Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

Autor: Lawrenson, K, Kar, S, McCue, K, Kuchenbaeker, K, Michailidou, K, Tyrer, J, Beesley, J, Ramus, SJ, Li, Q, Delgado, MK, Lee, JM, Aittomäki, K, Andrulis, IL, Anton-Culver, H, Arndt, V, Arun, BK, Arver, B, Bandera, EV, Barile, M, Barkardottir, RB, Barrowdale, D, Beckmann, MW, Benitez, J, Berchuck, A, Bisogna, M, Bjorge, L, Blomqvist, C, Blot, W, Bogdanova, N, Bojesen, A, Bojesen, SE, Bolla, MK, Bonanni, B, Børresen-Dale, A-L, Brauch, H, Brennan, P, Brenner, H, Bruinsma, F, Brunet, J, Buhari, SA, Burwinkel, B, Butzow, R, Buys, SS, Cai, Q, Caldes, T, Campbell, I, Canniotto, R, Chang-Claude, J, Chiquette, J, Choi, J-Y, Claes, KBM, GEMO Study Collaborators, Cook, LS, Cox, A, Cramer, DW, Cross, SS, Cybulski, C, Czene, K, Daly, MB, Damiola, F, Dansonka-Mieszkowska, A, Darabi, H, Dennis, J, Devilee, P, Diez, O, Doherty, JA, Domchek, SM, Dorfling, CM, Dörk, T, Dumont, M, Ehrencrona, H, Ejlertsen, B, Ellis, S, EMBRACE, Engel, C, Lee, E, Evans, DG, Fasching, PA, Feliubadalo, L, Figueroa, J, Flesch-Janys, D, Fletcher, O, Flyger, H, Foretova, L, Fostira, F, Foulkes, WD, Fridley, BL, Friedman, E, Frost, D, Gambino, G, Ganz, PA, Garber, J, García-Closas, M, Gentry-Maharaj, A, Ghoussaini, M, Giles, GG, Glasspool, R, Godwin, AK, Goldberg, MS, Goldgar, DE, González-Neira, A, Goode, EL, Goodman, MT, Greene, MH, Gronwald, J, Guénel, P, Haiman, CA, Hall, P, Hallberg, E, Hamann, U, Hansen, TVO, Harrington, PA, Hartman, M, Hassan, N, Healey, S, Hereditary Breast And Ovarian Cancer Research Group Netherlands (HEBON), Heitz, F, Herzog, J, Høgdall, E, Høgdall, CK, Hogervorst, FBL, Hollestelle, A, Hopper, JL, Hulick, PJ, Huzarski, T, Imyanitov, EN, KConFab Investigators, Australian Ovarian Cancer Study Group, Isaacs, C, Ito, H, Jakubowska, A, Janavicius, R, Jensen, A, John, EM, Johnson, N, Kabisch, M, Kang, D, Kapuscinski, M, Karlan, BY, Khan, S, Kiemeney, LA, Kjaer, SK, Knight, JA, Konstantopoulou, I, Kosma, V-M, Kristensen, V, Kupryjanczyk, J, Kwong, A, De La Hoya, M, Laitman, Y, Lambrechts, D, Le, N, De Leeneer, K, Lester, J, Levine, DA, Li, J, Lindblom, A, Long, J, Lophatananon, A, Loud, JT, Lu, K, Lubinski, J, Mannermaa, A, Manoukian, S, Le Marchand, L, Margolin, S, Marme, F, Massuger, LFAG, Matsuo, K, Mazoyer, S, McGuffog, L, McLean, C, McNeish, I, Meindl, A, Menon, U, Mensenkamp, AR, Milne, RL, Montagna, M, Moysich, KB, Muir, K, Mulligan, AM, Nathanson, KL, Ness, RB, Neuhausen, SL, Nevanlinna, H, Nord, S, Nussbaum, RL, Odunsi, K, Offit, K, Olah, E, Olopade, OI, Olson, JE, Olswold, C, O'Malley, D, Orlow, I, Orr, N, Osorio, A, Park, SK, Pearce, CL, Pejovic, T, Peterlongo, P, Pfeiler, G, Phelan, CM, Poole, EM, Pylkäs, K, Radice, P, Rantala, J, Rashid, MU, Rennert, G, Rhenius, V, Rhiem, K, Risch, HA, Rodriguez, G, Rossing, MA, Rudolph, A, Salvesen, HB, Sangrajrang, S, Sawyer, EJ, Schildkraut, JM, Schmidt, MK, Schmutzler, RK, Sellers, TA, Seynaeve, C, Shah, M, Shen, C-Y, Shu, X-O, Sieh, W, Singer, CF, Sinilnikova, OM, Slager, S, Song, H, Soucy, P, Southey, MC, Stenmark-Askmalm, M, Stoppa-Lyonnet, D, Sutter, C, Swerdlow, A, Tchatchou, S, Teixeira, MR, Teo, SH, Terry, KL, Terry, MB, Thomassen, M, Tibiletti, MG, Tihomirova, L, Tognazzo, S, Toland, AE, Tomlinson, I, Torres, D, Truong, T, Tseng, C-C, Tung, N, Tworoger, SS, Vachon, C, Van Den Ouweland, AMW, Van Doorn, HC, Van Rensburg, EJ, Van't Veer, LJ, Vanderstichele, A, Vergote, I, Vijai, J, Wang, Q, Wang-Gohrke, S, Weitzel, JN, Wentzensen, N, Whittemore, AS, Wildiers, H, Winqvist, R, Wu, AH, Yannoukakos, D, Yoon, S-Y, Yu, J-C, Zheng, W, Zheng, Y, Khanna, KK, Simard, J, Monteiro, AN, French, JD, Couch, FJ, Freedman, ML, Easton, DF, Dunning, AM, Pharoah, PD, Edwards, SL, Chenevix-Trench, G, Antoniou, AC, Gayther, SA

