Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Delphine Lavens"'
Autor:
Isabel Uyttendaele, Delphine Lavens, Dominiek Catteeuw, Irma Lemmens, Celia Bovijn, Jan Tavernier, Frank Peelman
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44143 (2012)
The mammalian two-hybrid system MAPPIT allows the detection of protein-protein interactions in intact human cells. We developed a random mutagenesis screening strategy based on MAPPIT to detect mutations that disrupt the interaction of one protein wi
Externí odkaz:
https://doaj.org/article/20828a115ea64a488c5ed8a5b79cd023
Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis
Autor:
Delphine Lavens, Frank Peelman, José Van der Heyden, Isabel Uyttendaele, Dominiek Catteeuw, Annick Verhee, Bertrand Van Schoubroeck, Julia Kurth, Sabine Hallenberger, Reginald Clayton, Jan Tavernier
Publikováno v:
Nucleic Acids Research
NUCLEIC ACIDS RESEARCH
NUCLEIC ACIDS RESEARCH
The host restriction factor Apobec3G is a cytidine deaminase that incorporates into HIV-1 virions and interferes with viral replication. The HIV-1 accessory protein Vif subverts Apobec3G by targeting it for proteasomal degradation. We propose a model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f1b9d202a378d8b09826ca0f7b9894
https://doi.org/10.1093/nar/gkp1154
https://doi.org/10.1093/nar/gkp1154
Autor:
Anne-Sophie De Smet, Irma Lemmens, Joël Vandekerckhove, Annick Verhee, Jan Tavernier, Frank Peelman, Isabel Uyttendaele, Delphine Lavens
Publikováno v:
Molecular Endocrinology. 21:2821-2831
Binding of GH to its receptor induces rapid phosphorylation of conserved tyrosine motifs that function as recruitment sites for downstream signaling molecules. Using mammalian protein-protein interaction trap (MAPPIT), a mammalian two-hybrid method,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596a480657abf04a4ef66c99a6e94688
https://doi.org/10.1210/me.2006-0541
https://doi.org/10.1210/me.2006-0541
Autor:
Tony Montoye, Kris Gevaert, Julie Piessevaux, Lennart Zabeau, Sven Eyckerman, Walter Becker, Joël Vandekerckhove, Delphine Lavens, Jan Tavernier
Publikováno v:
Journal of Cell Science. 119:2214-2224
Hypothalamic leptin receptor signalling plays a central role in weight regulation by controlling fat storage and energy expenditure. In addition, leptin also has direct effects on peripheral cell types involved in regulation of diverse body functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8de37625a2d0419c352cfcc4e20076
https://doi.org/10.1242/jcs.02947
https://doi.org/10.1242/jcs.02947
Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines
Autor:
Jan Tavernier, Paul Hekerman, Hans-Georg Joost, Julia Zeidler, Simone Bamberg-Lemper, Delphine Lavens, Holger Knobelspies, Walter Becker
Publikováno v:
FEBS Journal. 272:109-119
The leptin receptor (LEPR) is a class I cytokine receptor signalling via both the janus kinase/signal transducer and activator of transcription (JAK/STAT) and the MAP kinase pathways. In addition, leptin has been shown previously to activate AMP-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edb9368fb35d023b7938a105bb410e8b
https://doi.org/10.1111/j.1432-1033.2004.04391.x
https://doi.org/10.1111/j.1432-1033.2004.04391.x
Autor:
Jan Tavernier, Delphine Lavens, Irma Lemmens, Frank Peelman, Dominiek Catteeuw, Celia Bovijn, Isabel Uyttendaele
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44143 (2012)
PLoS ONE
PLoS ONE
The mammalian two-hybrid system MAPPIT allows the detection of protein-protein interactions in intact human cells. We developed a random mutagenesis screening strategy based on MAPPIT to detect mutations that disrupt the interaction of one protein wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2b5bc0a0d1a40c809f03f613f1d68d
http://europepmc.org/articles/PMC3438196?pdf=render
http://europepmc.org/articles/PMC3438196?pdf=render
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 517
The mammalian protein-protein interaction trap (MAPPIT) is a two-hybrid technique founded on type I cytokine signal transduction. Thereby, bait and prey proteins are linked to signalling deficient cytokine receptor chimeras. Interaction of bait and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::379208b9f111bf450f8153a012814e81
https://pubmed.ncbi.nlm.nih.gov/19378012
https://pubmed.ncbi.nlm.nih.gov/19378012
Publikováno v:
Cytokinegrowth factor reviews. 19(5-6)
The suppressors of cytokine signalling (SOCS) box is a structural domain found at the C-terminus of over 70 human proteins. It is usually coupled to a protein interaction module such as an SH2 domain in case of SOCS proteins, a family of modulators o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6bc1933f58d2a4cd574c47535fae22
https://pubmed.ncbi.nlm.nih.gov/18948053
https://pubmed.ncbi.nlm.nih.gov/18948053
Autor:
Delphine Lavens, Annick Verhee, Irma Lemmens, José Van der Heyden, Jan Tavernier, Sam Lievens, Sabine Hallenberger, Dirk Jochmans, Els Pattyn
Publikováno v:
Journal of virological methods. 153(1)
The high mutation rate of Human Immunodeficiency Virus (HIV) leads to the rapid derivation of compound-resistant virus strains and thus necessitates the identification and development of compounds with alternative mode of actions. MAPPIT (MAmmalian P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11d5a10301ff313989b03a0e10db6a9
https://pubmed.ncbi.nlm.nih.gov/18640157
https://pubmed.ncbi.nlm.nih.gov/18640157
Autor:
Dominiek Catteeuw, Julie Piessevaux, Delphine Lavens, Joris Wauman, Tony Montoye, Denise D. Belsham, Joël Vandekerckhove, Jan Tavernier, Frank Peelman
Publikováno v:
The Journal of biological chemistry. 281(44)
SOCS (suppressors of cytokine signaling) proteins are negative regulators of cytokine signaling that function primarily at the receptor level. Remarkably, in vitro and in vivo observations revealed both inhibitory and stimulatory effects of SOCS2 on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936a1419daff62f42e0a78bfd8a6e9b8
https://pubmed.ncbi.nlm.nih.gov/16956890
https://pubmed.ncbi.nlm.nih.gov/16956890