Genome-wide association study of circulating interleukin 6 levels identifies novel loci

Autor: Martina Müller-Nurasyid, Jerome I. Rotter, David M. Evans, John P. Kemp, Emelia J. Benjamin, Graciela E. Delgado, Vilmundur Gudnason, Ann Hammarstedt, Panos Deloukas, Aroon D. Hingorani, Riccardo E. Marioni, David Stacey, Jenny van Dongen, Eric Boerwinkle, Joachim Heinrich, Yongmei Liu, S. Goya Wannamethee, Delilah Zabaneh, Braxton D. Mitchell, Marie Standl, Jackie F. Price, Maria G. Stathopoulou, Yoav Ben-Shlomo, Joris Deelen, Eero Kajantie, Mohammadreza Abdollahi, Christie M. Ballantyne, Johan G. Eriksson, Ilkka Seppälä, Elnaz Naderi, Barbara J. Jefferis, Richard W Morris, Nicholas J. Timpson, George Dedoussis, Sirpa Jalkanen, Mika Kivimäki, Perminder S. Sachdev, Diana van Heemst, Melanie Waldenberger, Gaurav Singhal, Elisabeth Thiering, Olli T. Raitakari, Anders Hamsten, Zoltán Kutalik, L. Bain, Eco J. C. de Geus, Tarunveer S. Ahluwalia, Yuri Milaneschi, Hubert Scharnagl, Juan P. Casas, Georg Homuth, Claes Ohlsson, Abbas Dehghan, Nicola J. Armstrong, Behrooz Z. Alizadeh, Terho Lehtimäki, Steve E. Humphries, Naveed Sattar, Bram P. Prins, Peter Rossing, Sophie Visvikis-Siest, Joana A. Revez, Ilja M. Nolte, Stella Trompet, Harold Snieder, Marian Beekman, Diana Marek, Beate St Pourcain, Thorkild I. A. Sørensen, Silvia Naitza, Karen A. Mather, Uwe Völker, Eline Slagboom, Tina Shah, Magdalene C. Jawahar, Jens Baumert, Alexander Teumer, Dorret I. Boomsma, Marcus E. Kleber, Peter Vollenweider, Wolfgang Koenig, Brenda W.J.H. Penninx, Kenneth Rice, Ian J. Deary, Pedro Marques-Vidal, Donna K. Arnett, Eleonora Porcu, Jouke-Jan Hottenga, Maria Sabater-Lleal, Bruce M. Psaty, Matthias Nauck, Dan Mellström, Joel Eriksson, Bernhard T. Baune, Debbie A Lawlor, Catherine Toben, Peter H. Whincup, Toshiko Tanaka, Stavroula Kanoni, Katri Räikkönen, Gonneke Willemsen, Bengt Sennblad, Julian N. Trollor, Yalda Jamshidi, Sarah E. Harris, Jari Lahti, Joshua C. Bis, Peter Durda, Yen Pei C. Chang, Jorgen Engmann, Tom R. Gaunt, Stella Aslibekyan, Anbupalam Thalamuthu, Mary F. Feitosa, Angela Silveira, Tine Jess, Stela McLachlan, J. Wouter Jukema, Chen Lu, Simon P. Mooijaart, Tim D. Spector, Harald Grallert, Winfried März, Alexandros M. Petrelis, Manuel A. R. Ferreira, Meena Kumari

