Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Delia C. Tang"'
Autor:
Griffin P. Rodgers, Stephen J. Chanock, Delia C. Tang, Sharon A. Savage, Seth I. Heller, Graham R. Serjeant, James G. Taylor Vi, Susan F. Leitman
Publikováno v:
Blood. 100:4303-4309
Stroke is a major cause of morbidity and mortality in sickle cell (SS) disease. Genetic risk factors have been postulated to contribute to this clinical outcome. The human genome project has substantially increased the catalog of variations in genes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1530a278845aec991436160d329b76e
https://doi.org/10.1182/blood-2001-12-0306
https://doi.org/10.1182/blood-2001-12-0306
Autor:
Griffin P. Rodgers, Kyung Chin, Eitan Fibach, Wenli Liu, Delia C. Tang, Min Wang, Jianqion G. Zhu
Publikováno v:
British Journal of Haematology. 119:1098-1105
Summary. Hydroxyurea (HU) has been shown to increase the proportion of fetal haemoglobin (HbF) in most sickle cell patients. A low-dosage regimen increased total haemoglobin (Hb) levels in some thalassaemia intermedia patients by preferentially incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03927a79c25efddb648c1410be0b4868
https://doi.org/10.1046/j.1365-2141.2002.03958.x
https://doi.org/10.1046/j.1365-2141.2002.03958.x
Publikováno v:
British Journal of Haematology. 118:847-857
Summary. We examined the influence of cytokines on erythroid- and myeloid-lineage development of AC133+ cells during primary and secondary cultures. Cells cultured for 14 d in liquid medium containing erythropoietin (EPO) were amplified 831-fold with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb7c767b79a44abb6c77f69654f36d45
https://doi.org/10.1046/j.1365-2141.2002.03638.x
https://doi.org/10.1046/j.1365-2141.2002.03638.x
Publikováno v:
Journal of Laboratory and Clinical Medicine. 137:290-295
The alpha-thalassemias are common genetic disorders that arise from reduced synthesis of the alpha-globin chains. At present, large-scale carrier screening and clinically valuable antenatal detection programs have not been established for the congeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1f2c68a6e5d8fe5be310bc4e096d1b
https://doi.org/10.1067/mlc.2001.113947
https://doi.org/10.1067/mlc.2001.113947
Autor:
Robert P. Hirsch, Griffin P. Rodgers, Kye Hyun Kim, M. Catherine Driscoll, Wenli Liu, Ron Prauner, Delia C. Tang
Publikováno v:
American Journal of Hematology. 68:164-169
Stroke is one of the most devastating complications of patients with sickle cell disease (SCD). Currently, there are no known molecular or genetic markers that can be used to assess the risk of stroke in this population. We have previously shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154d4b8bb59264f4f1a586efe2ab7235
https://doi.org/10.1002/ajh.1173
https://doi.org/10.1002/ajh.1173
Publikováno v:
Nucleic Acids Research. 28:2823-2830
The molecular mechanisms which govern the develop-mental specificity of human beta-globin gene transcription have been studied in K562 cells, a human eyrthroleukemia line that expresses minimal beta-globin. Protein-binding analysis reveals that the 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c543289a5fd6d043b47a5887fcbc48ca
https://doi.org/10.1093/nar/28.14.2823
https://doi.org/10.1093/nar/28.14.2823
Autor:
Griffin P. Rodgers, Delia C. Tang
Publikováno v:
British Journal of Haematology. 103:835-838
Restoration of the CCAAT box or insertion of an erythroid Kruppel-like factor (EKLF) binding site in the delta promoter activates its expression in several erythroid cell lines. We extended these studies using a novel primary human adult erythroid ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a195cc6a03942bc4f5a3608ad2d0786
https://doi.org/10.1046/j.1365-2141.1998.01052.x
https://doi.org/10.1046/j.1365-2141.1998.01052.x
Publikováno v:
Blood. 90:421-427
Hemoglobin A2 (HbA2 ), which contains δ-globin as its non–α-globin, represents a minor fraction of the Hb found in normal adults. It has been shown recently that HbA2 is as potent as HbF in inhibiting intracellular deoxy-HbS polymerization, and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5d0d411ecbf7ae87ae8ff0fecbe7f1d
https://doi.org/10.1182/blood.v90.1.421.421_421_427
https://doi.org/10.1182/blood.v90.1.421.421_421_427
Publikováno v:
Blood. 90:421-427
Hemoglobin A2 (HbA2 ), which contains δ-globin as its non–α-globin, represents a minor fraction of the Hb found in normal adults. It has been shown recently that HbA2 is as potent as HbF in inhibiting intracellular deoxy-HbS polymerization, and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74654a1e9552960989e7d09b2bf7545b
https://doi.org/10.1182/blood.v90.1.421
https://doi.org/10.1182/blood.v90.1.421
Publikováno v:
Cell research. 16(12)
We utilized a unique culture system to analyze the expression patterns of gene, protein, and cell surface antigen, and the biological process of the related genes in erythroid and myeloid differentiation and switching of hematopoietic stem cells (HSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c612fc2f9a2853c73767ed42219805d9
https://pubmed.ncbi.nlm.nih.gov/17146449
https://pubmed.ncbi.nlm.nih.gov/17146449