Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Delilah F G, Hendriks"'
Autor:
Tracey Hurrell, Vlasia Kastrinou-Lampou, Achilleas Fardellas, Delilah F. G. Hendriks, Åsa Nordling, Inger Johansson, Audrey Baze, Céline Parmentier, Lysiane Richert, Magnus Ingelman-Sundberg
Publikováno v:
Cells, Vol 9, Iss 4, p 964 (2020)
Non-alcoholic fatty liver disease affects approximately one billion adults worldwide. Non-alcoholic steatohepatitis (NASH) is a progressive disease and underlies the advancement to liver fibrosis, cirrhosis, and hepatocellular carcinoma, for which th
Externí odkaz:
https://doaj.org/article/50d081ebb12549308162f6e2a8813916
Autor:
Etienne P A Neve, Harald Köfeler, Delilah F G Hendriks, Åsa Nordling, Vladimir Gogvadze, Souren Mkrtchian, Erik Näslund, Magnus Ingelman-Sundberg
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138487 (2015)
Recently two novel enzymes were identified in the outer mitochondrial membrane, mARC1 and mARC2. These molybdenum containing enzymes can reduce a variety of N-hydroxylated compounds, such as N-hydroxy-guanidines and sulfohydroxamic acids, as well as
Externí odkaz:
https://doaj.org/article/ac02ed25d541439ebe9d04bfe6ab28ba
Autor:
Hans Clevers, Huili Hu, Delilah F. G. Hendriks, Susana M. Chuva de Sousa Lopes, Benedetta Artegiani
Publikováno v:
Nature Protocols. Nature Publishing Group
Nature Protocols, 16(1), 182-217. NATURE RESEARCH
Nature Protocols, 16(1), 182-217. NATURE RESEARCH
The liver is composed of two epithelial cell types: hepatocytes and liver ductal cells. Culture conditions for expansion of human liver ductal cells in vitro as organoids were previously described in a protocol; however, primary human hepatocytes rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95202f3296e19f7a65ded4744dc59eaa
https://hdl.handle.net/1887/3196053
https://hdl.handle.net/1887/3196053
Publikováno v:
Cell stem cell. 27(5)
CRISPR-Cas technology has revolutionized biological research and holds great therapeutic potential. Here, we review CRISPR-Cas systems and their latest developments with an emphasis on application to human cells. We also discuss how different CRISPR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08505312102a26e5241f5830284b712f
https://pubmed.ncbi.nlm.nih.gov/33157047
https://pubmed.ncbi.nlm.nih.gov/33157047
Autor:
Sarah A. Teichmann, Peter J. Peters, Aurelia Saftien, Franka H van der Linden, Reinier van der Linden, Maarten H. Geurts, Alexander Ross, Cayetano Pleguezuelos-Manzano, Julia Bauzá-Martinez, Albert J. R. Heck, Hans Clevers, Hugo J. Snippert, Delilah F. G. Hendriks, Carmen López-Iglesias, Benedetta Artegiani, Georg A. Busslinger, Wei Wu, Rasa Elmentaite, Yotam E. Bar-Ephraim, Willine J. van de Wetering, Charelle Boot, Amanda Andersson-Rolf, Harry Begthel, Adriana Martinez-Silgado, Kai Kretzschmar, Bas Ponsioen, Kylie R. James, Joep Beumer, Joachim Goedhart, Jens Puschhof, Yorick Post, Matthias Zilbauer
Publikováno v:
Cell, 181(6), 1291-1306.e19. Elsevier B.V.
