Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Delon W. Barfuss"'
Autor:
Aditi Dave, Lucy Joshee, Delon W. Barfuss, Ryan Brownlee, Roha Surani, Sahar Anis Ali, Earl G. Ford IV, Elizabeth G. Pittman, Anasalea V.G. Caroland, Jennifer Barkin, Christy C. Bridges
Publikováno v:
Current Research in Toxicology, Vol 5, Iss , Pp 100132- (2023)
Mercury (Hg) is an important environmental toxicant to which humans are exposed on a regular basis. Mercuric ions within biological systems do not exist as free ions. Rather, they are bound to free sulfhydryl groups (thiols) on biological molecules.
Externí odkaz:
https://doaj.org/article/fbbe915c408f4a8e8069484f665e44f8
Autor:
Delon W. Barfuss, John T. Buchanan, Lucy Joshee, Elizabeth H. Pittman, Nigel D'Souza, Kayla E. Matta, Ryan T. Brownlee, Christy C. Bridges
Publikováno v:
Toxicology letters. 359
Mercury (Hg) is a toxic heavy metal to which humans are exposed on a regular basis. Hg has a high affinity for thiol-containing biomolecules with the majority of Hg in blood being bound to albumin. The current study tested the hypothesis that circula
Publikováno v:
Toxicological Sciences. 154:278-288
Chronic kidney disease is characterized by a progressive and permanent loss of functioning nephrons. In order to compensate for this loss, the remaining functional nephrons undergo significant structural and functional changes. We hypothesize that lu
Autor:
Rudolfs K. Zalups, Delon W. Barfuss
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 65:1471-1490
This study was designed to evaluate the effects of simultaneous coexposure to inorganic mercury and cadmium on the renal and hepatic disposition of each metal. Dispositional changes were assessed in rats 1 h and 24 h after the coexposure to relativel
Autor:
Rudolfs K. Zalups, Delon W. Barfuss
Publikováno v:
Toxicology and Applied Pharmacology. 182:234-243
The basolateral handling of 20 microM inorganic mercury (Hg(2+)), in the form of mercuric conjugates of cysteine (Cys), N-acetylcysteine (NAC), or glutathione (GSH), was studied in isolated perfused S2 segments of the rabbit proximal tubule. One of t
Publikováno v:
Journal of the American Society of Nephrology. 11:394-402
The aim of this study was to define mechanisms involved in the luminal uptake of inorganic mercury in the kidney using isolated perfused straight (S 2 ) segments of the proximal tubule. When mercuric conjugates of glutathione (GSH), cysteinylglycine,
Publikováno v:
Chemico-Biological Interactions. 123:171-195
Influences of biliary ligation and systemic depletion of glutathione (GSH) or modulation of GSH status on the disposition of a low, non-nephrotoxic i.v. dose of inorganic mercury were evaluated in rats in the present study. Renal and hepatic disposit
Publikováno v:
American Journal of Physiology-Renal Physiology. 274:F924-F931
This study was designed to examine the synthesis and possible secretion of glutathione (GSH) in the S1, S2, and S3segments of the rabbit proximal tubule. GSH synthesis and secretion rates were measured in the three segments of the proximal tubule, us
Autor:
Delon W. Barfuss, Rudolfs K. Zalups
Publikováno v:
Journal of the American Society of Nephrology. 9:551-561
Mechanisms involved in the renal uptake of inorganic mercury were studied in rats administered a nontoxic 0.5 mumol/kg intravenous dose of inorganic mercury with or without 2.0 mumol/kg cysteine, homocysteine, or N-acetylcysteine. The renal dispositi
Autor:
Delon W. Barfuss, Rudolfs K. Zalups
Publikováno v:
Toxicology. 109:15-29
In the present study, we tested the hypothesis that co-administration of low nephrotoxic doses of inorganic mercury (Hg ++ ) with l -cysteine (in a 1:2 mol ratio of inorganic mercury to l -cysteine), alters significantly the nephropathy induced by in