Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Delira Robbins"'
Publikováno v:
Molecules, Vol 18, Iss 7, Pp 7389-7406 (2013)
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of their target genes. NRs play important roles in many human diseases, including metabolic diseases and cancer, and are therefore a key class of therapeu
Externí odkaz:
https://doaj.org/article/477c78c5c0d244f584e093b2f54e3b1b
Autor:
Delira Robbins, Xin Gu, Runhua Shi, Jianfeng Liu, Fei Wang, Jacqulyne Ponville, Joe M McCord, Yunfeng Zhao
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11902 (2010)
Protandim, a well defined dietary combination of 5 well-established medicinal plants, is known to induce endogenous antioxidant enzymes, such as manganese superoxide dismutase (MnSOD). Our previous studies have shown through the induction of various
Externí odkaz:
https://doaj.org/article/cf1941322fde4a5f9dd867caf91ada8c
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5284 (2009)
Oxidative stress is an important contributor to cancer development. Consistent with that, antioxidant enzymes have been demonstrated to suppress tumorigenesis when being elevated both in vitro and in vivo, making induction of these enzymes a more pot
Externí odkaz:
https://doaj.org/article/e553577457704e6aa8cf4b4e89008cf4
Publikováno v:
Cell Death Discovery
The pregnane X receptor (PXR) is well established as a nuclear receptor that has a central role in xenobiotic metabolism and disposition. However, emerging evidence suggests that PXR is also a regulator of apoptosis, promoting a malignant phenotype b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d37a24d85f618ae778c86851663bde
https://doi.org/10.1038/cddiscovery.2016.23
https://doi.org/10.1038/cddiscovery.2016.23
PXR is a xenobiotic receptor that regulates drug metabolism by regulating the expression of drug-metabolizing enzymes including CYP3A4. It can be modulated by chemicals with different structures, functional groups and sizes. X-ray crystal structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4853782d59b0ee90a0316638f18dcb84
https://europepmc.org/articles/PMC4778391/
https://europepmc.org/articles/PMC4778391/
Autor:
Delira Robbins, Yunfeng Zhao
Publikováno v:
Journal of Signal Transduction
The formation of reactive oxygen species (ROS) is a result of incomplete reduction of molecular oxygen during cellular metabolism. Although ROS has been shown to act as signaling molecules, it is known that these reactive molecules can act as prooxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2df0a1ee8440050b94ff7b52db5315
https://doi.org/10.1155/2012/101465
https://doi.org/10.1155/2012/101465
Publikováno v:
Open Journal of Apoptosis. :19-24
Recently, redox factor-1 (Ref-1) has received considerable attention as an enzyme for stimulating tumor cell growth. We hypothesized that Ref-1 is upregulated during the early stage of tumorigenesis. Utilizing both tumor promotion sensitive P+ and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4b51e2beb2a0082fe75ecd3a8ba704b
https://doi.org/10.4236/ojapo.2012.13003
https://doi.org/10.4236/ojapo.2012.13003
Autor:
Arlan Richardson, Jennifer A. Wittwer, Xinggui Shen, Yunfeng Zhao, Fei Wang, Holly Van Remmen, Delira Robbins, Christopher G. Kevil, Ting-Ting Huang, Sarah Codarin
Publikováno v:
Cancer Prevention Research. 4:1476-1484
Differentiated cells primarily metabolize glucose for energy via the tricarboxylic acid cycle and oxidative phosphorylation, but cancer cells thrive on a different mechanism to produce energy, characterized as the Warburg effect, which describes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6dd91ff36f233728da054143a0b865
https://doi.org/10.1158/1940-6207.capr-11-0028
https://doi.org/10.1158/1940-6207.capr-11-0028
Autor:
Delira Robbins, Yunfeng Zhao
Publikováno v:
International Journal of Molecular Sciences, Vol 12, Iss 8, Pp 5285-5293 (2011)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Uncoupling proteins (UCPs) belong to a family of mitochondrial carrier proteins that are present in the mitochondrial inner membrane. UCP1 was first identified followed by its two homologs, UCP2 and UCP3. The physiological functions of UCP include lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff185ec005af2005059d983de58da515
http://www.mdpi.com/1422-0067/12/8/5285/
http://www.mdpi.com/1422-0067/12/8/5285/
Publikováno v:
Drug discovery today. 20(5)
Nuclear receptors such as the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are xenobiotic receptors regulating not only drug metabolism and disposition but also various human diseases such as cancer, diabetes, inflammatory dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc006e05bf9a0a47163ba5a9644302e
https://pubmed.ncbi.nlm.nih.gov/25463033
https://pubmed.ncbi.nlm.nih.gov/25463033