Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Della C David"'
1
Akademický článek
A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. elegans.
Autor: Raimund Jung, Marie C Lechler, Ana Fernandez-Villegas, Chyi Wei Chung, Harry C Jones, Yoon Hee Choi, Maximilian A Thompson, Christian Rödelsperger, Waltraud Röseler, Gabriele S Kaminski Schierle, Ralf J Sommer, Della C David
Publikováno v: PLoS Biology, Vol 21, Iss 9, p e3002284 (2023)
During aging, proteostasis capacity declines and distinct proteins become unstable and can accumulate as protein aggregates inside and outside of cells. Both in disease and during aging, proteins selectively aggregate in certain tissues and not other
Externí odkaz: https://doaj.org/article/6e413ad3f27943b5974f39bac00f3cda
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2
Akademický článek
Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans
Autor: Chaolie Huang, Sara Wagner-Valladolid, Amberley D Stephens, Raimund Jung, Chetan Poudel, Tessa Sinnige, Marie C Lechler, Nicole Schlörit, Meng Lu, Romain F Laine, Claire H Michel, Michele Vendruscolo, Clemens F Kaminski, Gabriele S Kaminski Schierle, Della C David
Publikováno v: eLife, Vol 8 (2019)
Reduced protein homeostasis leading to increased protein instability is a common molecular feature of aging, but it remains unclear whether this is a cause or consequence of the aging process. In neurodegenerative diseases and other amyloidoses, spec
Externí odkaz: https://doaj.org/article/d304ea99735c4d8ea67842213713ac7f
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3
Akademický článek
Aging and the aggregating proteome
Autor: Della C David
Publikováno v: Frontiers in Genetics, Vol 3 (2012)
For all organisms promoting protein homeostasis is a high priority in order to optimize cellular functions and resources. However, there is accumulating evidence that aging leads to a collapse in protein homeostasis and widespread non-disease protein
Externí odkaz: https://doaj.org/article/7678f407d97a46089e90c4d02053f211
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4
Akademický článek
Widespread protein aggregation as an inherent part of aging in C. elegans.
Autor: Della C David, Noah Ollikainen, Jonathan C Trinidad, Michael P Cary, Alma L Burlingame, Cynthia Kenyon
Publikováno v: PLoS Biology, Vol 8, Iss 8, p e1000450 (2010)
Aberrant protein aggregation is a hallmark of many age-related diseases, yet little is known about whether proteins aggregate with age in a non-disease setting. Using a systematic proteomics approach, we identified several hundred proteins that becom
Externí odkaz: https://doaj.org/article/264c60190e934e96a6b5874eb4d04f9a
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5
Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report
Autor: Jennifer Cable, Eilika Weber‐Ban, Tim Clausen, Kylie J. Walters, Michal Sharon, Daniel J. Finley, Yangnan Gu, John Hanna, Yue Feng, Sascha Martens, Anne Simonsen, Malene Hansen, Hong Zhang, Jonathan M. Goodwin, Alessio Reggio, Chunmei Chang, Liang Ge, Brenda A. Schulman, Raymond J. Deshaies, Ivan Dikic, J. Wade Harper, Ingrid E. Wertz, Nicolas H. Thomä, Mikołaj Słabicki, Judith Frydman, Ursula Jakob, Della C. David, Eric J. Bennett, Carolyn R. Bertozzi, Richa Sardana, Vinay V. Eapen, Serena Carra
Publikováno v: Annals of the New York Academy of Sciences 1510(1), 79-99 (2022). doi:10.1111/nyas.14745
Targeted protein degradation is critical for proper cellular function and development. Protein degradation pathways, such as the ubiquitin proteasomes system, autophagy, and endosome-lysosome pathway, must be tightly regulated to ensure proper elimin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88110e83b56645cb723743deb2706a33
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7
Tissue-specific safety mechanism results in opposite protein aggregation patterns during aging
Autor: Ralf J. Sommer, Christian Rödelsperger, Raimund Jung, Waltraud Röseler, Marie C. Lechler, Della C. David
During aging, proteostasis capacity declines and aggregation-prone proteins become instable, accumulating in protein aggregates both inside and outside cells. Both in disease and during aging, proteins selectively aggregate in certain tissues and not
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5f85266c1300da9443ab3b2852ca657
https://doi.org/10.1101/2020.12.04.409771
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8
Extracellular proteostasis prevents aggregation during pathogenic attack
Autor: Raimund Jung, Waltraud Röseler, Sinem Agilkaya, Ivan Gallotta, Martin Haslbeck, Ralf J. Sommer, Della C. David, Christian Rödelsperger, Chaolie Huang, Jane L. Blersch, Aneet Sandhu, Maximilian Peters
Publikováno v: Nature / Physical science 584(7821), 410-414 (2020). doi:10.1038/s41586-020-2461-z
In metazoans, the secreted proteome participates in intercellular signalling and innate immunity, and builds the extracellular matrix scaffold around cells. Compared with the relatively constant intracellular environment, conditions for proteins in t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7551d1df24598615d1d5f8f956f7e582
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9
Reduced insulin/IGF-1 signaling restores the dynamic properties of key stress granule proteins during aging
Autor: Marie C. Lechler, Della C. David
Publikováno v: Prion
Prion 11(5), 313-322 (2017). doi:10.1080/19336896.2017.1356559
Low complexity (LC) prion-like domains are over-represented among RNA-binding proteins (RBPs) and contribute to the dynamic nature of RNA granules. Importantly, several neurodegenerative diseases are characterized by cytoplasmic “solid” aggregate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0476e5d616c18ca5cebfe1e509b72c0a
http://europepmc.org/articles/PMC7030885
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