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Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.

Autor: Hoang TN; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Boddapati AK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Viox EG; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Starke CE; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA., Upadhyay AA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Gumber S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Busman-Sahay K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA., Strongin Z; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Tharp GK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Pellegrini KL; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Kirejczyk S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Zandi K; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA., Tao S; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA., Horton TR; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Beagle EN; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Mahar EA; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Lee MY; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Cohen J; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Jean SM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Wood JS; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Stammen RL; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Delmas OM; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Wang S; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Cooney KA; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA., Sayegh MN; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA., Wang L; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA., Filev PD; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, Georgia, USA., Waggoner J; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA., Piantadosi A; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA., Kasturi SP; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Al-Shakhshir H; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., Ribeiro SP; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., Sekaly RP; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., Levit RD; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA., Estes JD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA., Vanderford TH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Schinazi RF; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA., Bosinger SE; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA., Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Sep 16. Date of Electronic Publication: 2020 Sep 16.