Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Delia Zafra"'
Autor:
Ana Isabel Fernández-Mariño, Pilar Cidad, Delia Zafra, Laura Nocito, Jorge Domínguez, Aida Oliván-Viguera, Ralf Köhler, José R López-López, María Teresa Pérez-García, Miguel Ángel Valverde, Joan J Guinovart, José M Fernández-Fernández
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118148 (2015)
Despite the substantial knowledge on the antidiabetic, antiobesity and antihypertensive actions of tungstate, information on its primary target/s is scarce. Tungstate activates both the ERK1/2 pathway and the vascular voltage- and Ca2+-dependent larg
Externí odkaz:
https://doaj.org/article/25b697aef0f54fd5af54d19183c72a86
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42305 (2012)
Oral administration of sodium tungstate has shown hyperglycemia-reducing activity in several animal models of diabetes. We present new insights into the mechanism of action of tungstate.We studied protein expression and phosphorylation in the liver o
Externí odkaz:
https://doaj.org/article/a878bf89808e47c9b367d5443a819e3e
Autor:
Delia Zafra, Joan J. Guinovart, Jordi Duran, Iliana López-Soldado, Joaquim Calbó, Anna Adrover
Publikováno v:
Diabetes. 64:796-807
We generated mice that overexpress protein targeting to glycogen (PTG) in the liver (PTGOE), which results in an increase in liver glycogen. When fed a high-fat diet (HFD), these animals reduced their food intake. The resulting effect was a lower bod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498c0af2bd8d662b2f4c843855c383ba
https://doi.org/10.2337/db14-0728
https://doi.org/10.2337/db14-0728
Autor:
Ainhoa Garcia, Sandra A. Rebuffat, Delia Zafra, Deborah J. Burks, Rosa Gasa, Susana G. Kalko, Joana Moitinho Oliveira, Joan J. Guinovart, Ramon Gomis
Publikováno v:
AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 2014, 306 (1), pp.E36-E47. ⟨10.1152/ajpendo.00409.2013⟩
AJP-Endocrinology and Metabolism, American Physiological Society, 2014, 306 (1), pp.E36-E47. ⟨10.1152/ajpendo.00409.2013⟩
Pancreatic β-cells play a central role in type 2 diabetes (T2D) development, which is characterized by the progressive decline of the functional β-cell mass that is associated mainly with increased β-cell apoptosis. Thus, understanding how to enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292ded0aeed91d873cfdb0ecc01cfb63
https://doi.org/10.1152/ajpendo.00409.2013
https://doi.org/10.1152/ajpendo.00409.2013
Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteins
Publikováno v:
FEBS Letters. 587:291-296
Tungstate treatment ameliorates experimental diabetes by increasing liver glycogen deposition through an as yet unidentified mechanism. The signalling mechanism of tungstate was studied in CHOIR cells and primary cultured hepatocytes. This compound e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ceff4900f7274feb5982cc17ea905aa
https://doi.org/10.1016/j.febslet.2012.11.034
https://doi.org/10.1016/j.febslet.2012.11.034
Autor:
Aida Oliván-Viguera, Delia Zafra, Miguel A. Valverde, Ralf Köhler, Laura Nocito, Jorge Domínguez, José M. Fernández-Fernández, Pilar Cidad, M. T. Pérez-García, Ana I. Fernández-Mariño, Joan J. Guinovart, José R. López-López
Publikováno v:
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
instname
UVaDOC. Repositorio Documental de la Universidad de Valladolid
PLoS ONE, Vol 10, Iss 2, p e0118148 (2015)
Recercat. Dipósit de la Recerca de Catalunya
Digital.CSIC. Repositorio Institucional del CSIC
instname
UVaDOC. Repositorio Documental de la Universidad de Valladolid
PLoS ONE, Vol 10, Iss 2, p e0118148 (2015)
Recercat. Dipósit de la Recerca de Catalunya
Producción Científica
Despite the substantial knowledge on the antidiabetic, antiobesity and antihypertensive actions of tungstate, information on its primary target/s is scarce. Tungstate activates both the ERK1/2 pathway and the vascular vol
Despite the substantial knowledge on the antidiabetic, antiobesity and antihypertensive actions of tungstate, information on its primary target/s is scarce. Tungstate activates both the ERK1/2 pathway and the vascular vol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a00a8d215092e10ab02593dc0a8cc5
http://hdl.handle.net/10230/25625
http://hdl.handle.net/10230/25625
Autor:
Francesc Alameda, Jorge Domínguez, Maria Dolores Ledesma, Carlos G. Dotti, Manel G. Medina, Delia Zafra, Pilar Navarro, Miguel Medina
Publikováno v:
The EMBO Journal. 24:1706-1716
Tissue plasminogen activator (tPA) is the main activator of plasminogen into plasmin in the brain where it may have beneficial roles but also neurotoxic effects that could be plasmin dependent or not. Little is known about the substrates and pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ebdcd67edc323b7295439a4df65ec1
https://doi.org/10.1038/sj.emboj.7600650
https://doi.org/10.1038/sj.emboj.7600650
Autor:
Delia Zafra, Joan J. Guinovart, Ciro Mercurio, Rosario Perona, Albert Barberà, Isabel Sánchez-Pérez, Jorge Domínguez, Martine Caron, Mª Carmen Muñoz, Susanna Baqué, Ramon Gomis
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Sodium tungstate is a powerful antidiabetic agent when administered orally. In primary cultured hepatocytes, tungstate showed insulin-like actions, which led to an increase in glycogen synthesis and accumulation. However, this compound did not signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30203c07493d9001f37ac8ddd9bfd6a
https://doi.org/10.1074/jbc.m308334200
https://doi.org/10.1074/jbc.m308334200
Autor:
Susana Ros, Delia Zafra, Stephen Forrow, Jordi Valles-Ortega, Joan J. Guinovart, Mar García-Rocha, Jorge Domínguez, Joaquim Calbó
Publikováno v:
The Journal of biological chemistry. 285(48)
In this study, we tested the efficacy of increasing liver glycogen synthase to improve blood glucose homeostasis. The overexpression of wild-type liver glycogen synthase in rats had no effect on blood glucose homeostasis in either the fed or the fast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c0380343e7e0818fea1fe315521f92
https://pubmed.ncbi.nlm.nih.gov/20841354
https://pubmed.ncbi.nlm.nih.gov/20841354
Autor:
Jesús Avila, Jorge Dominguez, Delia Zafra, Ramon Gomis, Helena Corominola, Alberto Gómez-Ramos, Joan J. Guinovart
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
One of the main pathological characteristics of Alzheimers disease is the presence in the brain of the patients of an aberrant structure, the paired helical filaments, composed of hyperphosphorylated tau. The level of tau phosphorylation has been cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4555d6309c89ed2032e85f4979fa4b0
http://hdl.handle.net/10261/252375
http://hdl.handle.net/10261/252375