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Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model.

Autor: Wang W; Biologics Clinical Pharmacology, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., McIntosh TS; Biologics Clinical Pharmacology, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Jiang X; Biologics Clinical Pharmacology, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Doddareddy R; Biologics Clinical Pharmacology, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Dell EC; Biologics Clinical Pharmacology, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Zhou H; Biologics Clinical Pharmacology, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA. hzhou2@its.jnj.com.; Quantitative Sciences, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA. hzhou2@its.jnj.com.

Publikováno v: Pharmaceutical research [Pharm Res] 2016 Apr; Vol. 33 (4), pp. 1040-9. Date of Electronic Publication: 2015 Dec 30.