Výsledky vyhledávání - "Delphine, Courilleau"

Akademický článek

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

Autor: Candice Sartre, François Peurois, Marie Ley, Marie-Hélène Kryszke, Wenhua Zhang, Delphine Courilleau, Rodolphe Fischmeister, Yves Ambroise, Mahel Zeghouf, Sarah Cianferani, Yann Ferrandez, Jacqueline Cherfils

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current mo

Externí odkaz: https://doaj.org/article/2dfbc0bf1f07489eb3703f383bb0e99c

Zobrazit plný text záznamu

Akademický článek

Identification of Small Molecules Inhibiting Cardiomyocyte Necrosis and Apoptosis by Autophagy Induction and Metabolism Reprogramming

Autor: Dawei Liu, Félix Peyre, Yahir Alberto Loissell-Baltazar, Delphine Courilleau, Sandra Lacas-Gervais, Valérie Nicolas, Eric Jacquet, Svetlana Dokudovskaya, Frédéric Taran, Jean-Christophe Cintrat, Catherine Brenner

Publikováno v: Cells, Vol 11, Iss 3, p 474 (2022)

Improvement of anticancer treatments is associated with increased survival of cancer patients at risk of cardiac disease. Therefore, there is an urgent need for new therapeutic molecules capable of preventing acute and long-term cardiotoxicity. Here,

Externí odkaz: https://doaj.org/article/81e185c893984ddf9d0fd96e88019aa0

Zobrazit plný text záznamu

Plný text ve formátu HTML

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

Autor: Jacqueline Cherfils, Candice Sartre, Yann Ferrandez, François Peurois, Marie Ley, Wenhua Zhang, Marie-Hélène Kryszke, Delphine Courilleau, Rodolphe P. Fischmeister, Yves Ambroise, Mahel Zeghouf, Sarah Cianferani, Gérald Peyroche

EPAC1, a cAMP-activated GEF for Rap GTPases, is a major physiological transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63af2fa72d2ccb592ecb97d9a2deae34
https://doi.org/10.21203/rs.3.rs-2608569/v1

Zobrazit plný text záznamu

Identification of Small Molecules Inhibiting Cardiomyocyte Necrosis and Apoptosis by Autophagy Induction and Metabolism Reprogramming

Publikováno v: Cells, Vol 11, Iss 474, p 474 (2022)
Cells
Cells, 2022, 11 (3), pp.474. ⟨10.3390/cells11030474⟩
Cells; Volume 11; Issue 3; Pages: 474

International audience; Improvement of anticancer treatments is associated with increased survival of cancer patients at risk of cardiac disease. Therefore, there is an urgent need for new therapeutic molecules capable of preventing acute and long-te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015164e3267032eba8223595a21e13d6
https://pubmed.ncbi.nlm.nih.gov/35159285

Zobrazit plný text záznamu

Akademický článek

A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis.

Autor: Matthieu Ruiz, Delphine Courilleau, Jean-Christophe Jullian, Dominique Fortin, Renée Ventura-Clapier, Jean-Paul Blondeau, Anne Garnier

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46753 (2012)

Mitochondrial function is dramatically altered in heart failure (HF). This is associated with a decrease in the expression of the transcriptional coactivator PGC-1α, which plays a key role in the coordination of energy metabolism. Identification of

Externí odkaz: https://doaj.org/article/b4684032c8a14644aaf3a3da59e2ff79

Zobrazit plný text záznamu

A novel class of ethacrynic acid derivatives as promising drug-like potent generation of anticancer agents with established mechanism of action

Autor: Jean-Pierre Majoral, Mosto Bousmina, Anne-Marie Caminade, Laure Eloy, Thierry Cresteil, Joachim Caron, Saïd El Kazzouli, Delphine Courilleau, Nabil El Brahmi, Serge Mignani

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2016, 122, pp.656-673. ⟨10.1016/j.ejmech.2016.05.063⟩

International audience; The well-known diuretic Ethacrynic acid (EA, Edecrin), showing low anti-proliferative activities, was chemically modified at different positions. The new EA derivatives have been tested in vitro in anti-proliferative assays on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbc5b2bfcbc2295ec3c04cc3c390047
https://hal.archives-ouvertes.fr/hal-01933059

Zobrazit plný text záznamu

Hyaluronic acid-conjugated lipoplexes for targeted delivery of siRNA in a murine metastatic lung cancer model

Autor: Thais Leite Nascimento, Jung Soo Suk, Hervé Hillaireau, Melania Rivano, Claudine Deloménie, Silvia Arpicco, Delphine Courilleau, Juliette Vergnaud, Elias Fattal, Justin Hanes

We have investigated the impact of hyaluronic acid (HA)-coating on the targeting capacity of siRNA lipoplexes to CD44-overexpressing tumor cells. Cellular uptake and localization of HA-lipoplexes were evaluated by flow cytometry and fluorescence micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4725d8cc83e167674a845285aeef4e27
http://hdl.handle.net/2318/1615996

Zobrazit plný text záznamu

OPA1 (dys)functions

Autor: Ambre M. Bertholet, Delphine Courilleau, Laetitia Arnauné-Pelloquin, Pascale Belenguer, Aurélien Olichon, Noélie Davezac, Laurent J. Emorine, Ingrid Leroy, Guy Lenaers, Thomas Landes, Emmanuelle Guillou, Alan Diot, Marie-Christine Miquel, Farnoosh Khosrobakhsh, Marlène Daloyau

Publikováno v: Seminars in Cell & Developmental Biology. 21:593-598

Mitochondrial morphology varies according to cell type and cellular context from an interconnected filamentous network to isolated dots. This morphological plasticity depends on mitochondrial dynamics, a balance between antagonistic forces of fission

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d2cdc7edf5ca12a344e3d7d1589a35
https://doi.org/10.1016/j.semcdb.2009.12.012

Zobrazit plný text záznamu

Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas

Autor: D D Billadeau, Damien Ramel, Frédérique Gaits-Iacovoni, Bernard Payrastre, Georges Delsol, E Espinos, Delphine Courilleau, A Colomba

Publikováno v: Oncogene. 27:2728-2736

The majority of anaplastic large cell lymphomas (ALCLs) express the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion protein, which is oncogenic due to its constitutive tyrosine kinase activity. Transformation by NPM-ALK not only increases p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9217bcd969a4deaf37cd5511587b9b16
https://doi.org/10.1038/sj.onc.1210921

Zobrazit plný text záznamu

Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1

Autor: Gaëtan Chicanne, Sophie Allart, Olivier Pertz, Damien Ramel, Bernard Payrastre, Frédérique Gaits-Iacovoni, Julien Viaud, Jean-Marie Xuereb, Laurie Ceccato, Delphine Courilleau, Frederic Lagarrigue

Publikováno v: Nature Communications. 5

PtdIns5P is a lipid messenger acting as a stress-response mediator in the nucleus, and known to maintain cell activation through traffic alterations upon bacterial infection. Here, we show that PtdIns5P regulates actin dynamics and invasion via recru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc7672ba89aa77cf03d989212212690
https://doi.org/10.1038/ncomms5080

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání