Zobrazeno 1 - 10
of 687
pro vyhledávání: '"Deleterious mutation"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-25 (2024)
Abstract Numerous plant taxa are threatened by habitat destruction or overexploitation. To overcome these threats, new methods are urgently needed for rescuing threatened and endangered plant species. Here, we review the genetic consequences of threa
Externí odkaz:
https://doaj.org/article/9ea2a711ffed44dda667994a5c8bc6d9
Autor:
Tiziana La Bella, Bérangère Bertin, Ante Mihaljevic, Justine Nozi, Patrice Vidal, Sandrine Imbeaud, Jean-Charles Nault, Jessica Zucman-Rossi, Giuseppe Ronzitti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101327- (2024)
Adeno-associated virus (AAV) is the most widely used vector for in vivo gene transfer. A major limitation of capsid engineering is the incomplete understanding of the consequences of multiple amino acid variations on AAV capsid stability resulting in
Externí odkaz:
https://doaj.org/article/4eb4a64865374c90a1f8bbb3efe3c1b0
Autor:
Deyan Wang, Yiling Li, Mengmeng Li, Wenlu Yang, Xinzhi Ma, Lei Zhang, Yubo Wang, Yanlin Feng, Yuanyuan Zhang, Ran Zhou, Brian J. Sanderson, Ken Keefover-Ring, Tongming Yin, Lawrence B. Smart, Stephen P. DiFazio, Jianquan Liu, Matthew Olson, Tao Ma
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-23 (2022)
Abstract Background Salicaceae species have diverse sex determination systems and frequent sex chromosome turnovers. However, compared with poplars, the diversity of sex determination in willows is poorly understood, and little is known about the evo
Externí odkaz:
https://doaj.org/article/3e5f193962d14873abf34d41ae39a821
Autor:
Md. Aminul Islam, Shatila Shahi, Abdullah Al Marzan, Mohammad Ruhul Amin, Mohammad Nayeem Hasan, M. Nazmul Hoque, Ajit Ghosh, Abanti Barua, Abbas Khan, Kuldeep Dhama, Chiranjib Chakraborty, Prosun Bhattacharya, Dong-Qing Wei
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has had a disastrous effect worldwide during the previous three years due to widespread infections with SARS-CoV-2 and its emerging variations. More than 674 million confirmed c
Externí odkaz:
https://doaj.org/article/0236648d1b014f6abd15e6e0b70be2af
Publikováno v:
Frontiers in Plant Science, Vol 13 (2023)
IntroductionCassava (Manihot esculenta) is an annual root crop which provides the major source of calories for over half a billion people around the world. Since its domestication ~10,000 years ago, cassava has been largely clonally propagated throug
Externí odkaz:
https://doaj.org/article/e7f51f800cb7454fa31bef45ca3c0b2d
Publikováno v:
Evolution Letters, Vol 5, Iss 3, Pp 187-195 (2021)
Abstract Runs of homozygosity (ROH) are pervasive in diploid genomes and expose the effects of deleterious recessive mutations, but how exactly these regions contribute to variation in fitness remains unclear. Here, we combined empirical analyses and
Externí odkaz:
https://doaj.org/article/6ee788b65caa4e6593b99f335f5ae232
Autor:
Ming-Shan Wang, Jin-Jin Zhang, Xing Guo, Ming Li, Rachel Meyer, Hidayat Ashari, Zhu-Qing Zheng, Sheng Wang, Min-Sheng Peng, Yu Jiang, Mukesh Thakur, Chatmongkon Suwannapoom, Ali Esmailizadeh, Nalini Yasoda Hirimuthugoda, Moch Syamsul Arifin Zein, Szilvia Kusza, Hamed Kharrati-Koopaee, Lin Zeng, Yun-Mei Wang, Ting-Ting Yin, Min-Min Yang, Ming-Li Li, Xue-Mei Lu, Emiliano Lasagna, Simone Ceccobelli, Humpita Gamaralalage Thilini Nisanka Gunwardana, Thilina Madusanka Senasig, Shao-Hong Feng, Hao Zhang, Abul Kashem Fazlul Haque Bhuiyan, Muhammad Sajjad Khan, Gamamada Liyanage Lalanie Pradeepa Silva, Le Thi Thuy, Okeyo A. Mwai, Mohamed Nawaz Mohamed Ibrahim, Guojie Zhang, Kai-Xing Qu, Olivier Hanotte, Beth Shapiro, Mirte Bosse, Dong-Dong Wu, Jian-Lin Han, Ya-Ping Zhang
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Background Species domestication is generally characterized by the exploitation of high-impact mutations through processes that involve complex shifting demographics of domesticated species. These include not only inbreeding and artificial s
Externí odkaz:
https://doaj.org/article/9b743bf56d994e4c99de696bfaefedb8
Autor:
Xiao-Lin Chu, Quan-Guo Zhang
Publikováno v:
BMC Ecology and Evolution, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Mutation accumulation (MA) has profound ecological and evolutionary consequences. One example is that accumulation of conditionally neutral mutations leads to fitness trade-offs among heterogenous habitats which cause population d
Externí odkaz:
https://doaj.org/article/3c97cda921b64af7bd1492909fdc2ee8
Autor:
Joel Roca-Martinez, Tamas Lazar, Jose Gavalda-Garcia, David Bickel, Rita Pancsa, Bhawna Dixit, Konstantina Tzavella, Pathmanaban Ramasamy, Maite Sanchez-Fornaris, Isel Grau, Wim F. Vranken
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Traditionally, our understanding of how proteins operate and how evolution shapes them is based on two main data sources: the overall protein fold and the protein amino acid sequence. However, a significant part of the proteome shows highly dynamic a
Externí odkaz:
https://doaj.org/article/cb1cd7e3a07a4ee9b141fef663760725
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 5, Pp 1541-1551 (2020)
Theoretical work predicts that sexual selection can enhance natural selection, increasing the rate of adaptation to new environments and helping purge harmful mutations. While some experiments support these predictions, remarkably little work has add
Externí odkaz:
https://doaj.org/article/3af2f0ed12fb455c8d16a5334f39214e