Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Delphine, Allard"'
Autor:
Nicolas J. Tourasse, Armelle Choquet, Dominique Joubert, Delphine Allard, Tom Lesluyes, Hélène Dumay-Odelot, Stéphanie Durrieu-Gaillard, Galina Boldina, Jean-William Dupuy, Pauline Lagarde, Robert G. Roeder, Guillaume Drutel, Stéphan Vagner, Marion Petitet, Frédéric Chibon, Françoise Macari, Martin Teichmann, Thierry Leste-Lasserre, Lydia Lartigue-Faustin, Fabrice Andre
Publikováno v:
Cell Cycle. 17:605-615
RNA polymerase (Pol) III transcribes small untranslated RNAs that are essential for cellular homeostasis and growth. Its activity is regulated by inactivation of tumor suppressor proteins and overexpression of the oncogene c-MYC, but the concerted ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9bac8423d42c68122da4d327b67bed2
https://doi.org/10.1080/15384101.2017.1405881
https://doi.org/10.1080/15384101.2017.1405881
Autor:
Alain Eychène, Laurent Désaubry, Michael Cerezo, Alexander M.M. Eggermont, Jean-Yves Scoazec, Stéphan Vagner, Nahum Sonenberg, Isabelle Girault, Sandrine Agoussi, Sylvain Martineau, Julien Adam, C. Libenciuc, Shensi Shen, Emilie Routier, Ramdane Guemiri, Charlène Estrada, Hélène Malka-Mahieu, Caroline Robert, Séverine Roy, Delphine Allard, Sabine Druillennec, Caroline Welsch
Publikováno v:
Nature Medicine
Nature Medicine, Nature Publishing Group, 2018, 24 (12), pp.1877-1886. ⟨10.1038/s41591-018-0217-1⟩
Nature Medicine, Nature Publishing Group, 2018, 24 (12), pp.1877-1886. ⟨10.1038/s41591-018-0217-1⟩
Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) receptor, is a powerful anticancer approach. However, many patients do not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039d463fbad4ea430ad9a3a156b2c13b
https://pubmed.ncbi.nlm.nih.gov/30451955
https://pubmed.ncbi.nlm.nih.gov/30451955
Autor:
Stéphan Vagner, C. Libenciuc, D. Darbord, Caroline Robert, Delphine Allard, Virginie Quidville, Isabelle Girault, Shensi Shen, Emilie Routier, Sandrine Agoussi, R. Guemiri, Séverine Roy, Michael Cerezo, A. Moya-Plana, G. Claps
Publikováno v:
Annales de Dermatologie et de Vénéréologie. 145:S101
Introduction Des progres majeurs ont recemment ete realises dans le traitement du melanome grâce aux immunotherapies ciblant l’axe PD1/PDL1. Dans le melanome, l’expression de PDL1 est essentiellement induite par l’interferon gamma secrete par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7763f79e8615935cb540cf56c4615b4
https://doi.org/10.1016/j.annder.2018.09.098
https://doi.org/10.1016/j.annder.2018.09.098
Autor:
Jean-Jacques Grob, Ana Maria Arance Fernandez, Egbert de Jong, Delphine Allard, Caroline Dutriaux, Caroline Robert, Matthew Squires, Shensi Shen
Publikováno v:
Cancer Research. 78:CT087-CT087
Several trials are evaluating combinations of BRAFi/MEKi and immunotherapy (IO) treatment (Tx) in melanoma. This descriptive biomarker study explored tumor cell and TME modification during BRAFi, MEKi or combination Tx in pts with BRAF V600E/K–muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79fbe231045596e2a4fa9ddf1f9b6e1f
https://doi.org/10.1158/1538-7445.am2018-ct087
https://doi.org/10.1158/1538-7445.am2018-ct087
Publikováno v:
Current Genomics. 6:535-543
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f78c3efc2f9df13de411b8bbb5b06b77
https://doi.org/10.2174/138920205775067729
https://doi.org/10.2174/138920205775067729
Autor:
Angie Tebon, Delphine Allard, Marie-Claude Asselin, Louise Wickham, Marianne Abifadel, Suzanne Benjannet, Nabil G. Seidah, Michel Chrétien, Louise Brissette, Josée Hamelin, Alan D. Attie, Daniel J. Rader, Janice Mayne, Rachid Essalmani, Annik Prat, Weijun Jin, Mélanie Trillard, David Rhainds, Catherine Boileau, Mathilde Varret
