Distinct SIV-specific CD8 ⁺ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence.

Autor: Strongin Z; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Raymond Marchand L; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Deleage C; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA., Pampena MB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for AIDS Research and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cardenas MA; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Beusch CM; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Hoang TN; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Urban EA; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA., Gourves M; Institut Pasteur, Université Paris Cité, Viral Reservoirs and Immune Control Unit, Paris, France.; Institut Pasteur, Université Paris Cité, HIV Inflammation and Persistence Unit, Paris, France., Nguyen K; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Tharp GK; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Lapp S; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Rahmberg AR; Barrier Immunity Section, Laboratory of Viral Diseases, NIAIDNIH, Bethesda, MD, USA., Harper J; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Del Rio Estrada PM; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Gonzalez-Navarro M; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Torres-Ruiz F; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Luna-Villalobos YA; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Avila-Rios S; Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico., Reyes-Teran G; Comision Coordinadora de los Institutos Nacionales de Salud y Hospitales de Alta Especialidad, Mexico City, Mexico., Sekaly R; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Silvestri G; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA., Kulpa DA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Saez-Cirion A; Institut Pasteur, Université Paris Cité, Viral Reservoirs and Immune Control Unit, Paris, France.; Institut Pasteur, Université Paris Cité, HIV Inflammation and Persistence Unit, Paris, France., Brenchley JM; Barrier Immunity Section, Laboratory of Viral Diseases, NIAIDNIH, Bethesda, MD, USA., Bosinger SE; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA., Gordon DE; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for AIDS Research and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kissick HT; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Paiardini M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA. mirko.paiardini@emory.edu.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA. mirko.paiardini@emory.edu.; Emory Vaccine Center, Emory University, Atlanta, GA, USA. mirko.paiardini@emory.edu.

Publikováno v: Nature immunology [Nat Immunol] 2024 Jul; Vol. 25 (7), pp. 1245-1256. Date of Electronic Publication: 2024 Jun 17.

Human galectin-9 promotes the expansion of HIV reservoirs in vivo in humanized mice.

Autor: Yuan Z; The Wistar Institute, Philadelphia, PA, USA., Giron LB; The Wistar Institute, Philadelphia, PA, USA., Hart C; The Wistar Institute, Philadelphia, PA, USA., Gyampoh A; The Wistar Institute, Philadelphia, PA, USA., Koshy J; The Wistar Institute, Philadelphia, PA, USA., Hong KY; The Wistar Institute, Philadelphia, PA, USA., Niki T; Department of Immunology and Immunopathology, Kagawa University, Kagawa, Japan., Premeaux TA; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY., Ndhlovu LC; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY., Deleage C; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Montaner LJ; The Wistar Institute, Philadelphia, PA, USA., Abdel-Mohsen M; The Wistar Institute, Philadelphia, PA, USA.

Publikováno v: AIDS (London, England) [AIDS] 2023 Mar 15; Vol. 37 (4), pp. 571-577. Date of Electronic Publication: 2022 Nov 25.

AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques.

Autor: Dashti A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Sukkestad S; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Horner AM; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Neja M; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Siddiqi Z; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Waller C; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Goldy J; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Monroe D; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Lin A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Schoof N; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Singh V; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Mavigner M; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory University, Atlanta, GA, USA., Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Deleage C; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Tuyishime M; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Falcinelli SD; UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., King HAD; Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Ke R; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, USA., Mason RD; Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Archin NM; UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Dunham RM; UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; HIV Drug Discovery, ViiV Healthcare, Research Traingle Park, NC, USA., Safrit JT; ImmunityBio, Inc., Culver City, CA, USA., Jean S; Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Perelson AS; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, USA., Margolis DM; UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ferrari G; Department of Surgery, Duke University Medical Center, Durham, NC, USA.; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA., Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Silvestri G; Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Chahroudi A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. ann.m.chahroudi@emory.edu.; Emory National Primate Research Center, Emory University, Atlanta, GA, USA. ann.m.chahroudi@emory.edu.; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory University, Atlanta, GA, USA. ann.m.chahroudi@emory.edu.

Publikováno v: Nature medicine [Nat Med] 2023 Oct; Vol. 29 (10), pp. 2535-2546. Date of Electronic Publication: 2023 Oct 02.

Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary.

Autor: Sanders-Beer BE; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Archin NM; Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Busch MP; Vitalant Research Institute, University of California, San Francisco, California, USA., Deleage C; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research (FNLCR), Frederick, Maryland, USA., O'Doherty U; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Hughes SH; HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, Maryland, USA., Jerome KR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, and Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA., Jones RB; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, USA., Karn J; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA., Kearney MF; HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, Maryland, USA., Keele BF; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research (FNLCR), Frederick, Maryland, USA., Kulpa DA; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Laird GM; Accelevir Diagnostics, Baltimore, Maryland, USA., Li JZ; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Lichterfeld MD; Brigham and Women's Hospital and Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA., Persaud D; Department of Pediatric Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Yukl SA; Department of Medicine, University of California San Francisco (UCSF) and San Francisco VA Medical Center, San Francisco, California, USA., Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Mellors JW; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Publikováno v: AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2023 Jun 19. Date of Electronic Publication: 2023 Jun 19.

Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques.

Autor: Byrnes SJ; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia., Busman-Sahay K; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America.; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America., Angelovich TA; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.; Life Science, Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia., Younger S; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America., Taylor-Brill S; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America., Nekorchuk M; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America., Bondoc S; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America., Dannay R; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America., Terry M; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America., Cochrane CR; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia., Jenkins TA; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia., Roche M; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.; Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia., Deleage C; AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Bosinger SE; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Paiardini M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Brew BJ; Peter Duncan Neurosciences Unit, Departments of Neurology and Immunology St Vincent's Hospital, University of New South Wales and University of Notre Dame, Sydney, New South Wales, Australia., Estes JD; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America.; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America., Churchill MJ; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.; Life Science, Burnet Institute, Melbourne, Australia.; Departments of Microbiology and Medicine, Monash University, Clayton, Australia.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 Mar 29; Vol. 19 (3), pp. e1011290. Date of Electronic Publication: 2023 Mar 29 (Print Publication: 2023).