Publikováno v: Human molecular genetics, 30(5), 393-409. Oxford University Press
Human Molecular Genetics, 30(5), 393-409. OXFORD UNIV PRESS
Human Molecular Genetics
Ahluwalia, T S, De Geus, E, Milaneschi, Y, Hottenga, J-J, Van Dongen, J, Willemsen, G, Boomsma, D I, Alizadeh, B Z & CHARGE Inflammation Working Group 2021, ' Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci ', Human molecular genetics, vol. 30, no. 5, pp. 393-409 . https://doi.org/10.1093/hmg/ddab023
Hum Mol Genet
Human Molecular Genetics, 30(5), 393-409. Oxford University Press
Human molecular genetics, vol. 30, no. 5, pp. 393-409
CHARGE Inflammation working group 2021, ' Genome-wide association study of circulating interleukin 6 levels identifies novel loci ', Human Molecular Genetics, vol. 30, no. 5, pp. 393-409 . https://doi.org/10.1093/hmg/ddab023
Human Molecular Genetics, Oxford University Press (OUP), 2021, ⟨10.1093/hmg/ddab023⟩
Hum. Mol. Genet. 30, 393-409 (2021)
Ahluwalia, T S, Prins, B P, Abdollahi, M, Armstrong, N J, Aslibekyan, S, Bain, L, Jefferis, B, Baumert, J, Beekman, M, Ben-shlomo, Y, Bis, J C, Mitchell, B D, De Geus, E, Delgado, G E, Marek, D, Eriksson, J, Kajantie, E, Kanoni, S, Kemp, J P, Lu, C, Marioni, R E, Mclachlan, S, Milaneschi, Y, Nolte, I M, Petrelis, A M, Porcu, E, Sabater-lleal, M, Naderi, E, Seppälä, I, Shah, T, Singhal, G, Standl, M, Teumer, A, Thalamuthu, A, Thiering, E, Trompet, S, Ballantyne, C M, Benjamin, E J, Casas, J P, Toben, C, Dedoussis, G, Deelen, J, Durda, P, Engmann, J, Feitosa, M F, Grallert, H, Hammarstedt, A, Harris, S E, Homuth, G, Hottenga, J, Jalkanen, S, Jamshidi, Y, Jawahar, M C, Jess, T, Kivimaki, M, Kleber, M E, Lahti, J, Liu, Y, Marques-vidal, P, Mellström, D, Mooijaart, S P, Müller-nurasyid, M, Penninx, B, Revez, J A, Rossing, P, Räikkönen, K, Sattar, N, Scharnagl, H, Sennblad, B, Silveira, A, Pourcain, B S, Timpson, N J, Trollor, J, Van Dongen, J, Van Heemst, D, Visvikis-siest, S, Vollenweider, P, Völker, U, Waldenberger, M, Willemsen, G, Zabaneh, D, Morris, R W, Arnett, D K, Baune, B T, Boomsma, D I, Chang, Y C, Deary, I J, Deloukas, P, Eriksson, J G, Evans, D M, Ferreira, M A, Gaunt, T, Gudnason, V, Hamsten, A, Heinrich, J, Hingorani, A, Humphries, S E, Jukema, J W, Koeing, W, Kumari, M, Kutalik, Z, Lawlor, D A, Lehtimäki, T, März, W, Mather, K, Naitza, S, Nauck, M, Ohlsson, C, Price, J F, Raitakari, O, Rice, K, Sachdev, P S, Slagboom, E, Sørensen, T I A, Spector, T, Stacey, D, Stathopoulou, M G, Tanaka, T, Wannamethee, S G, Whincup, P, Rotter, J I, Dehghan, A, Boerwinkle, E, Psaty, B M, Snieder, H & Alizadeh, B Z 2021, ' Genome-wide association study of circulating Interleukin 6 levels identifies novel loci ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddab023
European Journal of Human Genetics, 28(SUPPL 1), 307-308. Nature Publishing Group
Ahluwalia, T S, Prins, B P, Abdollahi, M, Armstrong, N J, Aslibekyan, S, Bain, L, Jefferis, B, Baumert, J, Beekman, M, Ben-Shlomo, Y, Bis, J C, Mitchell, B D, de Geus, E, Delgado, G E, Marek, D, Eriksson, J, Kajantie, E, Kanoni, S, Kemp, J P, Lu, C, Marioni, R E, McLachlan, S, Milaneschi, Y, Nolte, I M, Petrelis, A M, Porcu, E, Sabater-Lleal, M, Naderi, E, Seppälä, I, Shah, T, Singhal, G, Standl, M, Teumer, A, Thalamuthu, A, Thiering, E, Trompet, S, Ballantyne, C M, Benjamin, E J, Casas, J P, Toben, C, Dedoussis, G, Deelen, J, Durda, P, Engmann, J, Feitosa, M F, Grallert, H, Hammarstedt, A, Jess, T, Rossing, P, Sørensen, T I A & CHARGE Inflammation Working Group 2021, ' Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci ', Human Molecular Genetics, vol. 30, no. 5, pp. 393–409 . https://doi.org/10.1093/hmg/ddab023

Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175e56e119fa2ad648eb40764e8c6ee2
https://doi.org/10.1093/hmg/ddab023

Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium.

Autor: Tina Shah, Jorgen Engmann, Caroline Dale, Sonia Shah, Jon White, Claudia Giambartolomei, Stela McLachlan, Delilah Zabaneh, Alana Cavadino, Chris Finan, Andrew Wong, Antoinette Amuzu, Ken Ong, Tom Gaunt, Michael V Holmes, Helen Warren, Daniel I Swerdlow, Teri-Louise Davies, Fotios Drenos, Jackie Cooper, Reecha Sofat, Mark Caulfield, Shah Ebrahim, Debbie A Lawlor, Philippa J Talmud, Steve E Humphries, Christine Power, Elina Hypponen, Marcus Richards, Rebecca Hardy, Diana Kuh, Nicholas Wareham, Claudia Langenberg, Yoav Ben-Shlomo, Ian N Day, Peter Whincup, Richard Morris, Mark W J Strachan, Jacqueline Price, Meena Kumari, Mika Kivimaki, Vincent Plagnol, Frank Dudbridge, John C Whittaker, Juan P Casas, Aroon D Hingorani, UCLEB Consortium

