Clinical variability and onset age modifiers in an extended Belgian GRN founder family

Autor: Goeman, Johan, Nuytten, Dirk, Vandenbulcke, Mathieu, Michotte, Alex, Salmon, Eric, Deryck, Olivier, Bergmans, Bruno, Willems, Christiana, Delbeck, Jean, Wauters, Eline, Van Mossevelde, Sara, Sleegers, Kristel, van der Zee, Julie, Engelborghs, Sebastiaan, Sieben, Anne, Vandenberghe, Rik, Philtjens, Stéphanie, Van den Broeck, Marleen, Peeters, Karin, Cuijt, Ivy, De Coster, Wouter, Van Langenhove, Tim, Santens, Patrick, Ivanoiu, Adrian, Cras, Patrick, De Bleecker, Jan L., Versijpt, Jan, Crols, Roeland, De Klippel, Nina, Martin, Jean-Jacques, De Deyn, Peter P., Cruts, Marc, Van Broeckhoven, Christine

Publikováno v: In Neurobiology of Aging July 2018 67:84-94

Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients

Autor: Nuytten, Dirk, Smets, Katrien, Versijpt, Jan, Michotte, Alex, Ivanoiu, Adrian, Deryck, Olivier, Bergmans, Bruno, Delbeck, Jean, Bruyland, Marc, Willems, Christiana, Salmon, Eric, Perrone, Federica, Nguyen, Hung Phuoc, Van Mossevelde, Sara, Moisse, Matthieu, Sieben, Anne, Santens, Patrick, De Bleecker, Jan, Vandenbulcke, Mathieu, Engelborghs, Sebastiaan, Baets, Jonathan, Cras, Patrick, Vandenberghe, Rik, De Jonghe, Peter, De Deyn, Peter P., Martin, Jean-Jacques, Van Damme, Philip, Van Broeckhoven, Christine, van der Zee, Julie