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e8cfb6f94d8473dc5b64257a4197819

Handheld Cellphone Use and Risky Driving in Adolescents.

Autor: McDonald CC; Department of Family and Community Health, University of Pennsylvania School of Nursing, Philadelphia.; Penn Injury Science Center, University of Pennsylvania, Philadelphia.; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia.; Center for Injury Research and Prevention at the Children's Hospital of Philadelphia, Philadelphia., Rix K; Department of Health Promotion and Behavioral Science, University of Texas Health, Houston., Ebert JP; Penn Medicine Nudge Unit, University of Pennsylvania Perelman School of Medicine, Philadelphia.; Department of Emergency Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia., Aryal S; Department of Nursing Faculty, Johns Hopkins School of Nursing, Baltimore, Maryland., Xiong R; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia., Wiebe DJ; University of Michigan, Ann Arbor., Delgado MK; Penn Medicine Nudge Unit, University of Pennsylvania Perelman School of Medicine, Philadelphia.; Department of Emergency Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Publikováno v: JAMA network open [JAMA Netw Open] 2024 Oct 01; Vol. 7 (10), pp. e2439328. Date of Electronic Publication: 2024 Oct 01.

Buprenorphine-Precipitated Withdrawal Among Hospitalized Patients Using Fentanyl.

Autor: Thakrar AP; Division of General Internal Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.; Center for Addiction Medicine and Policy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Christine PJ; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora., Siaw-Asamoah A; Internal Medicine Residency Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Spadaro A; Department of Emergency Medicine, Rutgers New Jersey Medical School, Newark., Faude S; Emergency Medicine Residency, NYU Langone Health, New York, New York., Snider CK; Department of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Delgado MK; Center for Addiction Medicine and Policy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.; Department of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Lowenstein M; Division of General Internal Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.; Center for Addiction Medicine and Policy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Kampman K; Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Perrone J; Center for Addiction Medicine and Policy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.; Department of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Nelson LS; Department of Emergency Medicine, Rutgers New Jersey Medical School, Newark., Kilaru AS; Center for Addiction Medicine and Policy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.; Department of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

Publikováno v: JAMA network open [JAMA Netw Open] 2024 Sep 03; Vol. 7 (9), pp. e2435895. Date of Electronic Publication: 2024 Sep 03.

Firearm violence and associated factors among young adults presenting to emergency departments in three cities: Baseline results from Project SPARK.

