Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Delia Li"'
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTHost cell proteins (HCPs) are process-related impurities derived from the manufacturing of recombinant biotherapeutics. Residual HCP in drug products, ranging from 1 to 100 ppm (ng HCP/mg product) or even below sub-ppm level, may affect produ
Externí odkaz:
https://doaj.org/article/273decb2ae694d2098838e32ef9d9bf5
Autor:
Feng Yang, Delia Li, Regina Kufer, Lance Cadang, Jennifer Zhang, Lu Dai, Jia Guo, Stefanie Wohlrab, Midori Greenwood-Goodwin, Amy Shen, Dana Duan, Hong Li, Inn H. Yuk
Publikováno v:
Analytical Chemistry. 94:723-731
Residual host cell proteins (HCPs) in the drug product can affect product quality, stability, and/or safety. In particular, highly active hydrolytic enzymes at sub-ppm levels can negatively impact the shelf life of drug products but are challenging t
Autor:
Ancuta Lupu, Silvia Fotea, Elena Jechel, Iuliana Magdalena Starcea, Ileana Ioniuc, Anton Knieling, Delia Lidia Salaru, Maria Oana Sasaran, Olga Cirstea, Neli Revenco, Cristina Maria Mihai, Vasile Valeriu Lupu, Alin Horatiu Nedelcu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Despite the early recognition of obesity as an epidemic with global implications, research on its pathogenesis and therapeutic approach is still on the rise. The literature of the 21st century records an excess weight found in up to 1/3 of children.
Externí odkaz:
https://doaj.org/article/d8254e98789245a18a9c4921df38da92
Publikováno v:
J Neurosci
Hearing loss is the biggest risk factor for tinnitus, and hearing-loss-related pathological changes in the auditory pathway have been hypothesized as the mechanism underlying tinnitus. However, due to the comorbidity of tinnitus and hearing loss, it
Publikováno v:
Therapeutic Antibodies ISBN: 9781071614495
A sensitive and reliable two-dimensional LC-MS/MS method is described, which detects low level (≥10 ppm) host cell proteins (HCPs) in monoclonal antibody (mAb) drug products. This method applies a high pH-low pH two-dimensional reversed phase (RP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::682d21ed08e0d7891102c71b6db9ea22
https://doi.org/10.1007/978-1-0716-1450-1_16
https://doi.org/10.1007/978-1-0716-1450-1_16
Autor:
Ancuta Lupu, Alin Horatiu Nedelcu, Paula Diana Budescu, Elena Jechel, Iuliana Magdalena Starcea, Otilia Elena Frasinariu, Ileana Ioniuc, Minerva Codruta Badescu, Delia Lidia Salaru, Dragos Munteanu, Ruxandra Russu, Radu Andy Sascau, Cristian Statescu, Vasile Valeriu Lupu
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Infective endocarditis is a rare disease in children. The etiology is mainly bacterial. However, viral infective endocarditis, possibly related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has also been reported. The pathophysiolo
Externí odkaz:
https://doaj.org/article/1fbe02dd0d8f44d0a7c5aa3aee9088df
Autor:
Ancuta Lupu, Maria Oana Sasaran, Elena Jechel, Alice Azoicai, Monica Mihaela Alexoae, Iuliana Magdalena Starcea, Adriana Mocanu, Alin Horatiu Nedelcu, Anton Knieling, Delia Lidia Salaru, Stefan Lucian Burlea, Vasile Valeriu Lupu, Ileana Ioniuc
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Connective tissue represents the support matrix and the connection between tissues and organs. In its composition, collagen, the major structural protein, is the main component of the skin, bones, tendons and ligaments. Especially at the pediatric ag
Externí odkaz:
https://doaj.org/article/b1c3b5ec0d7043cb833689b792afcd4d
Autor:
Alice Azoicai, Ancuta Lupu, Monica Mihaela Alexoae, Iuliana Magdalena Starcea, Adriana Mocanu, Vasile Valeriu Lupu, Elena Cristina Mitrofan, Alin Horatiu Nedelcu, Razvan Tudor Tepordei, Dragos Munteanu, Costica Mitrofan, Delia Lidia Salaru, Ileana Ioniuc
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
The present treatments for bronchiectasis, which is defined by pathological dilatation of the airways, are confined to symptom relief and minimizing exacerbations. The condition is becoming more common worldwide. Since the disease’s pathophysiology
Externí odkaz:
https://doaj.org/article/64c4e64137754d28b0dcdad7c4798db0
Autor:
Alice Nicoleta Azoicai, Ancuta Lupu, Laura Mihaela Trandafir, Monica Mihaela Alexoae, Mirabela Alecsa, Iuliana Magdalena Starcea, Magdalena Cuciureanu, Anton Knieling, Delia Lidia Salaru, Elena Hanganu, Adriana Mocanu, Vasile Valeriu Lupu, Ileana Ioniuc
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations of the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). In 1949, it's been identified as a monogenic disease and was thought to primarily affect i
Externí odkaz:
https://doaj.org/article/b7f474b2c6f746eeb160816c6a0e8708
Autor:
Alin Dumitru Ciubotaru, Laura Stoica, Liliana Georgeta Foia, Vasilica Toma, Delia Lidia Salaru, Carmen-Ecaterina Leferman, Bogdan Alexandru Stoica, Cristina-Mihaela Ghiciuc
Publikováno v:
Romanian Journal of Oral Rehabilitation, Vol 15, Iss 4, Pp 417-425 (2023)
Thiol-containing compounds, renowned as potent antioxidants, encompass various drugs and naturally occurring biological substances prevalent within the body. Aim of the study The study aimed to determine the level of inhibition of the photochemilumin
Externí odkaz:
https://doaj.org/article/7028b6602f6e48dd99b5df9ea42af7be