Výsledky vyhledávání - "Delphine, Ravault"

Akademický článek

A cationic motif upstream Engrailed2 homeodomain controls cell internalization through selective interaction with heparan sulfates

Autor: Sébastien Cardon, Yadira P. Hervis, Gérard Bolbach, Chrystel Lopin-Bon, Jean-Claude Jacquinet, Françoise Illien, Astrid Walrant, Delphine Ravault, Bingwei He, Laura Molina, Fabienne Burlina, Olivier Lequin, Alain Joliot, Ludovic Carlier, Sandrine Sagan

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract Engrailed2 (En2) is a transcription factor that transfers from cell to cell through unconventional pathways. The poorly understood internalization mechanism of this cationic protein is proposed to require an initial interaction with cell-sur

Externí odkaz: https://doaj.org/article/c684e2cdb0ba43a69d9c0fdf51449845

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Akademický článek

Interaction of the Anti-Proliferative GPER Inverse Agonist ERα17p with the Breast Cancer Cell Plasma Membrane: From Biophysics to Biology

Autor: Michaël Trichet, Rosamaria Lappano, Mathilde Belnou, Lilian Shadai Salazar Vazquez, Isabel Alves, Delphine Ravault, Sandrine Sagan, Lucie Khemtemourian, Marcello Maggiolini, Yves Jacquot

Publikováno v: Cells, Vol 9, Iss 2, p 447 (2020)

The peptide ERα17p, which corresponds to the 295-311 fragment of the hinge/AF2 domains of the human estrogen receptor α (ERα), exerts apoptosis in breast cancer cells through a mechanism involving the G protein-coupled estrogen-dependent receptor

Externí odkaz: https://doaj.org/article/a6fc457b658e4d909016ddfd53836faf

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Structural Bases for the Involvement of Phosphatidylinositol-4,5-bisphosphate in the Internalization of the Cell-Penetrating Peptide Penetratin

Autor: Leïla Bechtella, Edward Chalouhi, Paula Milán Rodríguez, Marine Cosset, Delphine Ravault, Françoise Illien, Sandrine Sagan, Ludovic Carlier, Olivier Lequin, Patrick F. J. Fuchs, Emmanuelle Sachon, Astrid Walrant

Publikováno v: ACS Chemical Biology
ACS Chemical Biology, 2022, 17 (6), pp.1427-1439. ⟨10.1021/acschembio.1c00974⟩

International audience; Cell-penetrating peptides cross cell membranes through various parallel internalization pathways. Herein, we analyze the role of the negatively charged lipid phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) in the internaliza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d2682143fc8b0c6e59f0e9920049c8
https://pubmed.ncbi.nlm.nih.gov/35608167

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Conjugation of Oligo-His Peptides to Magnetic γ-Fe 2 O 3 @SiO 2 Core–Shell Nanoparticles Promotes Their Access to the Cytosol

Autor: Mathilde Le Jeune, Emilie Secret, Michaël Trichet, Aude Michel, Delphine Ravault, Françoise Illien, Jean-Michel Siaugue, Sandrine Sagan, Fabienne Burlina, Christine Ménager

Publikováno v: ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces, 2022, 14 (13), pp.15021-15034. ⟨10.1021/acsami.2c01346⟩

International audience; The endosomal entrapment of functional nanoparticles is a severe limitation to their use for biomedical applications. In the case of magnetic nanoparticles (MNPs), this entrapment leads to poor heating efficiency for magnetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3959679b7223bb64d11096e40211c3fe
https://hal.archives-ouvertes.fr/hal-03810702

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Drug Repurposing: Deferasirox Inhibits the Anti-Apoptotic Activity of Mcl-1

Autor: Asma Bourafai-Aziez, Mohammed Benabderrahmane, Hippolyte Paysant, Louis-Bastien Weiswald, Laurent Poulain, Ludovic Carlier, Delphine Ravault, Marie Jouanne, Gaël Coadou, Hassan Oulyadi, Anne-Sophie Voisin-Chiret, Jana Sopková-de Oliveira Santos, Muriel Sebban

Publikováno v: Drug Design, Development and Therapy

Introduction With the aim of repositioning commercially available drugs for the inhibition of the anti-apoptotic myeloid cell leukemia protein, Mcl-1, implied in various cancers, five molecules, highlighted from a published theoretical screening, wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032d7084420cebdb08117cf9b5d5850d
https://www.dovepress.com/drug-repurposing-deferasirox-inhibits-the-anti-apoptotic-activity-of-m-peer-reviewed-fulltext-article-DDDT

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Conjugation of oligo-His peptides to magnetic γ-Fe2O3@SiO2 core-shell nanoparticles promotes their access to the cytosol

Autor: Fabienne Burlina, Delphine Ravault, Aude Michel, Jean-Michel Siaugue, Emilie Secret, Michael Trichet, Mathilde Le Jeune, Christine Ménager, Sandrine Sagan, Françoise Illien

The endosomal entrapment of functional nanoparticles is a severe limitation to their use for biomedical applications. In the case of magnetic nanoparticles (MNPs), this entrapment leads to poor heating efficiency for magnetic hyperthermia and suppres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfaeb0b6b18c45e55c3e063788a5585
https://hal.archives-ouvertes.fr/hal-03450120

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A cationic motif in Engrailed-2 homeoprotein controls its internalization via selective cell-surface glycosaminoglycans interactions

Autor: Alain Joliot, Astrid Walrant, Françoise Illien, Sandrine Sagan, Olivier Lequin, Gérard Bolbach, Fabienne Burlina, Jean-Claude Jacquinet, Delphine Ravault, Laura Molina, Yadira P. Hervis, Bingwei He, Sébastien Cardon, Ludovic Carlier, Chrystel Lopin-Bon

Engrailed-2 (En2) is a transcription factor that possesses as most homeoproteins the unique and intriguing property to transfer from cell to cell through unconventional pathways. The internalization mechanism of this cationic protein is far from bein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52988369e5be299a35415f6ab50205d4
https://hal.archives-ouvertes.fr/hal-03429466

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Interaction of the Anti-Proliferative GPER Inverse Agonist ERα17p with the Breast Cancer Cell Plasma Membrane: From Biophysics to Biology

Autor: Delphine Ravault, Marcello Maggiolini, Lucie Khemtémourian, Isabel D. Alves, Sandrine Sagan, Mathilde Belnou, Michaël Trichet, Yves Jacquot, Lilian Shadai Salazar Vazquez, Rosamaria Lappano

Publikováno v: Cells
Cells, MDPI, 2020, 9 (2), pp.447. ⟨10.3390/cells9020447⟩
Cells, Vol 9, Iss 2, p 447 (2020)
Cells, 2020, 9 (2), pp.447. ⟨10.3390/cells9020447⟩
Volume 9
Issue 2

The peptide ER&alpha
17p, which corresponds to the 295-311 fragment of the hinge/AF2 domains of the human estrogen receptor &alpha
(ER&alpha
), exerts apoptosis in breast cancer cells through a mechanism involving the G protein-coupled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a9de9eb8203711b7ab708c85d381ad
https://hal.archives-ouvertes.fr/hal-03082948/document

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