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71345 (2013)

Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding

Externí odkaz: https://doaj.org/article/7c7b63b1f59a43a7b092f3deed11c53b

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Autor: Dan Rujescu, Vidar M. Steen, Eva Krapohl, Aarno Palotie, Elisabeth Widen, Ingrid Melle, Patrick Sullivan, Katrina L. Grasby, Stephan Ripke, Anke R. Hammerschlag, Christiaan de Leeuw, Panos Bitsios, Nikos C. Stefanis, Tonya White, Gail Davies, Ahmad R. Hariri, Philip R. Jansen, Peter B. Barr, John M. Starr, Max Lam, Ian J. Deary, Sara Hägg, Dimitrios Avramopoulos, Bettina Konte, Anil K. Malhotra, Delilah Zabaneh, Kjetil Sundet, Tinca J. C. Polderman, Ornit Chiba-Falek, Jakob Kaminski, Danielle M. Dick, Andrea Christoforou, Jin Yu, Gunter Schumann, Matthew A. Scult, Anna C. Need, Jens Hjerling-Leffler, Gonçalo R. Abecasis, Kenneth S. Kendler, Todd Lencz, Dwight Dickinson, Bradley T. Webb, Elizabeth T. Cirulli, Stephanie Le Hellard, Gerome Breen, Astri J. Lundervold, Hannah Young, Erin Burke Quinlan, William Ollier, Nikolaos Smyrnis, Emily Drabant Conley, Danielle Posthuma, Sten Linnarsson, Aristotle N. Voineskos, Edythe D. London, Pamela DeRosse, Russell A. Poldrack, Jonathan R. I. Coleman, Jeanne E. Savage, Sarah E. Medland, Ana B. Muñoz-Manchado, Richard E. Straub, Robert Plomin, Ida K. Karlsson, Nathan G. Skene, Dan E. Arking, Birgit Debrabant, Joey W. Trampush, Matthew C. Keller, Mats Nagel, Gary Donohoe, Chandra A. Reynolds, Panos Roussos, Lene Christiansen, Ivar Reinvang, Ole A. Andreassen, Antony Payton, Robert Karlsson, Margaret J. Wright, Deborah C. Koltai, Jari Lahti, Andreas Heinz, Tyrone D. Cannon, Eliza Congdon, Olav B. Smeland, Stella G. Giakoumaki, Marianne Nygaard, Julien Bryois, M. Arfan Ikram, Nancy L. Pedersen, Katri Räikkönen, Daniel R. Weinberger, Neil Pendleton, Swapnil Awasthi, Sven Stringer, Nelson A. Freimer, Aiden Corvin, Kyoko Watanabe, David C. Glahn, Henning Tiemeier, Grant W. Montgomery, Narelle K. Hansell, Robert M. Bilder, Katherine E. Burdick, Srdjan Djurovic, David C. Liewald, Sophie van der Sluis, Thomas Espeseth, Scott I. Vrieze, Fred W. Sabb, Nicholas G. Martin, Michael Gill, Emma Knowles, Derek W. Morris, Alex Hatzimanolis, Ina Giegling, Johan G. Eriksson

Publikováno v: Nature Genetics, 50(7), 912-+. Nature Publishing Group
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, De Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, Derosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, Van Der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6
Nature Genetics, 50(7), 912-919. Nature Publishing Group
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, de Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, DeRosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-Leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, van der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, 0, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, de Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, DeRosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-Leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, van der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, de Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, DeRosse, P, Dickinson, D, Djurovic, S, Christiansen, L & Debrabant, B 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, pp. 912–919 . https://doi.org/10.1038/s41588-018-0152-6
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, De Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, Derosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-Leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, Van Der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6

Intelligence is highly heritable 1 and a major determinant of human health and well-being 2 . Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence 3-7 , but much about its genetic underpinnings remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01a163caf208bcb9031ce88be260d18
https://doi.org/10.1038/s41588-018-0152-6

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Autor: Gerome Breen, Suzanne Sniekers, Neil Pendleton, Robert Plomin, Antony Payton, Magnus Johannesson, Anke R. Hammerschlag, Sven Stringer, Philipp Koellinger, Matt McGue, David Cesarini, Najaf Amin, Christopher F. Chabris, Delilah Zabaneh, Cornelia M. van Duijn, Cornelius A. Rietveld, Aysu Okbay, Jonathan R. I. Coleman, Michael B. Miller, Danielle Posthuma, Eva Krapohl, Erdogan Taskesen, William G. Iacono, Kyoko Watanabe, Philip R. Jansen, Patrik K. E. Magnusson, William E R Ollier, James J. Lee, Henning Tiemeier, M. Arfan Ikram

