Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Delphine Launay"'
Autor:
Stéphanie Braillard, Delphine Launay, Nageswararao Pulakundam, Vikram Ramanathan, Bhavesh D. Patel, Rakshit Ameta, Jignesh P Patel, Ritika Uppal
Publikováno v:
Bioanalysis. 11:1419-1435
Aim: To develop a bioanalytical method to support pharmacokinetic evaluation of DNDI-VL-2098 in mouse, rat, dog and hamster following oral administration. Results & methodology: A robust LC–MS/MS bioanalytical method was developed to quantify DNDI-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c9b299214ce43917433931787218b7
https://doi.org/10.4155/bio-2019-0128
https://doi.org/10.4155/bio-2019-0128
Autor:
Andrew M. Thompson, Vanessa Yardley, Christopher B. Cooper, Stéphanie Braillard, Patrick D. O'Connor, William A. Denny, Louis Maes, Eric Chatelain, Zhenkun Ma, Delphine Launay, Scott G. Franzblau, Baojie Wan
Publikováno v:
ACS medicinal chemistry letters
ACS Med Chem Lett
ACS Med Chem Lett
[Image: see text] Antitubercular 7-substituted 2-nitroimidazo[2,1-b][1,3]oxazines were previously shown to exhibit potent antileishmanial and antitrypanosomal activities, culminating in a new clinical investigational drug for visceral leishmaniasis (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea87db18f03cfc7f6d4e1517b0ac15a3
https://hdl.handle.net/10067/1754160151162165141
https://hdl.handle.net/10067/1754160151162165141
Autor:
William A. Denny, Zhenkun Ma, Eric Chatelain, Scott G. Franzblau, Andrew J. Marshall, Stéphanie Braillard, Andrew M. Thompson, Delphine Launay, Christopher B. Cooper, Patrick D. O'Connor, Louis Maes, Vanessa Yardley, Baojie Wan, Suman Gupta
Publikováno v:
European journal of medicinal chemistry
Previous investigation of the potent antileishmanial properties of antitubercular 7-substituted 2-nitroimidazo[2,1-b][1,3]oxazines with biaryl side chains led to our development of a new clinical candidate for visceral leishmaniasis (DNDI-0690). With
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02702cc710bd500ba4022f894e749cd9
https://pubmed.ncbi.nlm.nih.gov/33268145
https://pubmed.ncbi.nlm.nih.gov/33268145
Autor:
Sujata S. Shinde, Louis Maes, Yuehong Wang, Andrew M. Thompson, Delphine Launay, Eric Chatelain, Adrian Blaser, Baojie Wan, Brian D. Palmer, Scott G. Franzblau, Robert F. Anderson, William A. Denny, Zhenkun Ma
Publikováno v:
Bioorganic and medicinal chemistry letters
As part of a quest for backups to the antitubercular drug pretomanid (PA-824), we investigated the unexplored 6-nitro-2,3-dihydroimidazo[2,1-b][1,3]-thiazoles and related-oxazoles. The nitroimidazothiazoles were prepared in high yield from 2-bromo-4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e40f92b02df7872e8c069300f7307a
https://doi.org/10.1016/j.bmcl.2017.03.069
https://doi.org/10.1016/j.bmcl.2017.03.069
Autor:
Debnath Bhuniya, Rao Mukkavilli, Rahul Shivahare, Anil M. Deshpande, Ravindra T. Dere, Hari N. Pati, Vadiraj S. Gopinath, Ashok Pradhan, Manjunath Moger, Denis Martin, Suman Gupta, Preeti Vishwakarma, Delphine Launay, Aditya Verma, Sunil K. Puri
Publikováno v:
European Journal of Medicinal Chemistry. 102:582-593
As part of Drugs for Neglected Diseases initiative's lead optimization program for the development of new chemical entities to treat visceral leishmaniasis (VL), a series of aminothiazoles were synthesized and screened for in vitro efficacy, solubili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d74c1bfbd0b3139bc041f2c91536f9b
https://doi.org/10.1016/j.ejmech.2015.08.013
https://doi.org/10.1016/j.ejmech.2015.08.013
Autor:
Andrew M, Thompson, Andrew J, Marshall, Louis, Maes, Nigel, Yarlett, Cyrus J, Bacchi, Eric, Gaukel, Stephen A, Wring, Delphine, Launay, Stephanie, Braillard, Eric, Chatelain, Charles E, Mowbray, William A, Denny
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
A 900 compound nitroimidazole-based library derived from our pretomanid backup program with TB Alliance was screened for utility against human African trypanosomiasis (HAT) by the Drugs for Neglected Diseases initiative. Poten
A 900 compound nitroimidazole-based library derived from our pretomanid backup program with TB Alliance was screened for utility against human African trypanosomiasis (HAT) by the Drugs for Neglected Diseases initiative. Poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4bceeb112dd56a2963e71baeb9867c0
https://pubmed.ncbi.nlm.nih.gov/29191556
https://pubmed.ncbi.nlm.nih.gov/29191556
Autor:
Rama Mohan Hindupur, Delphine Launay, Srinivas A. Kandadai, Hari N. Pati, Vijay Satam, Pawan J. Tambade, Denis Martin, Srinivasa Rao Pedada
Publikováno v:
Organic Process Research & Development. 17:1149-1155
An efficient two-step method for the synthesis of 2-bromo-4-nitroimidazole, 6, a key building block for nitroimidazole drugs, has been developed. The synthesis involves dibromination of 4-nitroimidazole 10 followed by selective debromination using in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af332ba0c6125fe0250628146b19087
https://doi.org/10.1021/op400095f
https://doi.org/10.1021/op400095f
Autor:
Andrew M. Thompson, Apoorva Singh, Hari N. Pati, Vijay Satam, Pasumpon Kamaraj, Rama Mohan Hindupur, Delphine Launay, Nakita Antao, Denis Martin, Srinivasa Rao Pedada
Publikováno v:
Organic Process Research & Development
A process suitable for kilogram-scale synthesis of (2R)-2-methyl-6-nitro-2-{[4-(trifluoromethoxy)phenoxy]methyl}-2,3-dihydroimidazo[2,1-b][1,3]oxazole (DNDI-VL-2098, 2), a preclinical drug candidate for the treatment of visceral leishmaniasis, is des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748c40f323364e849e6fcdb6d86f0603
https://pubmed.ncbi.nlm.nih.gov/28539754
https://pubmed.ncbi.nlm.nih.gov/28539754
Autor:
Yuehong Wang, Delphine Launay, William A. Denny, Andrew M. Thompson, Zhenkun Ma, Scott G. Franzblau, Adrian Blaser, Louis Maes, Denis Martin, Baojie Wan, Suman Gupta, Patrick D. O'Connor, Vanessa Yardley
Publikováno v:
Journal of medicinal chemistry
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole derivatives were initially studied for tuberculosis within a backup program for the clinical trial agent pretomanid (PA-824). Phenotypic screening of representative examples against kinetoplastid diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f966f48c51da7efb91a561f6ab289a9a
https://hdl.handle.net/10067/1321150151162165141
https://hdl.handle.net/10067/1321150151162165141
Publikováno v:
Journal of Combinatorial Chemistry. 7:554-560
A polymer-supported analytical construct was used to quantify the reactivity of a range of monomers in the Ugi four-component condensation using positive electrospray ionization mass spectrometry (MS) as a quantitative analytical tool. The construct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5987c67c68b4074c4d5822fd58a22fa1
https://doi.org/10.1021/cc050013e
https://doi.org/10.1021/cc050013e