Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Delia Belelli"'
Neurosteroid Modulation of Synaptic and Extrasynaptic GABAA Receptors of the Mouse Nucleus Accumbens
Autor:
Scott J. Mitchell, Grant D. Phillips, Becks Tench, Yunkai Li, Delia Belelli, Stephen J. Martin, Jerome D. Swinny, Louise Kelly, John R. Atack, Michael Paradowski, Jeremy J. Lambert
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 460 (2024)
The recent approval of formulations of the endogenous neurosteroid allopregnanolone (brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat postpartum depression (PPD) has encouraged further research to elucidate why these
Externí odkaz:
https://doaj.org/article/e9f4ea689ff047bdb0ce891c119b69a6
Autor:
David J. Nutt, Robin J. Tyacke, Meg Spriggs, Vanessa Jacoby, Alan D. Borthwick, Delia Belelli
Publikováno v:
Nutrients, Vol 14, Iss 18, p 3761 (2022)
The consumption of alcohol is associated with well-known health harms and many governments worldwide are actively engaged in devising approaches to reduce them. To this end, a common proposed strategy aims at reducing alcohol consumption. This approa
Externí odkaz:
https://doaj.org/article/29bf56563d5540eab844afad611918b0
Publikováno v:
Neurobiology of Stress, Vol 12, Iss , Pp - (2020)
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR). These reports were followed by the discovery that
Externí odkaz:
https://doaj.org/article/8b28a0f5a73447948d30996d5d43b0e6
Autor:
Werner Sieghart, Uwe Rudolph, John A. Peters, Richard Olsen, Bernhard Luscher, Jeremy J. Lambert, Tim G. Hales, Delia Belelli
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The GABAA receptor is a ligand-gated ion channel of the Cys-loop family that includes the nicotinic acetylcholine, 5-HT3 and strychnine-sensitive glycine receptors. GABAA receptor-mediated inhibition within the CNS occurs by fast synaptic transmissio
Autor:
Jessica L. Bolton, Annabel K. Short, Shivashankar Othy, Cassandra L. Kooiker, Manlin Shao, Benjamin G. Gunn, Jaclyn Beck, Xinglong Bai, Stephanie M. Law, Julie C. Savage, Jeremy J. Lambert, Delia Belelli, Marie-Ève Tremblay, Michael D. Cahalan, Tallie Z. Baram
Publikováno v:
Alcohol. 109:87-88
Autor:
Jessica L. Bolton, Annabel K. Short, Shivashankar Othy, Cassandra L. Kooiker, Manlin Shao, Benjamin G. Gunn, Jaclyn Beck, Xinglong Bai, Stephanie M. Law, Julie C. Savage, Jeremy J. Lambert, Delia Belelli, Marie-Ève Tremblay, Michael D. Cahalan, Tallie Z. Baram
Publikováno v:
Cell reports. 38(13)
Several mental illnesses, characterized by aberrant stress reactivity, often arise after early-life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit maturation, provoking these enduring vulnerabilities. We find tha
Autor:
Bernhard Lüscher, John A. Peters, Delia Belelli, Jeremy J. Lambert, Tim G. Hales, Werner Sieghart, Richard B. Olsen, Uwe Rudolph
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
The GABAA receptor is a ligand-gated ion channel of the Cys-loop family that includes the nicotinic acetylcholine, 5-HT3 and strychnine-sensitive glycine receptors. GABAA receptor-mediated inhibition within the CNS occurs by fast synaptic transmissio
Publikováno v:
Journal of neuroendocrinologyREFERENCES. 34(2)
Studies in the 1980s revealed endogenous metabolites of progesterone and deoxycorticosterone to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAA R). The discovery that such steroids are locally synthesised in
Autor:
Jeremy J. Lambert, Marie-Ève Tremblay, Cassandra L. Kooiker, Benjamin G. Gunn, Jaclyn Beck, Stephanie M. Law, Jessica L. Bolton, Manlin Shao, Delia Belelli, Xinglong Bai, Julie C. Savage, Michael D. Cahalan, Annabel K. Short, Tallie Z. Baram, Shivashankar Othy
The developmental origins of stress-related mental illnesses are well-established, and early-life stress/adversity (ELA) is an important risk factor. However, it is unclear how ELA impacts the maturation of salient brain circuits, provoking enduring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78f096e313a614e8acfe413c63152088
https://doi.org/10.1101/2021.07.21.453252
https://doi.org/10.1101/2021.07.21.453252