Publikováno v: Nature Genetics, 49(7), 1107-1112. Nature Publishing Group
Sniekers, S, Stringer, S, Watanabe, K, Jansen, P R, Coleman, J R I, Krapohl, E, Taskesen, E, Hammerschlag, A R, Okbay, A, Zabaneh, D, Amin, N, Breen, G, Cesarini, D, Chabris, C F, Iacono, W G, Ikram, M A, Johannesson, M, Koellinger, P, Lee, J J, Magnusson, P K E, McGue, M, Miller, M B, Ollier, W E R, Payton, A, Pendleton, N, Plomin, R, Rietveld, C A, Tiemeier, H, Van Duijn, C M & Posthuma, D 2017, ' Genome-wide association meta-A nalysis of 78,308 individuals identifies new loci and genes influencing human intelligence ', Nature Genetics, vol. 49, no. 7, pp. 1107-1112 . https://doi.org/10.1038/ng.3869
Nature Genetics
Sniekers, S, Stringer, S, Watanabe, K, Jansen, P R, Coleman, J R I, Krapohl, E, Taskesen, E, Hammerschlag, A R, Okbay, A, Zabaneh, D, Amin, N, Breen, G, Cesarini, D, Chabris, C F, Iacono, W G, Ikram, M A, Johannesson, M, Koellinger, P, Lee, J J, Magnusson, P K E, McGue, M, Miller, M B, Ollier, W E R, Payton, A, Pendleton, N, Plomin, R, Rietveld, C A, Tiemeier, H, van Duijn, C M & Posthuma, D 2017, ' Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence ', Nature Genetics, vol. 49, no. 7, pp. 1107-1112 . https://doi.org/10.1038/ng.3869
Nature genetics
Nature genetics, 49(7), 1107-1112. Nature Publishing Group
Sniekers, S, Stringer, S, Watanabe, K, Jansen, P R, Coleman, J, Krapohl, E, Taskesen, E, Hammerschlag, A R, Okbay, A, Zabaneh, D, Amin, N, Breen, G, Cesarini, D, Chabris, C F, Iacono, W G, Ikram, M A, Johannesson, M, Koellinger, P, Lee, J J, Magnusson, P K E, McGue, M, Miller, M B, Ollier, W E R, Payton, A, Pendleton, N, Plomin, R, Rietveld, C A, Tiemeier, H, van Duijn, C M & Posthuma, D 2017, ' Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence ', Nature Genetics, vol. 49, no. 7, pp. 1107–1112 . https://doi.org/10.1038/ng.3869

Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547e1e3e477a5461cb76752c5e210a0e
http://www.scopus.com/inward/record.url?scp=85020899420&partnerID=8YFLogxK

Cystatin C and Cardiovascular Disease

Autor: Heribert Schunkert, Wolfgang Koenig, Jessica van Setten, Meena Kumari, Johan Ärnlöv, J. Wouter Jukema, Vinicius Tragante, Alanna C. Morrison, Bradford B. Worrall, Brendan J. Keating, Alexander Teumer, Vilmantas Giedraitis, Tom Wilsgaard, Nilesh J. Samani, Barbara Thorand, Patricia B. Munroe, Rainer Malik, Melanie Waldenberger, Christopher P. Nelson, Sebastian E. Baumeister, Aroon D. Hingorani, Stéphanie Debette, Tove Fall, Patrik K. E. Magnusson, Nora Franceschini, Anders Larsson, Andrew P. Morris, Folkert W. Asselbergs, Maryam Kavousi, Oscar H. Franco, Jeanette Erdmann, Jonathan Marchini, Mika Kivimäki, Ivana Išgum, Fotios Drenos, N. Charlotte Onland-Moret, Bjørn Odvar Eriksen, Aicha Soumare, Christopher J. O'Donnell, Ingrid Toft, Paul I.W. de Bakker, Johannes Arpegård, Jacqueline de Graaf, Abbas Dehghan, Delilah Zabaneh, Michael V. Holmes, Yvonne T. van der Schouw, Alexander P. Reiner, André G. Uitterlinden, Christa Meisinger, Janine F. Felix, Erik Ingelsson, Lars Lind, Martin Dichgans, Marcus Dörr, Albert Hofman, Sanaz Sedaghat, Lambertus A. Kiemeney, Joshua C. Bis, Jens Baumert, Tessel E. Galesloot, Hester M. den Ruijter, Gerard Pasterkamp, Annette Peters, Naveed Sattar, Nancy L. Pedersen, Pim van der Harst, Stella Trompet, Per Svensson, Riyaz S. Patel, Philippe Amouyel, Sander W. van der Laan

Publikováno v: Journal of the American College of Cardiology. 68:934-945

BACKGROUND Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349129f2fcbb5bbfe6775dc918b081b3
https://doi.org/10.1016/j.jacc.2016.05.092