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Bruton's Tyrosine Kinase inhibition by Acalabrutinib does not affect early or advanced atherosclerotic plaque size and morphology in Ldlr-/- mice

Autor: Hemme, Esmeralda, Biskop, Danique, Depuydt, Marie A.C., Smit, Virginia, Delfos, Lucie, Bernabé Kleijn, Mireia N.A., Foks, Amanda C., Kuiper, Johan, Bot, Ilze

Publikováno v: In Vascular Pharmacology June 2023 150

Leukemia inhibitory factor receptor inhibition reduces stenosis grade in LDLR-/- mice

Autor: Hemme, Esmeralda, Depuydt, Marie, Delfos, Lucie, Kuiper, Johan, Bot, Ilze

Publikováno v: In Atherosclerosis August 2024 395 Supplement 1

Blockade of the BLT1-LTB4 axis does not affect mast cell migration towards advanced atherosclerotic lesions in LDLr^−/− mice.

Autor: Depuydt, Marie A. C., Vlaswinkel, Femke D., Hemme, Esmeralda, Delfos, Lucie, Kleijn, Mireia N. A. Bernabé, van Santbrink, Peter J., Foks, Amanda C., Slütter, Bram, Kuiper, Johan, Bot, Ilze

Publikováno v: Scientific Reports; 11/1/2022, Vol. 12 Issue 1, p1-10, 10p

Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells.

Autor: Depuydt MAC; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, the Netherlands., Schaftenaar FH; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, the Netherlands., Prange KHM; Amsterdam University Medical Centers, University of Amsterdam, Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam, the Netherlands., Boltjes A; Central Diagnostic Laboratory, University Medical Center, Utrecht University, Utrecht, the Netherlands., Hemme E; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, the Netherlands., Delfos L; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, the Netherlands., de Mol J; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, the Netherlands., de Jong MJM; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, the Netherlands., Bernabé Kleijn MNA; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, the Netherlands., Peeters JAHM; Department of Surgery, Haaglanden Medisch Centrum Westeinde, The Hague, the Netherlands., Goncalves L; Department of Surgery, Haaglanden Medisch Centrum Westeinde, The Hague, the Netherlands., Wezel A; Department of Surgery, Haaglanden Medisch Centrum Westeinde, The Hague, the Netherlands., Smeets HJ; Department of Surgery, Haaglanden Medisch Centrum Westeinde, The Hague, the Netherlands., de Borst GJ; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, the Netherlands., Foks AC; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, the Netherlands., Pasterkamp G; Central Diagnostic Laboratory, University Medical Center, Utrecht University, Utrecht, the Netherlands., de Winther MPJ; Amsterdam University Medical Centers, University of Amsterdam, Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam, the Netherlands., Kuiper J; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, the Netherlands., Bot I; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, the Netherlands., Slütter B; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, the Netherlands.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2023; Vol. 2 (2), pp. 112-125. Date of Electronic Publication: 2023 Jan 30.