Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Delmis E. Hernandez"'
Autor:
Delmis E. Hernandez, Herman O. Sintim
Publikováno v:
ACS Central Science, Vol 6, Iss 2, Pp 93-96 (2020)
Externí odkaz:
https://doaj.org/article/a7cd8b78ef7641dc8b8ebb2258bd8e8c
Autor:
Haresh Ajani, Miroslav Peřina, Radek Jorda, Delmis E. Hernandez, Pavlína Řezáčová, Stefan Djukic, Neetu Dayal, Martin Lepšík, Eva Řezníčková, Veronika Vojáčková, Jana Škerlová, Sandra E. Torregrosa-Allen, Bennett D. Elzey, Vladimír Kryštof, Herman O. Sintim
Publikováno v:
Journal of Medicinal Chemistry. 64:10981-10996
The 3H-pyrazolo[4,3-f]quinoline moiety has been recently shown to be a privileged kinase inhibitor core with potent activities against acute myeloid leukemia (AML) cell lines in vitro. Herein, various 3H-pyrazolo[4,3-f]quinoline-containing compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c40f35a27294ccda9206f652f5548d75
https://doi.org/10.1021/acs.jmedchem.1c00330
https://doi.org/10.1021/acs.jmedchem.1c00330
Autor:
Herman O. Sintim, Neetu Dayal, Brandon Carter-Cooper, George A Naclerio, Delmis E. Hernandez, Clinton G. Mikek, Rena G. Lapidus, Elizabeth Fei Yin Chu
Publikováno v:
European Journal of Medicinal Chemistry. 180:449-456
Rho-associated protein kinases (ROCKs) are ubiquitously expressed in most adult tissues, and are involved in modulating the cytoskeleton, protein synthesis and degradation pathways, synaptic function, and autophagy to list a few. A few ROCK inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed90d843ed2f78a2ed8048ae571b784
https://doi.org/10.1016/j.ejmech.2019.06.089
https://doi.org/10.1016/j.ejmech.2019.06.089
Inhibitors of Intracellular Gram-Positive Bacterial Growth Synthesized via Povarov–Doebner Reactions
Autor:
Nader S. Abutaleb, Haroon Mohammad, Neetu Dayal, Herman O. Sintim, Kenneth I. Onyedibe, Matthias Zeller, Mohamed N. Seleem, Modi Wang, Clement Opoku-Temeng, Delmis E. Hernandez
Publikováno v:
ACS Infectious Diseases. 5:1820-1830
Staphylococcus aureus can survive both inside and outside of phagocytic and nonphagocytic host cells. Once in the intracellular milieu, most antibiotics have reduced ability to kill S. aureus, thus...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b153396b6c3acd8a0c84fbfc96a11c68
https://doi.org/10.1021/acsinfecdis.9b00022
https://doi.org/10.1021/acsinfecdis.9b00022
Publikováno v:
Chemical communications (Cambridge, England). 54(36)
Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the tetrahydro-3H-pyrazolo[4,3-a]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51e265189c156f2b687948f9a08aead
https://pubmed.ncbi.nlm.nih.gov/29629444
https://pubmed.ncbi.nlm.nih.gov/29629444
Autor:
Herman O. Sintim, Moloud Aflaki Sooreshjani, Brandon Carter-Cooper, Neetu Dayal, Clement Opoku-Temeng, Delmis E. Hernandez, Rena G. Lapidus
Publikováno v:
Future Medicinal Chemistry
Aim: Approximately 30% of acute myeloid leukemia (AML) patients carry FLT3 tyrosine kinase domain (TKD) mutations or internal tandem duplication (FLT3-ITD). Currently there is a paucity of compounds that are active against drug-resistant FLT3-ITD, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62b95296f8a75dd7919136606e5c9c6
https://pubmed.ncbi.nlm.nih.gov/29437468
https://pubmed.ncbi.nlm.nih.gov/29437468
Dissertation/ Thesis
Using a version of the Povarov-Doebner reaction, we were able to identify and develop a novel kinase inhibitor scaffold that is tunable, selective, and able to target drug-resistant mutant kinases. The 3H-pyrazolo[4,3-f]quinoline moiety was shown to
