T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.

Autor: Bozkus CC; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Parker Institute of Cancer Immunotherapy, San Francisco, CA, USA., Brown M; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Parker Institute of Cancer Immunotherapy, San Francisco, CA, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Velazquez L; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Thomas M; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wilson EA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., O'Donnell T; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ruchnewitz D; Institute for Biological Physics, University of Cologne, 50937 Cologne, Germany., Geertz D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bykov Y; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kodysh J; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Oguntuyo KY; The Department of Medicine, The Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Roudko V; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hoyos D; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Srivastava KD; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kleiner G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Alshammary H; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Karekar N; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., McClain C; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gopal R; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nie K; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Del Valle D; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Delbeau-Zagelbaum D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rodriguez D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Setal J; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Carroll E; The Department of Medicine, The Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wiesendanger M; The Department of Medicine, The Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gulko PS; The Department of Medicine, The Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Charney A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Merad M; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kim-Schulze S; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wajnberg A; The Department of Medicine, The Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Greenbaum BD; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY, USA., Chowell D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Vabret N; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Luksza M; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bhardwaj N; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Parker Institute of Cancer Immunotherapy, San Francisco, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 24. Date of Electronic Publication: 2024 Oct 24.