Racial disparities in liver cancer: Evidence for a role of environmental contaminants and the epigenome

Autor: Adriana C. Vidal, Cynthia A. Moylan, Julius Wilder, Delores J. Grant, Susan K. Murphy, Cathrine Hoyo

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Liver cancer incidence has tripled since the early 1980s, making this disease one of the fastest rising types of cancer and the third leading cause of cancer-related deaths worldwide. In the US, incidence varies by geographic location and race, with

Externí odkaz: https://doaj.org/article/3febe2a8078841bf8af65ef6d144307e

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women

Autor: Delores J. Grant, Ani Manichaikul, Anthony J. Alberg, Elisa V. Bandera, Jill Barnholtz‐Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, Patricia G. Moorman, Lauren C. Peres, Edward S. Peters, Ann G. Schwartz, Paul D. Terry, Xin‐Qun Wang, Temitope O. Keku, Cathrine Hoyo, Andrew Berchuck, Dale P. Sandler, Jack A. Taylor, Katie M. O’Brien, Digna R. Velez Edwards, Todd L. Edwards, Alicia Beeghly‐Fadiel, Nicolas Wentzensen, Celeste Leigh Pearce, Anna H. Wu, Alice S. Whittemore, Valerie McGuire, Weiva Sieh, Joseph H. Rothstein, Francesmary Modugno, Roberta Ness, Kirsten Moysich, Mary Anne Rossing, Jennifer A. Doherty, Thomas A. Sellers, Jennifer B. Permuth‐Way, Alvaro N. Monteiro, Douglas A. Levine, Veronica Wendy Setiawan, Christopher A. Haiman, Loic LeMarchand, Lynne R. Wilkens, Beth Y. Karlan, Usha Menon, Susan Ramus, Simon Gayther, Aleksandra Gentry‐Maharaj, Kathryn L. Terry, Daniel W. Cramer, Ellen L. Goode, Melissa C. Larson, Scott H. Kaufmann, Rikki Cannioto, Kunle Odunsi, John L. Etter, Ruea‐Yea Huang, Marcus Q. Bernardini, Alicia A. Tone, Taymaa May, Marc T. Goodman, Pamela J. Thompson, Michael E. Carney, Shelley S. Tworoger, Elizabeth M. Poole, Diether Lambrechts, Ignace Vergote, Adriaan Vanderstichele, Els Van Nieuwenhuysen, Hoda Anton‐Culver, Argyrios Ziogas, James D. Brenton, Line Bjorge, Helga B. Salvensen, Lambertus A. Kiemeney, Leon F. A. G. Massuger, Tanja Pejovic, Amanda Bruegl, Melissa Moffitt, Linda Cook, Nhu D. Le, Angela Brooks‐Wilson, Linda E. Kelemen, Paul D.P. Pharoah, Honglin Song, Ian Campbell, Diana Eccles, Anna DeFazio, Catherine J. Kennedy, Joellen M. Schildkraut

Publikováno v: Cancer Medicine, Vol 8, Iss 5, Pp 2503-2513 (2019)

Abstract An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and

Externí odkaz: https://doaj.org/article/e1138d0ca72749ca892bbfadf3342940

UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression

Autor: Delores J. Grant, Zinan Chen, Lauren E. Howard, Emily Wiggins, Amanda De Hoedt, Adriana C. Vidal, Skyla T. Carney, Jill Squires, Clara E. Magyar, Jiaoti Huang, Stephen J. Freedland

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017)

Abstract Background Uridine 5′-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expressio

Externí odkaz: https://doaj.org/article/5419a6935b584351a2cc57bda30313c7

Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells

Autor: Cathrine Hoyo, Delores J Grant, Farideh Shafiee-Kermani, Dereje D. Jima, H. Karimi Kinyamu, Stephen J. Freedland, Beverly H. Koller, Kevin W. Trotter, LaNeisha B Farrar, Trevor K. Archer, Marcono R Hines, Skyla T. Carney, Melvin O Oputa, Utibe C Utin

Publikováno v: Epigenetics. 16:289-299

Studies have suggested that abrogated expression of detoxification enzymes, UGT2B15 and UGT2B17, are associated with prostate tumour risk and progression. We investigated the role of EGF on the expression of these enzymes since it interacts with sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2be236e08ecc5e5e93a9ceaa4adee09
https://doi.org/10.1080/15592294.2020.1795601

Expression of UDP Glucuronosyltransferases

Autor: Farideh, Shafiee-Kermani, Skyla T, Carney, Dereje, Jima, Utibe C, Utin, LaNeisha B, Farrar, Melvin O, Oputa, Marcono R, Hines, H Karimi, Kinyamu, Kevin W, Trotter, Trevor K, Archer, Cathrine, Hoyo, Beverly H, Koller, Stephen J, Freedland, Delores J, Grant

Publikováno v: Epigenetics

Studies have suggested that abrogated expression of detoxification enzymes, UGT2B15 and UGT2B17, are associated with prostate tumour risk and progression. We investigated the role of EGF on the expression of these enzymes since it interacts with sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b40648967ea5831e85c4348df6523974
https://pubmed.ncbi.nlm.nih.gov/32660355