Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Della White"'
Autor:
Della White, Alexandra Cote-Martin, Marina Bleck, Nicole Garaffa, Abdulsalam Shaaban, Helen Wu, Dongmei Liu, David Young, Justin Scheer, Ivo C. Lorenz, Andrew Nixon, Jay S. Fine, Fergus R. Byrne, M.Lamine Mbow, Miguel E. Moreno-Garcia
Publikováno v:
Molecular Immunology. 156:31-38
Autor:
Monica Patel, Mita Patel, Thomas Wai-Ho Lee, John Lord, Brian Christopher Raudenbush, Heather Grbic, Hossein Razavi, Darren Disalvo, David Joseph, Maryanne L. Brown, Alan David Swinamer, Della White, Siqi Lin, Karen Berg, Alison Kukulka, David S. Thomson, Christopher Ronald Sarko, Kim Fletcher, Pingrong Liu, Can Mao, Laura Amodeo, Christian Harcken
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(3)
A HTS screen for CCR1 antagonists afforded a novel sub-micromolar hit 5 containing a pyrazole core. In this report the design, optimization, and SAR of novel CCR1 antagonists based on a pyrazole core motif is presented. Optimization led to the advanc
Autor:
Mary Sanville-Ross, Melissa Canfield, Gerhard Schaenzle, Bernd Guilliard, Eva Wex, Daniel Bischoff, Sylvia Blum, Don Souza, Andreas Schnapp, Mark Panzenbeck, Mohammed A. Kashem, Helena Obernolte, Oliver Radmacher, Della White, Georg Rast, Gerd-Michael Maier, Jennifer L Swantek, Olga Danov, Stefan lutz Wollin, Hannah Haas, Christine Strasser, Armin Braun, Katherina Sewald, Thierry Bouyssou, Klaus J. Erb, Takeshi Kono, Eva Thaler, Helga Nickel, Matthias Hoffmann, David J. Lamb
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 357(3)
BI 1002494 [(R)-4-{(R)-1-[7-(3,4,5-trimethoxy-phenyl)-[1,6]napthyridin-5-yloxy]-ethyl}pyrrolidin-2-one] is a novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with sustained plasma exposure after oral administration in rats, which q
Autor:
Kathy Crane, Michel J. Emmanuel, Younes Bekkali, Richard M. Nelson, Alison Kukulka, Denice M. Spero, Erick R. R. Young, Eugene R. Hickey, Usha R. Patel, Jessi Wildeson, Ming-Hong Hao, Weimin Liu, Raj Betageri, Yancey David Ward, Della White, David S. Thomson, Mark E. Labadia, Dorothy M. Freeman, Maryanne L. Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2465-2469
The synthesis and in vitro activities of a series of succinyl-nitrile-based inhibitors of Cathepsin S are described. Several members of this class show nanomolar inhibition of the target enzyme as well as cellular potency. The inhibitors displaying t
Autor:
Kathy O’Shea, Denice M. Spero, Ronald L. Magolda, Mario G. Cardozo, Lisa H. Liu, Hanbo Hu, Derek Cogan, Heather Grbic, Thomas M. Farrell, John P. Wolak, John D. Ginn, Della White, Deborah D. Jeanfavre, Mohammed A. Kashem, Maryanne L. Brown, Anthony S. Prokopowicz, Carol Ann Homon, Erick R. R. Young, Joseph R. Woska, Paul Kaplita, Darren Disalvo, Georg Dahmann, Charles L. Cywin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:225-230
An uHTS campaign was performed to identify selective inhibitors of PKC-theta. Initial triaging of the hit set based on selectivity and historical analysis led to the identification of 2,4-diamino-5-nitropyrimidines as potent and selective PKC-theta i
Autor:
Sheri Rogers, Charles L. Cywin, Liang Tong, Susan Pav, Della White, Kathy Crane, Christopher Pargellis, Maryanne L. Brown
Publikováno v:
Nature Structural Biology. 4:311-316
The crystal structure of human p38 mitogen-activated protein (MAP) kinase in complex with a potent and highly specific pyridinyl-imidazole inhibitor has been determined at 2.0 A resolution. The structure of the kinase, which is in its unphosphorylate
Autor:
Maryanne L. Brown, Walter Davidson, Kathy Crane, Charles L. Cywin, Jerry L. Hopkins, Christopher Pargellis, Susan Pav, Liang Tong, Della White, Sheri Rogers
Publikováno v:
Protein Science. 6:242-245
The recombinant human p38 MAP kinase has been expressed and purified from both Escherichia coli and SF9 cells, and has been crystallized in two forms by the hanging drop vapor diffusion method using PEG as precipitant. Both crystal forms belong to sp
Autor:
Xiang Li, Jianfei Yang, Maryanne L. Brown, Mark E. Labadia, Della White, Carol D. Stearns, Lisa Stevens, Adedayo Hanidu, Jun Li, Tin Min Htut
Publikováno v:
European journal of immunology. 36(12)
Protein kinase C theta (PKCtheta) is essential for T cell activation, as it is required for the activation of NF-kappaB and expression of IL-2. PKCtheta has also been shown to affect NFAT activation and Th2 differentiation. To better understand the r
Autor:
Raymond A. Firestone, Maurice M. Morelock, Jessi Wildeson, Maryanne L. Brown, Christine A. Grygon, Jeffrey D. Peterson, Ernest L. Raymond, Peter R Kinkade, Walter Davidson, Denice M. Spero, Della White, Charles L. Cywin, Kathryn M Crane, Mcneil Daniel W, Jerry L. Hopkins, Mark E. Labadia
Publikováno v:
Bioorganicmedicinal chemistry. 11(5)
The design and synthesis of dipeptidyl disulfides and dipeptidyl benzoylhydrazones as selective inhibitors of the cysteine protease Cathepsin S are described. These inhibitors were expected to form a slowly reversible covalent adduct of the active si
Autor:
Yancey D, Ward, David S, Thomson, Leah L, Frye, Charles L, Cywin, Tina, Morwick, Michel J, Emmanuel, Renée, Zindell, Daniel, McNeil, Younes, Bekkali, Marc, Girardot, Matt, Hrapchak, Molly, DeTuri, Kathy, Crane, Della, White, Susan, Pav, Yong, Wang, Ming-Hong, Hao, Christine A, Grygon, Mark E, Labadia, Dorothy M, Freeman, Walter, Davidson, Jerry L, Hopkins, Maryanne L, Brown, Denice M, Spero, Marc, Giradot
Publikováno v:
Journal of Medicinal Chemistry. 46:882-882
The specificity of the immune response relies on processing of foreign proteins and presentation of antigenic peptides at the cell surface. Inhibition of antigen presentation, and the subsequent activation of T-cells, should, in theory, modulate the