Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Delia I, Fernández"'
Autor:
Delia I. Fernández, Sara Troitiño, Vladimír Sobota, Bibian M. E. Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J. E. Kuijpers, Johan W. M. Heemskerk
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin. This is reflected in the different platel
Externí odkaz:
https://doaj.org/article/e0e4cce4e1b944baa6e8d33649209870
Autor:
Jingnan Huang, Delia I. Fernández, Jinmi Zou, Xueqing Wang, Johan W.M. Heemskerk, Ángel García
Publikováno v:
Bleeding, Thrombosis and Vascular Biology, Vol 2, Iss 3 (2023)
The platelet collagen receptor glycoprotein VI (GPVI) signals to activation of phospholipase Cγ2 (PLCγ2) and phosphoinositide 3-kinases (PI3K), causing platelet activation and aggregation. The non-receptor Src homology tyrosine phosphatases Shp1/2
Externí odkaz:
https://doaj.org/article/980a26f87a6e4e26afb6e9b5ee35830f
Publikováno v:
Platelets, Vol 32, Iss 7, Pp 863-871 (2021)
Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP), sign
Externí odkaz:
https://doaj.org/article/74671a565b0947cfad72e0c250d58249
Autor:
Delia I. Fernández, Isabella Provenzale, Hilaire Y.F. Cheung, Jan van Groningen, Bibian M.E. Tullemans, Alicia Veninga, Joanne L. Dunster, Saman Honarnejad, Helma van den Hurk, Marijke J.E. Kuijpers, Johan W.M. Heemskerk
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103718- (2022)
Summary: Antiplatelet drugs targeting G-protein-coupled receptors (GPCRs), used for the secondary prevention of arterial thrombosis, coincide with an increased bleeding risk. Targeting ITAM-linked receptors, such as the collagen receptor glycoprotein
Externí odkaz:
https://doaj.org/article/41f61631ed79476488c1835c6a7c8eef
Autor:
Jingnan Huang, Natalie J. Jooss, Delia I. Fernández, Albert Sickmann, Ángel García, Kanin Wichapong, Ingrid Dijkgraaf, Johan W. M. Heemskerk
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8688
International journal of molecular sciences, 23(15):8688. Multidisciplinary Digital Publishing Institute (MDPI)
International journal of molecular sciences, 23(15):8688. Multidisciplinary Digital Publishing Institute (MDPI)
Glycoprotein (GP)VI and integrin αIIbβ3 are key signaling receptors in collagen-dependent platelet aggregation and in arterial thrombus formation under shear. The multiple downstream signaling pathways are still poorly understood. Here, we focused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f88132095a0db6379e76aaf94d2e22
https://pubmed.ncbi.nlm.nih.gov/35955827
https://pubmed.ncbi.nlm.nih.gov/35955827
Autor:
Delia I, Fernández, Isabella, Provenzale, Hilaire Y F, Cheung, Jan, van Groningen, Bibian M E, Tullemans, Alicia, Veninga, Joanne L, Dunster, Saman, Honarnejad, Helma, van den Hurk, Marijke J E, Kuijpers, Johan W M, Heemskerk
Publikováno v:
iScience
Summary Antiplatelet drugs targeting G-protein-coupled receptors (GPCRs), used for the secondary prevention of arterial thrombosis, coincide with an increased bleeding risk. Targeting ITAM-linked receptors, such as the collagen receptor glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f97c2fe61bab3374cc750d4a5247af7c
https://pubmed.ncbi.nlm.nih.gov/35072010
https://pubmed.ncbi.nlm.nih.gov/35072010
Autor:
Johana Hrdinova, Delia I. Fernández, Bogac Ercig, Bibian M. E. Tullemans, Dennis P. L. Suylen, Stijn M. Agten, Kerstin Jurk, Tilman M. Hackeng, Karen Vanhoorelbeke, Jan Voorberg, Chris P. M. Reutelingsperger, Kanin Wichapong, Johan W. M. Heemskerk, Gerry A. F. Nicolaes
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 4; Pages: 2046
International journal of molecular sciences, 23(4):2046. Multidisciplinary Digital Publishing Institute (MDPI)
International journal of molecular sciences, 23(4):2046. Multidisciplinary Digital Publishing Institute (MDPI)
The plasmatic von Willebrand factor (VWF) circulates in a compact form unable to bind platelets. Upon shear stress, the VWF A1 domain is exposed, allowing VWF-binding to platelet glycoprotein Ib-V-IX (GPIbα chain). For a better understanding of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9683fcb46ca54dc3128754624194a6e5
https://doi.org/10.3390/ijms23042046
https://doi.org/10.3390/ijms23042046