LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA

Autor: Audrey Belot, Ophélie Gourbeyre, Alexis Fay, Anais Palin, Céline Besson-Fournier, Chloé Latour, Corey R. Hopkins, George F. Tidmarsh, Hélène Coppin, Marie-Paule Roth, Matthew R. Ritter, Charles C. Hong, Delphine Meynard

Publikováno v: Haematologica, Vol 105, Iss 8 (2020)

Externí odkaz: https://doaj.org/article/d555fb05493c42068ab26e253c257d45

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Autor: Anne Fougerat, Gabriele Schoiswohl, Arnaud Polizzi, Marion Régnier, Carina Wagner, Sarra Smati, Tiffany Fougeray, Yannick Lippi, Frederic Lasserre, Ilyès Raho, Valentine Melin, Blandine Tramunt, Raphaël Métivier, Caroline Sommer, Fadila Benhamed, Chantal Alkhoury, Franziska Greulich, Céline Jouffe, Anthony Emile, Michael Schupp, Pierre Gourdy, Patricia Dubot, Thierry Levade, Delphine Meynard, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Ganna Panasyuk, Henriette Uhlenhaut, Ez-Zoubir Amri, Céline Cruciani-Guglielmacci, Catherine Postic, Walter Wahli, Nicolas Loiseau, Alexandra Montagner, Dominique Langin, Achim Lass, Hervé Guillou

Publikováno v: Cell Reports
Cell Rep. 39:110910 (2022)
Cell Reports, Elsevier Inc, 2022, 39 (10), pp.110910. ⟨10.1016/j.celrep.2022.110910⟩
Cell Reports, 2022, 39 (10), ⟨10.1016/j.celrep.2022.110910⟩

International audience; In hepatocytes, peroxisome proliferator-activated receptor α (PPARα) orchestrates a genomic and metabolic response required for homeostasis during fasting. This includes the biosynthesis of ketone bodies and of fibroblast gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9037edac54186178b9379d38a6aa6ca9
https://doi.org/10.1016/j.celrep.2022.110910

Inflammation regulates TMPRSS6 expression via STAT5.

Autor: Delphine Meynard, Chia Chi Sun, Qifang Wu, Wenjie Chen, Shanzhuo Chen, Caroline N Nelson, Michael J Waters, Jodie L Babitt, Herbert Y Lin

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e82127 (2013)

TMPRSS6 is a regulated gene, with a crucial role in the regulation of iron homeostasis by inhibiting hepcidin expression. The main regulator of iron homeostasis, the antimicrobial peptide hepcidin, which also has a role in immunity, is directly upreg

Externí odkaz: https://doaj.org/article/a503fcf8a1664141b6682d180abba1dd

Regulators of hepcidin expression

Autor: Marie-Paule, Roth, Delphine, Meynard, Hélène, Coppin

Publikováno v: Vitamins and hormones. 110

Iron, an essential nutrient, is required for many biological processes but is also toxic in excess. The lack of a mechanism to excrete excess iron makes it crucial for the body to regulate the amount of iron absorbed from the diet. This regulation is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::712a99413669540d69123ee779188f64
https://pubmed.ncbi.nlm.nih.gov/30798807

Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge

Autor: Céline Besson-Fournier, Hélène Coppin, Marie-Paule Roth, Chloé Latour, Ophélie Gourbeyre, Delphine Meynard

Publikováno v: Blood
Blood, American Society of Hematology, 2017, 130 (21), pp.2339-2343. ⟨10.1182/blood-2017-07795658⟩

International audience; Lack of either bone morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) inmice leads to a similar phenotype with hepcidin insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6929cea6bd6121b46b9f4ca8a4c94e9
https://hal.inrae.fr/hal-02617586