Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin.

Autor: Fatemeh Khadir, Christopher R Shaler, Ahmad Oryan, Patrick T Rudak, Delfina M Mazzuca, Tahereh Taheri, Jimmy D Dikeakos, S M Mansour Haeryfar, Sima Rafati

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 8, p e0006701 (2018)

Leishmaniasis is a serious global health problem affecting many people worldwide. While patients with leishmaniasis can be treated with several agents, drug toxicicty and the emergence of resistant strains render available treatments ineffective in t

Externí odkaz: https://doaj.org/article/d7617d3c1b8a423690c9ad2aa72beeec

Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device

Autor: Berardino Pollio, Kelcey Patterson, Joris Braspenning, Alessandra Borchiellini, Alexandra Stolzing, Philip M. Toleikis, Simone Merlin, Alessia Cucci, Martin Zierau, Eugenio Montini, Andrea Calabria, Delfina M. Mazzuca, Chiara Borsotti, Thorsten Bergmann, Adeolu Badi Adewoye, Fabrizio Benedicenti, Cristina Olgasi, Nicholas M. Wragg, Antonia Follenzi, Patrick Bittorf

Publikováno v: Molecular Therapy-Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 551-566 (2021)
Molecular Therapy. Methods & Clinical Development

Hemophilia A (HA) is a rare bleeding disorder caused by deficiency/dysfunction of the FVIII protein. As current therapies based on frequent FVIII infusions are not a definitive cure, long-term expression of FVIII in endothelial cells through lentivir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ff8cd4584a8b2d9e58d1ea9112e85b

Abstracts

Autor: Thorsten Bergmann, Simone Merlin, Cristina Olgasi, Delfina M. Mazzuca, Alexandra Stolzing, Philip Toleikidis, Patrick Bittorf, Joris Braspenning, Martin Zierau, Antonia Follenzi

Publikováno v: Haemophilia. 24:3-196

HemAcure: Application of combined gene and cell therapy within an implantable therapeutic device for the treatment of severe haemophilia A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::748675372be8f246572c59fdd59c3981
https://doi.org/10.1111/hae.13478

Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology

Autor: Kyoungok Kim, John K. McCormick, Ankur Goswami, Peter A. Szabo, S. M. Mansour Haeryfar, Bhagirath Singh, David A. Hess, Ian Welch, David B. O’Gorman, Delfina M. Mazzuca, Howard A. Young

Publikováno v: Bone and Joint Institute

Toxic shock syndrome (TSS) is caused by staphylococcal and streptococcal superantigens (SAgs) that provoke a swift hyperinflammatory response typified by a cytokine storm. The precipitous decline in the host’s clinical status and the lack of target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7018ea275e63525e091ff1fd8edd6e84
https://doi.org/10.4049/jimmunol.1601366

Diabetes Is Reversed in a Murine Model by Marginal Mass Syngeneic Islet Transplantation Using a Subcutaneous Cell Pouch Device

Autor: Rena Pawlick, A. MacGillivary, Boris Gala-Lopez, Philip M. Toleikis, David J. G. White, A. M. James Shapiro, Delfina M. Mazzuca, Andrew R. Pepper

Publikováno v: Transplantation

Background Islet transplantation is a successful β-cell replacement therapy for selected patients with type 1 diabetes mellitus. Although high rates of early insulin independence are achieved routinely, long-term function wanes over time. Intraporta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc4bcb1638b398460ebb45f6e67ff71
https://doi.org/10.1097/tp.0000000000000864