Two functionally distinct heme/iron transport systems are virulence determinants of the fish pathogen Flavobacterium psychrophilum

Autor: Yueying Zhu, Delphine Lechardeur, Jean-François Bernardet, Brigitte Kerouault, Cyprien Guérin, Dimitri Rigaudeau, Pierre Nicolas, Eric Duchaud, Tatiana Rochat

Publikováno v: Virulence, Vol 13, Iss 1, Pp 1221-1241 (2022)

Bacterial pathogens have a critical impact on aquaculture, a sector that accounts for half of the human fish consumption. Flavobacterium psychrophilum (phylum Bacteroidetes) is responsible for bacterial cold-water disease in salmonids worldwide. The

Externí odkaz: https://doaj.org/article/795ed96466d9448187e7cc3e4abd46c6

HssS activation by membrane heme defines a paradigm for 2-component system signaling inStaphylococcus aureus

Autor: Vincent Saillant, Léo Morey, Damien Lipuma, Pierre Boëton, Pascal Arnoux, Delphine Lechardeur

Strict management of intracellular heme pools, which are both toxic and beneficial, can be crucial for bacterial survival during infection. The human pathogenStaphylococcus aureususes a two-component heme sensing system (HssRS), which counteracts env

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adb1064d6c8583a2cf23c7b2a1efce7e
https://doi.org/10.1101/2022.11.03.515132

Two coregulated efflux transporters modulate intracellular heme and protoporphyrin IX availability in Streptococcus agalactiae.

Autor: Annabelle Fernandez, Delphine Lechardeur, Aurélie Derré-Bobillot, Elisabeth Couvé, Philippe Gaudu, Alexandra Gruss

Publikováno v: PLoS Pathogens, Vol 6, Iss 4, p e1000860 (2010)

Streptococcus agalactiae is a major neonatal pathogen whose infectious route involves septicemia. This pathogen does not synthesize heme, but scavenges it from blood to activate a respiration metabolism, which increases bacterial cell density and is

Externí odkaz: https://doaj.org/article/b5c5622ce08e4f2a9c88c7e821d6a813

Genetics of Lactococci

Autor: Karin Hammer, Delphine Lechardeur, Peter Ruhdal Jensen, Yuji Yamamoto, Alexandra Gruss, Philippe Gaudu

Publikováno v: Gram-Positive Pathogens
Gaudu, P, Yamamoto, Y, Jensen, P R, Hammer, K, Lechardeur, D & Gruss, A 2019, ' Genetics of Lactococci ', Microbiology Spectrum, vol. 7, no. 4 . https://doi.org/10.1128/microbiolspec.GPP3-0035-2018
Microbiology Spectrum
Microbiology Spectrum, American Society for Microbiology, 2019, 7, ⟨10.1128/microbiolspec.gpp3-0035-2018⟩
Microbiology Spectrum, American Society for Microbiology, 2019, 7 (4), ⟨10.1128/microbiolspec.GPP3-0035-2018⟩

Lactococcus lactis is the best characterized species among the lactococci, and among the most consumed food-fermenting bacteria worldwide. Thanks to their importance in industrialized food production, lactococci are among the lead bacteria understood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dac9e6edef89ed5244cbd919ffb402
https://doi.org/10.1128/microbiolspec.gpp3-0035-2018

Respiration, a strategy to avoid oxidative stress in Lactococcus lactis, is regulated by the heme status

Autor: Philippe Gaudu, Gilles Lamberet, Annabelle Fernandez, Aurélie Derré-Bobillot, Bénédicte Cesselin, Yuji Yamamoto, Delphine Lechardeur, Martin Bastian Pedersen, Christel Garrigues

Publikováno v: Japanese Journal of Lactic Acid Bacteria. 21:10-15

Lactic acid bacteria (LAB) species like L. lactis are traditionally considered as obligate fermentative bacteria because even in aerobiosis they use sugar degradation for substrate-level phosphorylation, i.e. ATP production. However, recent studies r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46ed2c577f6e4da7fc09dd210dddc683
https://doi.org/10.4109/jslab.21.10