Cell, 181(6), 1291-+. Cell Press
Cell
Cell, 181(6), 1291-+. Cell Press
Cell
Enteroendocrine cells (EECs) sense intestinal content and release hormones to regulate gastrointestinal activity, systemic metabolism, and food intake. Little is known about the molecular make-up of human EEC subtypes and the regulated secretion of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb3dc1f58bdcd8d9787afa61b297e1c
https://pure.knaw.nl/portal/en/publications/73363b0c-8425-47f7-bb59-62156970642e
https://pure.knaw.nl/portal/en/publications/73363b0c-8425-47f7-bb59-62156970642e
This protocol outlines reagents and procedures to generate human knock-in organoids using our established strategy named CRISPR-HOT. The protocol describes the plasmids to be used and strategies to generate knock-in organoids from different organs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13ac3af43c00411b5c2203794d1a97bf
https://doi.org/10.21203/rs.3.pex-791/v1
https://doi.org/10.21203/rs.3.pex-791/v1
Autor:
Susana M. Chuva de Sousa Lopes, Sander J. Tans, Benedetta Artegiani, Xuan Zheng, Delilah F. G. Hendriks, Joep Beumer, Jeroen S. van Zon, Indi Joore, Rutger N.U. Kok, Hans Clevers
Publikováno v:
Nature Cell Biology, 22(3), 321-331. Nature Publishing Group
Nature Cell Biology, 22, 321-331. NATURE PUBLISHING GROUP
Nature Cell Biology, 22, 321-331. NATURE PUBLISHING GROUP
CRISPR-Cas9 technology has revolutionized genome editing and is applicable to the organoid field. However, precise integration of exogenous DNA sequences into human organoids is lacking robust knock-in approaches. Here, we describe CRISPR-Cas9-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c9a86ff1a9e9ce9fa4fbc7ba8103d8
https://hdl.handle.net/1887/3181947
https://hdl.handle.net/1887/3181947
Autor:
Michael L. Shuler, Delilah F. G. Hendriks, Betty C. Hakkert, Alicia Paini, Peter M.J. Bos, Bart Spee, Marije Strikwold, Ian Sorrell, Paul Jennings, Ans Punt, Huan Yang, Hans Bouwmeester, Bas J. Blaauboer, Minne B. Heringa, Meike van der Zande, Rosalinde Masereeuw, Martijn Rooseboom, Ad A. C. M. Peijnenburg, Mathieu Vinken, Andries D. van der Meer, Sandra Coecke, Nynke I. Kramer, Sibylle Neuhoff
Publikováno v:
ALTEX.
For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion (ADME/biokinetics) in chemical risk evaluations are a bottleneck. To enhance th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d506975c9be110527fa44b2ace726336
https://doi.org/10.14573/altex.2003242
https://doi.org/10.14573/altex.2003242
Autor:
Tracey Hurrell, Céline Parmentier, Philippe Bachellier, Delilah F. G. Hendriks, Catherine Schuster, Bruno Heyd, Lysiane Richert, Magnus Ingelman-Sundberg, Audrey Baze
Publikováno v:
Tissue Engineering Part C: Methods
Recent advances in the development of various culture platforms are promising for achieving more physiologically relevant in vitro hepatic models using primary human hepatocytes (PHHs). Previous studies have shown the value of PHHs three-dimensional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e269b32ec8221ea948817aea0255997
https://doi.org/10.1089/ten.tec.2018.0134
https://doi.org/10.1089/ten.tec.2018.0134
Autor:
Rowena Sison-Young, Min Wei Wong, Chris S. Pridgeon, Michael J. Cross, Christopher E. Goldring, John Greenman, James E. Sidaway, Vitalina Gryshkova, Joseph Leedale, Paul Walker, Tahera Ansari, Emma L. Wilkinson, Laurence Launay, Susan Gibbs, B. Kevin Park, Tobias Heckel, Stefan Przyborski, R. N. Bearon, Constanze Schlott, Minne B. Heringa, Delilah F. G. Hendriks
Publikováno v:
Pridgeon, C S, Schlott, C, Wong, M W, Heringa, M B, Heckel, T, Leedale, J, Launay, L, Gryshkova, V, Przyborski, S, Bearon, R N, Wilkinson, E L, Ansari, T, Greenman, J, Hendriks, D F G, Gibbs, S, Sidaway, J, Sison-Young, R L, Walker, P, Cross, M J, Park, B K & Goldring, C E P 2018, ' Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms ', Archives of Toxicology, vol. 92, no. 2, pp. 557-569 . https://doi.org/10.1007/s00204-018-2152-9
Archives of Toxicology
Archives of Toxicology
The development of improved, innovative models for the detection of toxicity of drugs, chemicals, or chemicals in cosmetics is crucial to efficiently bring new products safely to market in a cost-effective and timely manner. In addition, improvement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abac4eb357d91a6ac35143bd8f1341eb
https://doi.org/10.1007/s00204-018-2152-9
https://doi.org/10.1007/s00204-018-2152-9