Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Delphine M, Lees"'
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Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth
Autor: Louise E. Reynolds, Beatriz de Luxan Delgado, Jesus Gomez-Escudero, Pedro R. Cutillas, Emma Newport, Vinothini Rajeeve, Ana Rita Pedrosa, Kairbaan Hodivala-Dilke, Matthew Dukinfield, Delphine M. Lees, Pedro Casado, Edward P. Carter, Stephen W Duffy
Publikováno v: The Journal of pathologyReferences. 256(2)
A common limitation of cancer treatments is chemotherapy resistance. We have previously identified that endothelial cell (EC)-specific deletion of focal adhesion kinase (FAK) sensitises tumour cells to DNA-damaging therapies, reducing tumour growth i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c736db297e770861ca72f8fd97a5192
https://pubmed.ncbi.nlm.nih.gov/34743335
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7
Akademický článek
Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth.
Autor: Marianne Baker, Louise E Reynolds, Stephen D Robinson, Delphine M Lees, Maddy Parsons, George Elia, Kairbaan Hodivala-Dilke
Publikováno v: PLoS ONE, Vol 8, Iss 5, p e62516 (2013)
The maintenance of endothelial cell-cell junctions is vital for the control of blood vessel leakage and is known to be important in the growth and maturation of new blood vessels during angiogenesis. Here we have investigated the role of a tight junc
Externí odkaz: https://doaj.org/article/65ff3c9f977a4399ac2c953da2c108a7
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8
Generation of point-mutant FAK knockin mice
Autor: Delphine M. Lees, Bernardo Tavora, Isabelle Fernandez, Silvia Batista, Stephen D. Robinson, Kairbaan Hodivala-Dilke, Bryan Serrels, Vassiliki Kostourou, Annika N. Alexopoulou
Publikováno v: genesis. 52:907-915
Summary Focal adhesion kinase is a non-receptor protein tyrosine kinase with signaling functions downstream of integrins and growth factor receptors. In addition to its role in adhesion, migration, and proliferation it also has non-kinase scaffolding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6835c8f9d6d27665c8127d0da542e73
https://doi.org/10.1002/dvg.22823
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9
Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice
Autor: Annika N, Alexopoulou, Delphine M, Lees, Natalia, Bodrug, Tanguy, Lechertier, Isabelle, Fernandez, Gabriela, D'Amico, Matthew, Dukinfield, Silvia, Batista, Bernardo, Tavora, Bryan, Serrels, Kairbaan, Hodivala-Dilke
Publikováno v: The Journal of Pathology
Focal adhesion kinase (FAK) inhibitors have been developed as potential anticancer agents and are undergoing clinical trials. In vitro activation of the FAK kinase domain triggers autophosphorylation of Y397, Src activation, and subsequent phosphoryl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd80e35ec4b818a6fab319df5cf7e05b
https://pubmed.ncbi.nlm.nih.gov/28444899
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10
Regulation of Vascular Endothelial Function by Procyanidin-Rich Foods and Beverages
Autor: Mark R. Pothecary, Gurvinder Rull, Roger Corder, Elizabeth G. Wood, Tomomasa Kanda, Toshihiko Shoji, Delphine M. Lees, Paul W. Caton, Noorafza Q. Khan
Publikováno v: Journal of Agricultural and Food Chemistry. 58:4008-4013
Flavonoid-rich diets are associated with a lower mortality from cardiovascular disease. This has been linked to improvements in endothelial function. However, the specific flavonoids, or biologically active metabolites, conferring these beneficial ef
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbab54755f4bbb11afa475dca0d276b
https://doi.org/10.1021/jf9031876
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