Haloperidol vs. placebo for the treatment of delirium in ICU patients:a pre-planned, secondary Bayesian analysis of the AID-ICU trial

Autor: Nina C. Andersen-Ranberg, Lone Musaeus Poulsen, Anders Perner, Johanna Hästbacka, Matthew Morgan, Giuseppe Citerio, Marie Oxenbøll Collet, Sven-Olaf Weber, Anne Sofie Andreasen, Morten Bestle, Bülent Uslu, Helle Scharling Pedersen, Louise Gramstrup Nielsen, Kjeld Damgaard, Troels Bek Jensen, Trine Sommer, Nilanjan Dey, Ole Mathiesen, Anders Granholm

Publikováno v: Andersen-Ranberg, N C, Poulsen, L M, Perner, A, Hästbacka, J, Morgan, M, Citerio, G, Collet, M O, Weber, S-O, Andreasen, A S, Bestle, M, Uslu, B, Pedersen, H S, Nielsen, L G, Damgaard, K, Jensen, T B, Sommer, T, Dey, N, Mathiesen, O & Granholm, A 2023, ' Haloperidol vs. placebo for the treatment of delirium in ICU patients : a pre-planned, secondary Bayesian analysis of the AID-ICU trial ', Intensive Care Medicine, vol. 49, no. 4, pp. 411-420 . https://doi.org/10.1007/s00134-023-07024-9
Andersen-Ranberg, N C, Poulsen, L M, Perner, A, Hästbacka, J, Morgan, M, Citerio, G, Collet, M O, Weber, S O, Andreasen, A S, Bestle, M, Uslu, B, Pedersen, H S, Nielsen, L G, Damgaard, K, Jensen, T B, Sommer, T, Dey, N, Mathiesen, O & Granholm, A 2023, ' Haloperidol vs. placebo for the treatment of delirium in ICU patients : a pre-planned, secondary Bayesian analysis of the AID–ICU trial ', Intensive Care Medicine, vol. 49, no. 4, pp. 411-420 . https://doi.org/10.1007/s00134-023-07024-9

Purpose: The AID-ICU trial was a randomised, blinded, placebo-controlled trial investigating effects of haloperidol versus placebo in acutely admitted, adult patients admitted in intensive care unit (ICU) with delirium. This pre-planned Bayesian anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d9bd26d7394cb7518f538c5c05cfb8
https://pure.au.dk/portal/da/publications/haloperidol-vs-placebo-for-the-treatment-of-delirium-in-icu-patients(4684bd74-4dc0-4665-8ebb-be1f3ba51ca1).html

Agents intervening against delirium in the intensive care unit trial-Protocol for a secondary Bayesian analysis

Autor: Andersen-Ranberg, Nina, Poulsen, Lone M, Perner, Anders, Hästbacka, Johanna, Morgan, Matthew P G, Citerio, Giuseppe, Oxenbøll-Collet, Marie, Weber, Sven-Olaf, Andreasen, Anne Sofie, Bestle, Morten H, Uslu, Bülent, Pedersen, Helle B S, Nielsen, Louise G, Damgaard, Kjeld, Jensen, Troels B, Sommer, Trine, Dey, Nilanjan, Mathiesen, Ole, Granholm, Anders

Publikováno v: Andersen-Ranberg, N, Poulsen, L M, Perner, A, Hästbacka, J, Morgan, M P G, Citerio, G, Oxenbøll-Collet, M, Weber, S-O, Andreasen, A S, Bestle, M H, Uslu, B, Pedersen, H B S, Nielsen, L G, Damgaard, K, Jensen, T B, Sommer, T, Dey, N, Mathiesen, O & Granholm, A 2022, ' Agents intervening against delirium in the intensive care unit trial-Protocol for a secondary Bayesian analysis ', Acta Anaesthesiologica Scandinavica, vol. 66, no. 7, pp. 898-903 . https://doi.org/10.1111/aas.14091

Agents intervening against delirium in the intensive care unit trial-Protocol for a secondary Bayesian analysis BACKGROUND: Delirium is highly prevalent in the intensive care unit (ICU) and is associated with high morbidity and mortality. The antipsy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::408f508b2cd07882bc206297407c5caf
https://pure.au.dk/portal/da/publications/agents-intervening-against-delirium-in-the-intensive-care-unit-trialprotocol-for-a-secondary-bayesian-analysis(2d986a7c-12a4-4ebf-a3a4-18f04ffd4c83).html

Efficacy of halopeRIdol to decrease the burden of Delirium In adult Critically ill patiEnts (EuRIDICE): study protocol for a prospective randomised multi-centre double-blind placebo-controlled clinical trial in the Netherlands

Autor: Smit, Lisa, Trogrlic, Zoran, Devlin, JW, Osse, R.J., Ponssen, H, Slooter, AJC, Hunfeld, Nicole, Rietdijk, Wim, Gommers, Diederik, van der Jagt, Mathieu, Boogaard, M, Brouwers, A, Lens, JA, van der Meer, BJM, Schoonderbeek, FJ, Simons, KS, Berger, E, Bouman, A, Del Campo, M, van Duijn, Ditty, Embden-van Donk, H, de Graaf, D, Hoogendoorn, E, Ormskerk, Patricia, Roovers, N, Toscano, E, Vileito, Alicija, van Zuylen, T, Exler, Claartje, van den Berg, Esther, van Meeteren, Jetty, Koopmanschap, Marc

Publikováno v: BMJ Open, 10
BMJ Open, 10, 9
BMJ Open, 10(9):e036735. BMJ Publishing Group
BMJ Open
BMJ Open, Vol 10, Iss 9 (2020)

IntroductionDelirium in critically ill adults is associated with prolonged hospital stay, increased mortality and greater cognitive and functional decline. Current practice guideline recommendations advocate the use of non-pharmacological strategies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839ee7dc8ba11dee93e41a471910c291
http://hdl.handle.net/2066/225437

Efficacy and safety of haloperidol for in-hospital delirium prevention and treatment

Publikováno v: European Journal of Internal Medicine. 27:14-23

OBJECTIVE: Haloperidol is generally considered the drug of choice for in-hospital delirium management. We conducted a systematic review to evaluate the evidence for the efficacy and safety of haloperidol for the prevention and treatment of delirium i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4612::f65ec36abd17bc9f304dcfd539ff4908
https://research.vu.nl/en/publications/87118e0e-ae6b-42ce-8d0f-6edb2fb865fe

Prophylactic Haloperidol Effects on Long-term Quality of Life in Critically Ill Patients at High Risk for Delirium : Results of the REDUCE Study

Publikováno v: Anesthesiology. 131(2):328

BACKGROUND: Delirium incidence in intensive care unit patients is high and associated with impaired long-term outcomes. The use of prophylactic haloperidol did not improve short-term outcome among critically ill adults at high risk of delirium. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::fb3a94a51b9be0248dadfcce8750dc06
https://doi.org/10.1097/aln.0000000000002812