Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Delilah Hendriks"'
Autor:
Delilah Hendriks, Benedetta Artegiani, Thanasis Margaritis, Iris Zoutendijk, Susana Chuva de Sousa Lopes, Hans Clevers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mechanisms underlying human hepatocyte growth in development and regeneration are incompletely understood. In vitro, human fetal hepatocytes (FH) can be robustly grown as organoids, while adult primary human hepatocyte (PHH) organoids remain
Externí odkaz:
https://doaj.org/article/2af830c56ec0454f8a7fc1b29bfbca34
Autor:
Anna Pagliaro, Roxy Finger, Iris Zoutendijk, Saskia Bunschuh, Hans Clevers, Delilah Hendriks, Benedetta Artegiani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Pluripotent stem cell (PSC)-derived human brain organoids enable the study of human brain development in vitro. Typically, the fate of PSCs is guided into subsequent specification steps through static medium switches. In vivo, morphogen grad
Externí odkaz:
https://doaj.org/article/13e3eca99244404e9802541b35f6f911
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
Autor:
Maarten H. Geurts, Shashank Gandhi, Matteo G. Boretto, Ninouk Akkerman, Lucca L. M. Derks, Gijs van Son, Martina Celotti, Sarina Harshuk-Shabso, Flavia Peci, Harry Begthel, Delilah Hendriks, Paul Schürmann, Amanda Andersson-Rolf, Susana M. Chuva de Sousa Lopes, Johan H. van Es, Ruben van Boxtel, Hans Clevers
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Optimization of CRISPR/Cas9-mediated genome engineering has resulted in base editors that hold promise for mutation repair and disease modeling. Here, we demonstrate the application of base editors for the generation of complex tumor models
Externí odkaz:
https://doaj.org/article/118466422c7b4a548268957a251cfb11
Autor:
Annie S. P. Yang, Devanjali Dutta, Kai Kretzschmar, Delilah Hendriks, Jens Puschhof, Huili Hu, Kim E. Boonekamp, Youri van Waardenburg, Susana M. Chuva de Sousa Lopes, Geert-Jan van Gemert, Johannes H. W. de Wilt, Teun Bousema, Hans Clevers, Robert W. Sauerwein
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Plasmodium falciparum (Pf) parasite development in liver represents the initial step of the life-cycle in the human host after a Pf-infected mosquito bite. While an attractive stage for life-cycle interruption, understanding of parasite-hepa
Externí odkaz:
https://doaj.org/article/5c88670c6cde4830afc419a55a86cad4
Autor:
Laura Rüland, Francesco Andreatta, Simone Massalini, Susana Chuva de Sousa Lopes, Hans Clevers, Delilah Hendriks, Benedetta Artegiani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Fibrolamellar carcinoma (FLC) is a lethal primary liver cancer, affecting young patients in absence of chronic liver disease. Molecular understanding of FLC tumorigenesis is limited, partly due to the scarcity of experimental models. Here, w
Externí odkaz:
https://doaj.org/article/99e2cf8fc901400ca1ace1c5e4c2a58d
Autor:
Arif Ibrahim Ardisasmita, Imre F. Schene, Indi P. Joore, Gautam Kok, Delilah Hendriks, Benedetta Artegiani, Michal Mokry, Edward E. S. Nieuwenhuis, Sabine A. Fuchs
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
A systematic comparison of transcriptomes across different hepatocyte models provides a valuable resource to determine the most suitable model for a particular application or research question.
Externí odkaz:
https://doaj.org/article/403bc2d40d484beeaa9b734f875b3b5d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/072328ce38bb4374ad6a64d27feff035
Autor:
Flavio Bonanini, Dorota Kurek, Sara Previdi, Arnaud Nicolas, Delilah Hendriks, Sander de Ruiter, Marine Meyer, Maria Clapés Cabrer, Roelof Dinkelberg, Silvia Bonilla García, Bart Kramer, Thomas Olivier, Huili Hu, Carmen López-Iglesias, Frederik Schavemaker, Erik Walinga, Devanjali Dutta, Karla Queiroz, Karel Domansky, Bob Ronden, Jos Joore, Henriette L. Lanz, Peter J. Peters, Sebastiaan J. Trietsch, Hans Clevers, Paul Vulto
Publikováno v:
Angiogenesis
Angiogenesis, 25(4), 455-470. Springer, Cham
Angiogenesis, 25(4), 455-470. Springer Netherlands
Angiogenesis, 25(4), 455-470. Springer, Cham
Angiogenesis, 25(4), 455-470. Springer Netherlands
With recent progress in modeling liver organogenesis and regeneration, the lack of vasculature is becoming the bottleneck in progressing our ability to model human hepatic tissues in vitro. Here, we introduce a platform for routine grafting of liver
Autor:
Delilah Hendriks, Jos F. Brouwers, Karien Hamer, Maarten H. Geurts, Léa Luciana, Simone Massalini, Carmen López-Iglesias, Peter J. Peters, Maria J. Rodríguez-Colman, Susana Chuva de Sousa Lopes, Benedetta Artegiani, Hans Clevers
Publikováno v:
Nature Biotechnology. Nature Publishing Group
The lack of registered drugs for nonalcoholic fatty liver disease (NAFLD) is partly due to the paucity of human-relevant models for target discovery and compound screening. Here we use human fetal hepatocyte organoids to model the first stage of NAFL
Autor:
Victor Tirolle, Adrien Krug, Emma Bokobza, Mattijs Bulcaen, Marjolein M. Ensinck, Maarten H. Geurts, Delilah Hendriks, François Vermeulen, Frédéric Larbret, Alejandra Gutierrez-Guerrero, Louise Medaer, Rik Gijsbers, Philippe E. Mangeot, Hans Clevers, Marianne S. Carlon, Frederic Bost, Els Verhoeyen
Genome engineering has become more accessible thanks to the RNA programmable endonucleases such as the CRISPR/Cas9 system. However, using this editing technology in synthetic organs called ‘organoids’ is still very inefficient. This is due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd862d8b5bbe9ad027009690e7538a3b
https://doi.org/10.1101/2022.08.04.502859
https://doi.org/10.1101/2022.08.04.502859