Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice.

Autor: Tsitkanou S; Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States., Morena da Silva F; Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States., Cabrera AR; Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States., Schrems ER; Exercise Muscle Biology Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States., Muhyudin R; Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States., Koopmans PJ; Molecular Muscle Mass Regulation Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States.; Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, Arkansas, United States., Khadgi S; Molecular Muscle Mass Regulation Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States., Lim S; Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States., Delfinis LJ; Muscle Health Research Centre and the School of Kinesiology & Health Sciences, Faculty of Health, York University, Toronto, Ontario, Canada., Washington TA; Exercise Muscle Biology Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States., Murach KA; Molecular Muscle Mass Regulation Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States.; Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, Arkansas, United States., Perry CGR; Muscle Health Research Centre and the School of Kinesiology & Health Sciences, Faculty of Health, York University, Toronto, Ontario, Canada., Greene NP; Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States.

Publikováno v: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Nov 01; Vol. 327 (5), pp. C1308-C1322. Date of Electronic Publication: 2024 Sep 30.

Cardiac Atrophy, Dysfunction, and Metabolic Impairments: A Cancer-Induced Cardiomyopathy Phenotype.

Autor: Ogilvie LM; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Delfinis LJ; School of Kinesiology & Health Science and the Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Coyle-Asbil B; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Vudatha V; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Alshamali R; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Garlisi B; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Pereira M; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Matuszewska K; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Garibotti MC; School of Kinesiology & Health Science and the Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Gandhi S; School of Kinesiology & Health Science and the Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Brunt KR; Department of Pharmacology, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada; IMPART Investigator Team, Saint John, New Brunswick, Canada., Wood GA; Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada., Trevino JG; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Perry CGR; School of Kinesiology & Health Science and the Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Petrik J; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Simpson JA; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada; IMPART Investigator Team, Saint John, New Brunswick, Canada. Electronic address: jeremys@uoguelph.ca.

Publikováno v: The American journal of pathology [Am J Pathol] 2024 Oct; Vol. 194 (10), pp. 1823-1843. Date of Electronic Publication: 2024 Jul 18.

Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia.

Autor: Delfinis LJ; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON, Canada., Ogilvie LM; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Khajehzadehshoushtar S; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON, Canada., Gandhi S; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON, Canada., Garibotti MC; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON, Canada., Thuhan AK; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON, Canada., Matuszewska K; Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada., Pereira M; Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada., Jones RG 3rd; Exercise Science Research Center, Department of Health, Human Performance, and Recreation, University of Arkansas, Fayetteville, AR, USA., Cheng AJ; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON, Canada., Hawke TJ; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Greene NP; Exercise Science Research Center, Department of Health, Human Performance, and Recreation, University of Arkansas, Fayetteville, AR, USA., Murach KA; Exercise Science Research Center, Department of Health, Human Performance, and Recreation, University of Arkansas, Fayetteville, AR, USA., Simpson JA; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Petrik J; Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada., Perry CGR; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 08. Date of Electronic Publication: 2024 Apr 08.

Mitochondrial creatine sensitivity is lost in the D2. mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime.

Autor: Bellissimo CA; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Delfinis LJ; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Hughes MC; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Turnbull PC; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Gandhi S; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada., DiBenedetto SN; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Rahman FA; Faculty of Health, Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada., Tadi P; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Amaral CA; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Dehghani A; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Cobley JN; Redox Biology Group, Centre for Health Sciences, University of the Highlands and Islands, Inverness, United Kingdom., Quadrilatero J; Faculty of Health, Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada., Schlattner U; Laboratory of Fundamental and Applied Bioenergetics, University Grenoble Alpes, Inserm U1055, Grenoble, France and Institut Universiatire de France Paris, France., Perry CGR; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada.

Publikováno v: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2023 May 01; Vol. 324 (5), pp. C1141-C1157. Date of Electronic Publication: 2023 Jan 23.

Correction: Muscle health in a mouse model of Duchenne muscular dystrophy can be partially improved by restoring mitochondrial creatine metabolism.

Autor: Bellissimo CA; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON M3J 1P3, Canada., Delfinis LJ; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON M3J 1P3, Canada., Hughes MC; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON M3J 1P3, Canada., Turnbull PC; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON M3J 1P3, Canada., Gandhi S; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON M3J 1P3, Canada., DiBenedetto SN; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON M3J 1P3, Canada., Rahman F; Faculty of Applied Health Sciences, Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada., Tadi P; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON M3J 1P3, Canada., Amaral C; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON M3J 1P3, Canada., Dehghani A; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON M3J 1P3, Canada., Quadrilatero J; Faculty of Applied Health Sciences, Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada., Schlattner U; Laboratory of Fundamental and Applied Bioenergetics, and SFR Environmental and Systems Biology, University of Grenoble Alpes, Grenoble, France., Perry CGR; School of Kinesiology & Health Science, Muscle Health Research Centre, York University, Toronto, ON M3J 1P3, Canada.

Publikováno v: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2021 Feb; Vol. 46 (2), pp. 190. Date of Electronic Publication: 2020 Dec 23.