Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance

Autor: Jana Van Dycke, Michela Puxeddu, Giuseppe La Regina, Eloise Mastrangelo, Delia Tarantino, Jasper Rymenants, Jessica Sebastiani, Marianna Nalli, Jelle Matthijnssens, Johan Neyts, Romano Silvestri, Joana Rocha-Pereira

Publikováno v: Pharmaceuticals, Vol 14, Iss 10, p 1006 (2021)

Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting in ~219,000 deaths annually and a societal cost of ~USD60 billion. There are no antivirals or vaccines available to treat and/or prevent HuNoV. In this study, we

Externí odkaz: https://doaj.org/article/67a5e148492f472c90bbc00a58b6c0e3

Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage

Autor: Romano Silvestri, Joachim J. Bugert, Eloise Mastrangelo, Jin-Ching Lee, Giuseppe La Regina, Juliane Nolte, Marianna Nalli, Benno Schreiner, Yu-Hsuan Wu, Antonio Coluccia, Tasneem Elamin, Michela Puxeddu, Frank Schwarze, Delia Tarantino, Chih-Ku Wei

Publikováno v: ACS Med Chem Lett
ACS medicinal chemistry letters (2020). doi:10.1021/acsmedchemlett.9b00405
info:cnr-pdr/source/autori:Antonio Coluccia, Michela Puxeddu, Marianna Nalli, Chih-Ku Wei, Yu-Hsuan Wu, Eloise Mastrangelo, Tasneem Elamin, Delia Tarantino, Joachim Jakob Bugert, Benno Schreiner, Juliane Nolte, Frank Schwarze, Giuseppe La Regina, Jin-Ching Lee, Romano Silvestri/titolo:Discovery of Zika Virus NS2B%2FNS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage/doi:10.1021%2Facsmedchemlett.9b00405/rivista:ACS medicinal chemistry letters/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume

[Image: see text] Zika virus (ZIKV) infection, which initially was endemic only in Africa and Asia, is rapidly spreading throughout Europe, Oceania, and the Americas. Although there have been enormous efforts, there is still no approved drug to treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4825c619116750951a5c9048dd8ef039
https://europepmc.org/articles/PMC7549096/

Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.

Autor: Romina Croci, Margherita Pezzullo, Delia Tarantino, Mario Milani, Shwu-Chen Tsay, Radhakrishnan Sureshbabu, Yi-Jin Tsai, Eloise Mastrangelo, Jacques Rohayem, Martino Bolognesi, Jih Ru Hwu

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91765 (2014)

Noroviruses (NV) are +ssRNA viruses responsible for severe gastroenteritis; no effective vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp). Despite sig

Externí odkaz: https://doaj.org/article/3bb15fd0144147289af16ceed90b73e6

Ligand Binding in Allosteric Flavoproteins: Part 2. Quantitative Analysis of the Redox-Dependent Interaction of the Apoptosis-Inducing Factor (AIF) with Its Protein Partner

Autor: Delia Tarantino, Paolo Cocomazzi, Alessandro Aliverti, Eloise Mastrangelo

Publikováno v: Methods in Molecular Biology ISBN: 9781071612859

To perform their action usually flavoproteins interact transiently with a variety of molecular partners, whose binding is reciprocally affected and often controlled by the redox state of the bound flavin cofactor. As a case study, here we describe an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13899dbea7c18e2dac69a4483d30e528
https://doi.org/10.1007/978-1-0716-1286-6_12

Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions

Autor: Rolando Cannalire, Mario Milani, Giuseppe Manfroni, Géraldine Piorkowski, Serena Massari, Violetta Cecchetti, Maria Letizia Barreca, Tommaso Felicetti, Gilles Querat, Delia Tarantino, Tea Carletti, Alessandro Marcello, Stefano Sabatini, Oriana Tabarrini, Eloise Mastrangelo

Publikováno v: Antiviral Research
Antiviral Research, 2019, 167, pp.6-12. ⟨10.1016/j.antiviral.2019.03.004⟩
Antiviral research
167 (2019): 6–12. doi:10.1016/j.antiviral.2019.03.004
info:cnr-pdr/source/autori:Cannalire R, Tarantino D, Piorkowski G, Carletti T, Massari S, Felicetti T, Barreca ML, Sabatini S, Tabarrini O, Marcello A, Milani M, Cecchetti V, Mastrangelo E, Manfroni G, Querat G/titolo:Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions/doi:10.1016%2Fj.antiviral.2019.03.004/rivista:Antiviral research (Print)/anno:2019/pagina_da:6/pagina_a:12/intervallo_pagine:6–12/volume:167
Antiviral Research, Elsevier Masson, 2019, 167, pp.6-12. ⟨10.1016/j.antiviral.2019.03.004⟩

We report the design, synthesis, and biological evaluation of a class of 1H-pyrido[2,1-b][1,3]benzothiazol-1-ones originated from compound 1, previously identified as anti-flavivirus agent. Some of the new compounds showed activity in low ?M range wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726cb8d92b0c4847bc9dc7a3cac2b6c2
http://hdl.handle.net/11588/764687