Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Delphine Gorses"'
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/1168651eade84aa68bb9c377c9befbde
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug d
Externí odkaz:
https://doaj.org/article/8f2eff537f564b01931321a688bb396a
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Fred Sigoillot, Scott Gleim, Marie-Therese Stachyra, Jason Thomas, Damien Begue, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Seth Carbonneau, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Bea Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Claudio R. Thoma
Targeted protein degradation (TPD) of neo-substrates with proteolysis targeting chimeras (PROTACs) or molecular glues has emerged as a key modality in exploring new biology as well as designing new drug candidates where catalytic inhibition is neithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b962ac1012caadf747a15217539d973e
https://doi.org/10.1101/2023.04.09.536153
https://doi.org/10.1101/2023.04.09.536153
Autor:
Leonid D. Konyushkin, Delphine Gorses, Alexander V. Samet, Victor V. Semenov, Marina N. Semenova, Arkady A. Dudinov, Evgenii N Khodot, Mikhail M. Krayushkin, Eugenia A. Silyanova, Alexei S. Karpov, Boris V. Lichitsky, Thomas Radimerski, Alex S. Kiselyov, Andrey N. Komogortsev
Publikováno v:
ACS Combinatorial Science. 21:805-816
1,3-Substituted pyrazolo[3,4-b]pyridinones 11-18 were synthesized by a three-component condensation of Meldrum's acid with aryl aldehydes and 1,3-substituted 5-aminopyrazoles. Their biological activity was evaluated using the in vivo phenotypic sea u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa5709419948b56c9ec086d82231691b
https://doi.org/10.1021/acscombsci.9b00135
https://doi.org/10.1021/acscombsci.9b00135
Autor:
Boris V, Lichitsky, Andrey N, Komogortsev, Arkady A, Dudinov, Mikhail M, Krayushkin, Evgenii N, Khodot, Alexander V, Samet, Eugenia A, Silyanova, Leonid D, Konyushkin, Alexei S, Karpov, Delphine, Gorses, Thomas, Radimerski, Marina N, Semenova, Alex S, Kiselyov, Victor V, Semenov
Publikováno v:
ACS combinatorial science. 21(12)
1,3-Substituted pyrazolo[3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f31200d714d9547f6e1612bdcaa16a9e
https://pubmed.ncbi.nlm.nih.gov/31689077
https://pubmed.ncbi.nlm.nih.gov/31689077
Publikováno v:
Cell Cycle. 7:830-832
Aberrant activation of the Wnt signal transduction pathway plays a pivotal role in the development of various human cancers, particularly those of the digestive tract. 1,2 A key component of this pathway is β-catenin, which drives the activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a623ba11585f4aaae2c8c185a06aeffd
https://doi.org/10.4161/cc.7.6.5614
https://doi.org/10.4161/cc.7.6.5614