Salvage therapy expands highly cytotoxic and metabolically fit resilient CD8 ⁺ T cells via ME1 up-regulation.

Autor: Gicobi JK; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Mao Z; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., DeFranco G; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Hirdler JB; Department of Urology, Mayo Clinic, Rochester, MN, USA., Li Y; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA., Vianzon VV; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Dellacecca ER; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Hsu MA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Barham W; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Yan Y; Division of Medical Oncology, Mayo Clinic, Jacksonville, FL, USA., Mansfield AS; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Lin Y; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Wu X; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Hitosugi T; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Owen D; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Grams MP; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Orme JJ; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Lucien F; Department of Urology, Mayo Clinic, Rochester, MN, USA., Zeng H; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Rheumatology, Mayo Clinic, Rochester, MN, USA., Park SS; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Dong H; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Urology, Mayo Clinic, Rochester, MN, USA.

Publikováno v: Science advances [Sci Adv] 2023 Nov 17; Vol. 9 (46), pp. eadi2414. Date of Electronic Publication: 2023 Nov 15.

Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice.

Autor: Thomas A; Department of Dermatology, Feinberg School of Medicine.; Robert H. Lurie Comprehensive Cancer Center., Sumughan S; Robert H. Lurie Comprehensive Cancer Center., Dellacecca ER; Robert H. Lurie Comprehensive Cancer Center., Shivde RS; Robert H. Lurie Comprehensive Cancer Center., Lancki N; Quantitative Data Sciences Core, Robert H. Lurie Comprehensive Cancer Center; and., Mukhatayev Z; Robert H. Lurie Comprehensive Cancer Center., Vaca CC; Robert H. Lurie Comprehensive Cancer Center., Han F; Department of Dermatology, Feinberg School of Medicine.; Robert H. Lurie Comprehensive Cancer Center., Barse L; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Henning SW; Robert H. Lurie Comprehensive Cancer Center., Zamora-Pineda J; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University, Maywood, Illinois, USA., Akhtar S; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University, Maywood, Illinois, USA., Gupta N; Robert H. Lurie Comprehensive Cancer Center.; Illinois Mathematics and Science Academy, Aurora, Illinois, USA., Zahid JO; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University, Maywood, Illinois, USA., Zack SR; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University, Maywood, Illinois, USA., Ramesh P; Robert H. Lurie Comprehensive Cancer Center., Jaishankar D; Robert H. Lurie Comprehensive Cancer Center., Lo AS; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Moss J; Pulmonary Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA., Picken MM; Department of Pathology, Loyola University, Maywood, Illinois, USA., Darling TN; Department of Dermatology, School of Medicine, Uniformed Services University, Bethesda, Maryland, USA., Scholtens DM; Quantitative Data Sciences Core, Robert H. Lurie Comprehensive Cancer Center; and.; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Dilling DF; Department of Medicine, Stritch School of Medicine, Loyola University, Maywood, Illinois, USA., Junghans RP; Department of Hematology/Oncology, School of Medicine, Boston University, Boston, Massachusetts, USA., Le Poole IC; Department of Dermatology, Feinberg School of Medicine.; Robert H. Lurie Comprehensive Cancer Center.; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Publikováno v: JCI insight [JCI Insight] 2021 Nov 22; Vol. 6 (22). Date of Electronic Publication: 2021 Nov 22.

Antigen Specificity Enhances Disease Control by Tregs in Vitiligo.

Autor: Mukhatayev Z; Department of Dermatology, Northwestern University, Chicago, IL, United States.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United States.; Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.; Laboratory of Molecular immunology and Immunobiotechnology, M.A. Aitkhozhin's Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan., Dellacecca ER; Department of Dermatology, Northwestern University, Chicago, IL, United States.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United States., Cosgrove C; Department of Dermatology, Northwestern University, Chicago, IL, United States.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United States., Shivde R; Department of Dermatology, Northwestern University, Chicago, IL, United States.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United States., Jaishankar D; Department of Dermatology, Northwestern University, Chicago, IL, United States.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United States., Pontarolo-Maag K; Oncology Research Institute, Loyola University, Maywood, IL, United States., Eby JM; Oncology Research Institute, Loyola University, Maywood, IL, United States., Henning SW; Oncology Research Institute, Loyola University, Maywood, IL, United States., Ostapchuk YO; Laboratory of Molecular immunology and Immunobiotechnology, M.A. Aitkhozhin's Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan., Cedercreutz K; Department of Dermatology, Northwestern University, Chicago, IL, United States., Issanov A; Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan., Mehrotra S; Department of Surgery, Medical University of South Carolina, Charleston, SC, United States., Overbeck A; Department for Surgery of Pigment Disorders, Lumiderm, Madrid, Spain., Junghans RP; Department of Hematology/Oncology, Boston University, Boston MA, United States., Leventhal JR; Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL, United States., Le Poole IC; Department of Dermatology, Northwestern University, Chicago, IL, United States.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Dec 01; Vol. 11, pp. 581433. Date of Electronic Publication: 2020 Dec 01 (Print Publication: 2020).

Antibiotics Drive Microbial Imbalance and Vitiligo Development in Mice.

Autor: Dellacecca ER; Oncology Research Institute, Loyola University, Chicago, Illinois, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA; Department of Dermatology, Northwestern University, Chicago, Illinois, USA., Cosgrove C; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA; Department of Dermatology, Northwestern University, Chicago, Illinois, USA., Mukhatayev Z; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA; Department of Dermatology, Northwestern University, Chicago, Illinois, USA; Department of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan., Akhtar S; Oncology Research Institute, Loyola University, Chicago, Illinois, USA; Department of Surgery, Loyola University, Chicago, Illinois, USA., Engelhard VH; Carter Immunology Center and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA., Rademaker AW; Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA., Knight KL; Department of Microbiology and Immunology, Loyola University, Chicago,Illinois, USA., Le Poole IC; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA; Department of Dermatology, Northwestern University, Chicago, Illinois, USA; Department of Microbiology and Immunology, Northwestern University, Chicago, Illinois, USA. Electronic address: caroline.lepoole@northwestern.edu.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2020 Mar; Vol. 140 (3), pp. 676-687.e6. Date of Electronic Publication: 2019 Aug 28.

Transgenerational transfer of gene-modified T cells.

Autor: Cosgrove C; Department of Dermatology/ Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA., Dellacecca ER; Department of Dermatology/ Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA., van den Berg JH; Division of Molecular Oncology & Immunology/ Netherlands Cancer Institute, Amsterdam, Netherlands., Haanen JB; Division of Molecular Oncology & Immunology/ Netherlands Cancer Institute, Amsterdam, Netherlands., Nishimura MI; Department of Surgery, Loyola University Chicago, Maywood, IL, USA., Le Poole IC; Departments of Dermatology, Microbiology and Immunology, Northwestern University at Chicago, Lurie Comprehensive Cancer Center, Rm 3-121, 303 East Superior Street, Chicago, IL, 60611, USA. caroline.lepoole@northwestern.edu., Bergmans HEN; National Institute for Health and the Environment (RIVM), Bilthoven, Netherlands.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2019 Jul 15; Vol. 7 (1), pp. 186. Date of Electronic Publication: 2019 Jul 15.