Publikováno v: In Neurobiology of Aging March 2017 51:177-177

TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

Autor: van der Zee J; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Gijselinck I; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Van Mossevelde S; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, Antwerp University Hospital, Edegem, Belgium., Perrone F; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Dillen L; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Heeman B; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Bäumer V; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Engelborghs S; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium., De Bleecker J; Department of Neurology, University Hospital Ghent and University of Ghent, Ghent, Belgium., Baets J; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, Antwerp University Hospital, Edegem, Belgium., Gelpi E; Neurological Tissue Bank of the Biobanc - Hospital Clinic-Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Rojas-García R; Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Clarimón J; Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Lleó A; Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Diehl-Schmid J; Department of Psychiatry and Psychotherapy, Technische Universität München, München, Germany., Alexopoulos P; Department of Psychiatry and Psychotherapy, Technische Universität München, München, Germany., Perneczky R; Department of Psychiatry and Psychotherapy, Technische Universität München, München, Germany.; Neuroepidemiology and Ageing Research Unit, School of Public Health, The Imperial College of Science, Technology and Medicine, London, UK.; West London Cognitive Disorders Treatment and Research Unit, West London Mental Health Trust, London, TW8 8DS, UK., Synofzik M; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and Centre of Neurology, Tübingen, Germany.; German Research Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Just J; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and Centre of Neurology, Tübingen, Germany.; German Research Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Schöls L; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and Centre of Neurology, Tübingen, Germany.; German Research Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Graff C; Department of Neurobiology, Care Sciences and Society (NVS), KI-Alzheimer Disease Research Center, Karolinska Institutet, Stockholm, Sweden.; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden., Thonberg H; Department of Neurobiology, Care Sciences and Society (NVS), KI-Alzheimer Disease Research Center, Karolinska Institutet, Stockholm, Sweden.; Department of Geriatric Medicine, Genetics unit, Karolinska University Hospital, Stockholm, Sweden., Borroni B; Neurology Unit, University of Brescia, Brescia, Italy., Padovani A; Neurology Unit, University of Brescia, Brescia, Italy., Jordanova A; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Biochemistry, Molecular Medicine Center, Medical University-Sofia, Sofia, Bulgaria., Sarafov S; Department of Neurology, Medical University-Sofia, Sofia, Bulgaria., Tournev I; Department of Cognitive Science and Psychology, New Bulgarian University, Sofia, Bulgaria., de Mendonça A; Hospital Santa Maria, Lisbon, Portugal.; Faculty of Medicine and Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal., Miltenberger-Miltényi G; Hospital Santa Maria, Lisbon, Portugal.; Faculty of Medicine and Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal., Simões do Couto F; Hospital Santa Maria, Lisbon, Portugal.; Faculty of Medicine and Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal., Ramirez A; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Jessen F; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Heneka MT; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Clinical Neuroscience Unit, Department of Neurology, University of Bonn, Bonn, Germany., Gómez-Tortosa E; Department of Neurology, Fundación Jiménez Díaz, Madrid, Spain., Danek A; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Cras P; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, Antwerp University Hospital, Edegem, Belgium., Vandenberghe R; Department of Neurosciences, Faculty of Medicine, KU Leuven, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium., De Jonghe P; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, Antwerp University Hospital, Edegem, Belgium., De Deyn PP; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium., Sleegers K; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Cruts M; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Van Broeckhoven C; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Goeman J; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Hospital Network Antwerp, Antwerp., Nuytten D; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Hospital Network Antwerp, Antwerp., Smets K; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Antwerp University Hospital, Edegem., Robberecht W; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University Hospitals Leuven Gasthuisberg, Leuven., Damme PV; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University Hospitals Leuven Gasthuisberg, Leuven., Bleecker J; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University Hospital Ghent, Ghent., Santens P; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University Hospital Ghent, Ghent., Dermaut B; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University Hospital Ghent, Ghent., Versijpt J; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University Hospital Brussels, Brussels., Michotte A; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University Hospital Brussels, Brussels., Ivanoiu A; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Saint-Luc University Hospital, Brussels., Deryck O; Center for Molecular Neurology, VIB, Antwerp, Belgium.; General Hospital Sint-Jan Brugge, Bruges., Bergmans B; Center for Molecular Neurology, VIB, Antwerp, Belgium.; General Hospital Sint-Jan Brugge, Bruges., Delbeck J; Center for Molecular Neurology, VIB, Antwerp, Belgium.; General Hospital Sint-Maria, Halle., Bruyland M; Center for Molecular Neurology, VIB, Antwerp, Belgium.; General Hospital Glorieux Ronse., Willems C; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Jessa Hospital, Hasselt., Salmon E; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University of Liège and Memory Clinic, CHU Liège, Liège., Pastor P; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University Hospital Mútua de Terrassa and Fundació Docència i Recerca Mútua Terrassa, University of Barcelona School of Medicine, Terrassa, Barcelona, Spain.; CIBERNED Instituto de Salud Carlos III, Madrid, Spain., Ortega-Cubero S; Center for Molecular Neurology, VIB, Antwerp, Belgium.; CIBERNED Instituto de Salud Carlos III, Madrid, Spain.; Deparment of Neurology, Complejo Asistencial Universitario de Palencia, Palencia, Spain., Benussi L; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Ghidoni R; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Binetti G; Center for Molecular Neurology, VIB, Antwerp, Belgium.; MAC Memory Center and Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Hernández I; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Boada M; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Ruiz A; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Sorbi S; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy., Nacmias B; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy., Bagnoli S; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy., Sorbi S; Center for Molecular Neurology, VIB, Antwerp, Belgium.; IRCCS Don Carlo Gnocchi Scandicci, Florence, Italy., Sanchez-Valle R; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Hospital Clínic, IDIBAPS, Barcelona, Spain., Llado A; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Hospital Clínic, IDIBAPS, Barcelona, Spain., Santana I; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University of Coimbra, Coimbra, Portugal., Rosário Almeida M; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University of Coimbra, Coimbra, Portugal., Frisoni GB; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Hôpitaux Universitaires de Genève et Université de Genève, Genève, Switzerland and IRCCS Fatebenefratelli, Brescia, Italy., Maetzler W; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Hertie Institute for Clinical Brain Research, Tübingen, Germany., Matej R; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Thomayer Hospital, Prague and Charles University, Prague, Czech Republic., Fraidakis MJ; Center for Molecular Neurology, VIB, Antwerp, Belgium.; NeuroRARE Centre for Rare and Genetic Neurological & Neuromuscular Diseases & Neurogenetics Athens, Greece., Kovacs GG; Center for Molecular Neurology, VIB, Antwerp, Belgium.; Medical University of Vienna, Vienna, Austria., Fabrizi GM; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University of Verona, Verona, Italy., Testi S; Center for Molecular Neurology, VIB, Antwerp, Belgium.; University of Verona, Verona, Italy.

Publikováno v: Human mutation [Hum Mutat] 2017 Mar; Vol. 38 (3), pp. 297-309. Date of Electronic Publication: 2017 Jan 19.