Publikováno v:
Journal of Biological Chemistry. 279:48865-48875
The discovery of autosomal dominant hypercholesterolemic patients with mutations in the PCSK9 gene, encoding the proprotein convertase NARC-1, resulting in the missense mutations suggested a role in low density lipoprotein (LDL) metabolism. We show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::942e4ee47923fe5f50e2facb8efa8367
https://doi.org/10.1074/jbc.m409699200
https://doi.org/10.1074/jbc.m409699200
Autor:
Stéphan Vagner, Alexander M.M. Eggermont, Isabelle Girault, Gorana Tomasic, Oskar Hemmingsson, Christina Mateus, Nyam Kamsu-Kom, M. Thomas, Sandrine Agoussi, Nigel Ribeiro, Christine Basmadjian, Frédéric Thuaud, Emilie Routier, Hélène Malka-Mahieu, Caroline Robert, Laurent Désaubry, Lise Boussemart, Delphine Allard
Publikováno v:
Nature. 513(7516)
In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signal transduction pathway, on activation of the alterna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ba96fb87a88ec00855a6e24b38f312
https://pubmed.ncbi.nlm.nih.gov/25220342
https://pubmed.ncbi.nlm.nih.gov/25220342
Autor:
Eric Bruckert, Michel Farnier, Isabel Beucler, Louise Wickham, Delphine Allard, Mathilde Varret, Khadija Ouguerram, Bernard Chanu, Annick Prat, Corinne Cruaud, Martine Devillers, Ludovic Villéger, Jean-Pierre Rabès, Jean Chambaz, Aurélie Derré, Gérald Luc, D. Erlich, Jean Weissenbach, Nabil G. Seidah, Michel Krempf, Suzanne Benjannet, Marianne Abifadel, Jean-Michel Lecerf, Claudine Junien, Philippe Moulin, Catherine Boileau
Publikováno v:
Nature Genetics. 34:154-156
Autosomal dominant hypercholesterolemia (ADH; OMIM144400), a risk factor for coronary heart disease, is characterized by an increase in low-density lipoprotein cholesterol levels that is associated with mutations in the genes LDLR (encoding low-densi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f0acf39d1cdeed843e7c3de2d3a496c
https://doi.org/10.1038/ng1161
https://doi.org/10.1038/ng1161
Autor:
Isabelle Girault, Sandrine Agoussi, Nyam Kamsu-Kom, Hélène Malka-Mahieu, Laurent Désaubry, Caroline Robert, Delphine Allard, Oskar Hemmingson, Lise Boussemart, Alexander M.M. Eggermont, Stéphan Vagner
Publikováno v:
Clinical Cancer Research. 21:A23-A23
The V600E mutation in BRAF is the most frequent oncogenic mutation in human cancers, and can be targeted by specific anti-BRAF agents. However, several mechanisms of resistance have been identified, leading to reactivation of the initially blocked MA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2adf3e2e9521b63804a68000a0005a6
https://doi.org/10.1158/1557-3265.pms14-a23
https://doi.org/10.1158/1557-3265.pms14-a23
Autor:
Suzanne, Benjannet, David, Rhainds, Rachid, Essalmani, Janice, Mayne, Louise, Wickham, Weijun, Jin, Marie-Claude, Asselin, Josée, Hamelin, Mathilde, Varret, Delphine, Allard, Mélanie, Trillard, Marianne, Abifadel, Angie, Tebon, Alan D, Attie, Daniel J, Rader, Catherine, Boileau, Louise, Brissette, Michel, Chrétien, Annik, Prat, Nabil G, Seidah
Publikováno v:
The Journal of biological chemistry. 279(47)
The discovery of autosomal dominant hypercholesterolemic patients with mutations in the PCSK9 gene, encoding the proprotein convertase NARC-1, resulting in the missense mutations suggested a role in low density lipoprotein (LDL) metabolism. We show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f4973af9ce4789418a6c3bb5f85660c
https://pubmed.ncbi.nlm.nih.gov/15358785
https://pubmed.ncbi.nlm.nih.gov/15358785