude Provokes Axonal Injury, Elongation of Paranodal Junctions, and Signaling Alterations in Oligodendrocytes

Autor: Didier Borderie, Mehrnaz Jafarian-Tehrani, Elena Chierto, Giulia Cristinziano, Delphine Meffre, Francesca Castoldi, François Etienne, Anne Simon, François Rannou, Barclay Morrison, Francesca Sapone, Charbel Massaad, Alex Carrete

Publikováno v: Molecular Neurobiology

Increasing findings suggest that demyelination may play an important role in the pathophysiology of brain injury, but the exact mechanisms underlying such damage are not well known. Mechanical tensile strain of brain tissue occurs during traumatic br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14aa096e5394243cbba2ea4ce43dd1c1
https://pubmed.ncbi.nlm.nih.gov/30298339

The Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis

Autor: Ludmila Juricek, Charbel Massaad, Frédéric Charbonnier, Mehdi Hichor, Ingrid Laurendeau, Eric Pasmant, Etienne-Emile Baulieu, Ivan Bièche, Marc Herbin, Xavier Coumoul, Frédérique Larousserie, Mathieu Beraneck, Laure Weill, Nicolas Ortonne, Nirmal Kumar Sampathkumar, Ghjuvan’Ghjacumu Shackleford, Delphine Meffre, Aline Chevallier

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (6), pp.E1319-E1328. ⟨10.1073/pnas.1715999115⟩

International audience; Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in xenobiotic metabolism. Plexiform neurofibromas (PNFs) can transform into malignant peripheral nerve sheath tumors (MPNSTs) that are resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415b8b9263a900cb2b52ff1ba86622e7
https://hal.archives-ouvertes.fr/hal-02110942