Autor: Goldstick JE; Injury Prevention Center, University of Michigan, 2800 Plymouth Road, Suite B10-G080, Ann Arbor, MI, United States of America; Institute for Firearm Injury Prevention, University of Michigan, 1109 Geddes Ave, Ann Arbor, MI, United States of America; Department of Emergency Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, United States of America; Department of Health Behavior and Health Education, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, United States of America. Electronic address: jasoneg@umich.edu., Carter PM; Injury Prevention Center, University of Michigan, 2800 Plymouth Road, Suite B10-G080, Ann Arbor, MI, United States of America; Institute for Firearm Injury Prevention, University of Michigan, 1109 Geddes Ave, Ann Arbor, MI, United States of America; Department of Emergency Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, United States of America; Department of Health Behavior and Health Education, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, United States of America., Whiteside L; School of Medicine, Department of Emergency Medicine, University of Washington, Seattle, WA, United States of America., Delgado MK; Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, United States of America., Stallworth P; Injury Prevention Center, University of Michigan, 2800 Plymouth Road, Suite B10-G080, Ann Arbor, MI, United States of America; Institute for Firearm Injury Prevention, University of Michigan, 1109 Geddes Ave, Ann Arbor, MI, United States of America; Department of Emergency Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, United States of America., Sullivan K; Injury Prevention Center, University of Michigan, 2800 Plymouth Road, Suite B10-G080, Ann Arbor, MI, United States of America; Department of Emergency Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, United States of America., Childs M; Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, United States of America., Taga S; School of Medicine, Department of Emergency Medicine, University of Washington, Seattle, WA, United States of America., Cunningham RM; Injury Prevention Center, University of Michigan, 2800 Plymouth Road, Suite B10-G080, Ann Arbor, MI, United States of America; Institute for Firearm Injury Prevention, University of Michigan, 1109 Geddes Ave, Ann Arbor, MI, United States of America; Department of Emergency Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, United States of America; Department of Health Behavior and Health Education, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, United States of America.

Publikováno v: Preventive medicine [Prev Med] 2024 Sep 02; Vol. 189, pp. 108124. Date of Electronic Publication: 2024 Sep 02.

A randomized trial of behavioral interventions yielding sustained reductions in distracted driving.

Autor: Ebert JP; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Penn Medicine Nudge Unit, University of Pennsylvania, Philadelphia, PA 19104.; Center for Health Incentives and Behavioral Economics, University of Pennsylvania, Philadelphia, PA 19104.; Penn Injury Science Center, Philadelphia, PA 19104., Xiong RA; Penn Medicine Nudge Unit, University of Pennsylvania, Philadelphia, PA 19104.; Center for Health Incentives and Behavioral Economics, University of Pennsylvania, Philadelphia, PA 19104.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Khan N; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Penn Medicine Nudge Unit, University of Pennsylvania, Philadelphia, PA 19104.; Center for Health Incentives and Behavioral Economics, University of Pennsylvania, Philadelphia, PA 19104., Abdel-Rahman D; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Penn Medicine Nudge Unit, University of Pennsylvania, Philadelphia, PA 19104.; Center for Health Incentives and Behavioral Economics, University of Pennsylvania, Philadelphia, PA 19104., Leitner A; Center for Health Incentives and Behavioral Economics, University of Pennsylvania, Philadelphia, PA 19104., Everett WC; Progressive Casualty Insurance Company, Mayfield Village, OH 44143., Gaba KL; Progressive Casualty Insurance Company, Mayfield Village, OH 44143., Fisher WJ; Progressive Casualty Insurance Company, Mayfield Village, OH 44143., McDonald CC; Penn Injury Science Center, Philadelphia, PA 19104.; Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104.; Department of Family Medicine and Community Health, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104., Winston FK; Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104., Rosin RM; Penn Medicine Nudge Unit, University of Pennsylvania, Philadelphia, PA 19104.; Center for Health Incentives and Behavioral Economics, University of Pennsylvania, Philadelphia, PA 19104., Volpp KG; Penn Medicine Nudge Unit, University of Pennsylvania, Philadelphia, PA 19104.; Center for Health Incentives and Behavioral Economics, University of Pennsylvania, Philadelphia, PA 19104.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia, PA 19104., Barnett IJ; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA 19104., Wiebe DJ; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109., Halpern SD; Center for Health Incentives and Behavioral Economics, University of Pennsylvania, Philadelphia, PA 19104.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia, PA 19104.; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA 19104., Delgado MK; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Penn Medicine Nudge Unit, University of Pennsylvania, Philadelphia, PA 19104.; Center for Health Incentives and Behavioral Economics, University of Pennsylvania, Philadelphia, PA 19104.; Penn Injury Science Center, Philadelphia, PA 19104.; Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA 19104.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 06; Vol. 121 (32), pp. e2320603121. Date of Electronic Publication: 2024 Jul 29.