Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Delbert G, Gillespie"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract The metabolic syndrome is characterized by obesity, insulin resistance, dyslipidemia and hypertension and predisposes to cardiorenal injury. Here, we tested our hypothesis that 8-aminoguanine, an endogenous purine, exerts beneficial effects
Externí odkaz:
https://doaj.org/article/c7c5c75c4d9e45b6be0f4f7075d09051
Publikováno v:
Hypertension. 80:981-994
Background: The endogenous purine 8-aminoguanine induces diuresis/natriuresis/glucosuria by inhibiting PNPase (purine nucleoside phosphorylase); however, mechanistic details are unknown. Methods: Here, we further explored in rats 8-aminoguanine’s e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80690c9b158a75341c331003381bfd59
https://doi.org/10.1161/hypertensionaha.122.20760
https://doi.org/10.1161/hypertensionaha.122.20760
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 6 (2021)
Background The long‐term effects of dipeptidyl peptidase 4 (DPP4) inhibitors on blood pressure and cardiovascular and renal health remain controversial. Herein, we investigated the extended (>182 days) effects of DPP4 inhibition in a model of spont
Externí odkaz:
https://doaj.org/article/4dcdb579b11440499c9e74de936ed779
Autor:
Juliana Hofstatter Azambuja, Theresa L. Whiteside, Aparna Rao, Delbert G. Gillespie, Edwin K. Jackson, Nils Ludwig
Publikováno v:
Purinergic Signal
Exosomes, small-sized extracellular vesicles, carry components of the purinergic pathway. The production by cells of exosomes carrying this pathway remains poorly understood. Here, we asked whether type 1, 2A, or 2B adenosine receptors (A(1)Rs, A(2A)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5674cb2f80c3f143e77906333ea096c4
https://doi.org/10.1007/s11302-020-09700-7
https://doi.org/10.1007/s11302-020-09700-7
Autor:
Saigopalakrishna S. Yerneni, Nils Ludwig, Juliana Hofstatter Azambuja, Edwin K. Jackson, Delbert G. Gillespie, Elizabeth V. Menshikova, Theresa L. Whiteside
Publikováno v:
Angiogenesis. 23:599-610
One hallmark of tumor-derived exosomes (TEX) is the promotion of cancer progression by stimulating angiogenesis. This study was performed to evaluate the role of adenosine receptors in TEX-induced angiogenesis. TEX produced by UMSCC47 head and neck c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b298312c0770999966144336ca0d7d7
https://doi.org/10.1007/s10456-020-09728-8
https://doi.org/10.1007/s10456-020-09728-8
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 373:135-148
By reducing their metabolism, dipeptidyl peptidase 4 inhibition (DPP4I) enhances the effects of numerous peptides including neuropeptide Y1-36 (NPY1-36), peptide YY1-36 (PYY1-36), and SDF-1α Studies show that separately NPY1-36, PYY1-36 and SDF-1α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a978ec36f070c64259dfeb3e611a220d
https://doi.org/10.1124/jpet.119.263467
https://doi.org/10.1124/jpet.119.263467
Autor:
Ruth Stiller, Zaichuan Mi, J. Fingerle, Raghvendra K. Dubey, Marinella Rosselli, Bruno Imthurn, Brigitte Leeners, Delbert G. Gillespie, Isabella Baruscotti, Edwin K. Jackson
Publikováno v:
Hypertension. 75:109-118
c-Kit+ progenitor smooth muscle cells (P-SMCs) can develop into SMCs that contribute to injury-induced neointimal thickening. Here, we investigated whether adenosine reduces P-SMC migration and proliferation and whether this contributes to adenosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7aef39203dee80b33cb23265118a8db
https://doi.org/10.1161/hypertensionaha.119.13698
https://doi.org/10.1161/hypertensionaha.119.13698
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The long‐term effects of dipeptidyl peptidase 4 (DPP4) inhibitors on blood pressure and cardiovascular and renal health remain controversial. Herein, we investigated the extended (>182 days) effects of DPP4 inhibition in a model of spont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b729fdb23f6294aea6d9c7409152036
https://doi.org/10.1161/jaha.120.020088
https://doi.org/10.1161/jaha.120.020088
Autor:
Edwin K, Jackson, Elizabeth V, Menshikova, Vladimir B, Ritov, Delbert G, Gillespie, Zaichuan, Mi
Publikováno v:
Biochem Pharmacol
BACKGROUND. 8-Aminoguanine exerts natriuretic and antihypertensive activity. Whether and how “free” 8-aminoguanine exists in vivo is unclear. Because 8-nitroguanosine is naturally occurring, we tested the hypothesis that 8-aminoguanine can arise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cf8eca35c8791c5ecd6dc00cf22096
https://doi.org/10.1016/j.bcp.2022.115076
https://doi.org/10.1016/j.bcp.2022.115076
Autor:
Kyle Holleran, Rhonda M. Brand, Kaleab Z. Abebe, Diane M. Comer, Ian McGowan, Delbert G. Gillespie, John W. Mellors, Bernard J.C. Macatangay, Joshua C. Cyktor, Cynthia Klamar-Blain, Ashley Zyhowski, Sharon A. Riddler, Edwin K. Jackson, Christina Mallarino-Haeger
Publikováno v:
J Acquir Immune Defic Syndr
Background We had previously conducted a double-blind, randomized placebo-controlled, partial cross-over trial showing that 12 weeks of dipyridamole decreased CD8 T-cell activation among treated HIV(+) individuals by increasing extracellular adenosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1a5678e250cecbbebe91c156ecabbe
https://pubmed.ncbi.nlm.nih.gov/33177477
https://pubmed.ncbi.nlm.nih.gov/33177477