Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Delphine, Karila"'
Autor:
Millan Mark, Stephen Hanessian, Oscar Mario Saavedra, Jean-Claude Ortuno, Delphine Dupuis, Arnaud Gohier, Clotilde Mannoury la Cour, Anne Rojas, Dominique Brossard, Delphine Karila
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:38-52
All clinically-used antipsychotics display similar affinity for both D2 (D2R) and D3 (D3R) receptors, and they likewise act as 5-HT2A receptor antagonists. They provide therapeutic benefit for positive symptoms, but no marked or consistent improvemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b2e9933b4136694c252b0a9208bf634
https://doi.org/10.1016/j.bmc.2016.10.010
https://doi.org/10.1016/j.bmc.2016.10.010
Autor:
Julien, Lalut, Gianluca, Santoni, Delphine, Karila, Cédric, Lecoutey, Audrey, Davis, Florian, Nachon, Israel, Silman, Joel, Sussman, Martin, Weik, Tangui, Maurice, Patrick, Dallemagne, Christophe, Rochais
Publikováno v:
European journal of medicinal chemistry. 162
Pleiotropic intervention may be a requirement for effective limitation of the progression of multifactorial diseases such as Alzheimer's Disease. One approach to such intervention is to design a single chemical entity capable of acting on two or more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da41c78bdbe6e3e5ba602275c9738692
https://pubmed.ncbi.nlm.nih.gov/30447434
https://pubmed.ncbi.nlm.nih.gov/30447434
Autor:
Delphine Karila, Christophe Rochais, Patrick Dallemagne, Thomas Freret, Valentine Bouet, Michel Boulouard
Publikováno v:
Journal of Medicinal Chemistry. 58:7901-7912
Given its predominant expression in the central nervous system (CNS), 5-hydroxytryptamine (5-HT: serotonin) subtype 6 receptor (5-HT6R) has been considered as a valuable target for the development of CNS drugs with limited side effects. After 2 decad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d13eeb317da9ccaa213f7d80c25b33a1
https://doi.org/10.1021/acs.jmedchem.5b00179
https://doi.org/10.1021/acs.jmedchem.5b00179
Publikováno v:
Future Medicinal Chemistry
Future Medicinal Chemistry, Future Science, 2017, 9 (8), pp.781-795. ⟨10.4155/fmc-2017-0031⟩
Future Medicinal Chemistry, Future Science, 2017, 9 (8), pp.781-795. ⟨10.4155/fmc-2017-0031⟩
Alzheimer’s disease (AD) is the most common form of dementia affecting millions of patients worldwide which can only be treated with symptomatic drugs. Among the numbers of biological targets which are today explored in order to prevent or limit th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683507be4b1cbc2d0020ba2754b29ec9
https://hal.archives-ouvertes.fr/hal-02043735
https://hal.archives-ouvertes.fr/hal-02043735
Autor:
Oscar M, Saavedra, Delphine, Karila, Dominique, Brossard, Anne, Rojas, Delphine, Dupuis, Arnaud, Gohier, Clotilde, Mannoury la Cour, Mark J, Millan, Jean-Claude, Ortuno, Stephen, Hanessian
Publikováno v:
Bioorganicmedicinal chemistry. 25(1)
All clinically-used antipsychotics display similar affinity for both D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc6d50a83ec600d240520aa92647989d
https://pubmed.ncbi.nlm.nih.gov/28029458
https://pubmed.ncbi.nlm.nih.gov/28029458
Publikováno v:
ChemInform. 43
Five- and six-membered heterocycles such as tetrahydrofurans, tetrahydropyrans, cyclic carbamates are obtained with good yields from the starting styrene-derived 1-propanoates or butanoates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c09fd56b47872122bf35004c99bb3a0
https://doi.org/10.1002/chin.201212177
https://doi.org/10.1002/chin.201212177
Publikováno v:
Organic Letters
Organic Letters, American Chemical Society, 2011, 13 (21), pp.5830-3. ⟨10.1021/ol202436a⟩
Organic Letters, American Chemical Society, 2011, 13 (21), pp.5830-3. ⟨10.1021/ol202436a⟩
International audience; A copper(I)-catalyzed reaction of a variety of 4-aryl-pent-4-enoates with nosyliminoiodane generated in situ provides the corresponding 5-aryl-5-nosylamidomethylbutyrolactones. The reaction presumably proceeds via an aziridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ca24c586c2971ca2cc5d006498640e
https://hal.archives-ouvertes.fr/hal-00647702
https://hal.archives-ouvertes.fr/hal-00647702
Autor:
Robert H. Dodd, Delphine Karila
Publikováno v:
Current Organic Chemistry
Current Organic Chemistry, Bentham Science Publishers, 2011, 15 (10), pp.1507-1538. ⟨10.2174/138527211795378128⟩
Current Organic Chemistry, Bentham Science Publishers, 2011, 15 (10), pp.1507-1538. ⟨10.2174/138527211795378128⟩
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a012125b0d9347c446e8814dd0a3cee6
https://hal.archives-ouvertes.fr/hal-00671432
https://hal.archives-ouvertes.fr/hal-00671432
Publikováno v:
ChemInform. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c12826ebd94ffd4fb4b9b05e009f9
https://doi.org/10.1002/chin.201042202
https://doi.org/10.1002/chin.201042202
Publikováno v:
The Journal of organic chemistry. 75(12)
The application of a sequence involving a nitroso Diels-Alder cycloaddition and a ring-rearrangement metathesis to the total synthesis of (+/-)-8-epihalosaline and the formal synthesis of (+/-)-porantheridine is described. The formation of the 2,6-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e109015e13ec0a7bae56c4e353dc26
https://pubmed.ncbi.nlm.nih.gov/20504007
https://pubmed.ncbi.nlm.nih.gov/20504007